Category: 214834-18-1

Chemistry is traditionally divided into organic and inorganic chemistry. HPLC of Formula: C11H20N2O2S. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 214834-18-1

Pyrroloquinoline Derivatives And Their Use As Protein Kinases Inhibitors

The present invention relates to inhibitors of protein kinases of formula I: which can be used in the treatment of various diseases, notably cancer, inflammation or disorders of the central nervous system. It also relates to pharmaceutical compositions containing the compounds according to the invention and their use in therapy.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.HPLC of Formula: C11H20N2O2S, you can also check out more blogs about214834-18-1

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H20361N – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.214834-18-1,tert-Butyl 4-carbamothioylpiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

55 mg (1.5 mmol) of 4-thiocarbamoyl-piperidine-1-tert-butyl carboxylate is added to a suspension of 57 mg (0.15 mmol) of 8-(2-bromo-acetyl)-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate in 3 mL of ethanol. The mixture is stirred at 90 C. for 3 hours then the mixture is cooled to room temperature. Triethylamine (2 mmol) is added, then the solvent is evaporated and the product is purified by chromatography on silica (chloroform/methanol/triethylamine 8/2/1). After drying, 11 mg (17%) of 4-oxo-8-(2-piperidin-4-yl-thiazol-4-yl)-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate is obtained in the form of a beige solid.LCMS (IE, m/z): (M+1) 423.241H-NMR: deltaH ppm 400 MHz, DMSO11.76 (1H, bs, NH), 9.76 (1H, d, CHarom), 8.00 (1H, s, CHarom), 7.95 (1H, dd, CHarom), 7.74 (1H, s, CHarom), 7.44 (1H, d, CHarom), 4.35 (2H, q, CH2), 3.35-3.30 (1H, m, CHpiper), 3.16-3.10 (2H, m, 2¡ÁCHpiper), 2.80-2.72 (2H, m, 2¡ÁCHpiper), 2.13-2.06 (2H, m, 2¡ÁCHpiper), 1.77-1.68 (2H, m, 2¡ÁCHpiper), 1.36 (3H, t, CH3).

214834-18-1, The synthetic route of 214834-18-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Pierre Fabre Medicament; US2009/42876; (2009); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

214834-18-1, tert-Butyl 4-carbamothioylpiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 1: Preparation of E-3-{4-[4-(3,4-ethylendioxphenyl)-thiazol-2-yl]-piperidin-1-yl}-1-(3,4-methylendioxyphenyl)-3-prop-1-ene (Compound I) [Show Image] A. Preparation of intermediate (7) [Show Image] To a solution of tert-butyl 4-(aminocarbonothioyl)piperidine-1-carboxylate (5) (1 eq.) in DMF (5 vol eq.) a solution of bromoketone (6) (1.05 eq.) in DMF (10 vol eq.) is added drop wise at 0C. The mixture is left to stir overnight gradually warming to room temperature. Triethylamine (2.2 eq.) is added portionwise to the resulting solution at room temperature, and then stirred for further 30 minutes. The reaction mixture is poured into water and extracted 3 times with ethyl acetate. The organic layers are combined, washed with waterand brine, dried overnight over MgSO4, and concentrated in vacuo. The desired product is obtained as a pale orange oily residue, collected and dried in a vacuum oven. Yield 68%., 214834-18-1

214834-18-1 tert-Butyl 4-carbamothioylpiperidine-1-carboxylate 2735648, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Oridis Biomed Forschungs- und Entwicklungs GmbH; EP1832585; (2007); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem