With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.204376-55-6,1-Fmoc-4-piperidone,as a common compound, the synthetic route is as follows.
To a dried scintillation vial containing a magnetic stir bar was added piperidinone200 (642 mg, 2.0 mmol), H2N-PEG2-C02t-Bu (560 mg, 2.4 mmol), 4 A molecular sieves (activated powder, 500 mg), and 1,2-dichloroethane (5 mL). The mixture was stirred for 1 h at room temperature. To the reaction mixture was added sodium triacetoxyborohydride (845 mg, 4.0 mmol). The mixture was stirred for 5 days at room temperature. The resulting mixture was diluted with EtOAc. The organic layer was washed with saturated NaHCO3 (1 x 50 mL), and brine (1 x 50 mL), dried over Na2504, filtered, and concentrated under reduced pressure to yield compound 201 as an oil, which was carried forward without further purification.
204376-55-6, The synthetic route of 204376-55-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; R.P. SCHERER TECHNOLOGIES, LLC; RABUKA, David; MCFARLAND, Jesse M.; DRAKE, Penelope M.; BARFIELD, Robyn M.; (195 pag.)WO2017/83306; (2017); A1;,
Piperidine – Wikipedia
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