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The synthesis method comprises the following steps: N – dissolving the aniline in diethyl ether, adding the catalyst 5 – adding the catalyst 3 – under stirring, carrying out reflux reaction under stirring conditions, filtering N – and 3 distilling under reduced pressure N . The synthesis method is simple in preparation process, short in production process, high in raw material conversion rate, low in production cost and high in economic benefit. (by machine translation)

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Piperidine – Wikipedia,
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Herein we describe a mild method for the dual C(sp3)?H bond functionalization of saturated nitrogen-containing heterocycles through a sequential visible-light photocatalyzed dehydrogenation/[2+2] cycloaddition procedure. As a complementary approach to the well-established use of iminium ion and alpha-amino radical intermediates, the elusive cyclic enamine intermediates were effectively generated by photoredox catalysis under mild conditions and efficiently captured by acetylene esters to form a wide array of bicyclic amino acid derivatives, thus enabling the simultaneous functionalization of two vicinal C(sp3)?H bonds.

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Through-bond interaction (TBI) in N-aryl-4-piperidone derivatives in which the carbonyl group is modified to enhance its electron deficiency is found to stabilize the sterically disfavored axial arrangement of the aryl group, an arrangement also found in the corresponding tropanone derivatives, where it may, however, be favored sterically.In the N-arylpiperidone derivatives the relative stability of conformations with axial and equatorial orientation of the phenyl group is markedly influenced by para substitution in the aryl group thus indicating the possibility of long-range stereoelectronic conformational control mediated by through-bond interaction across three ?-bonds.Theoretical predictions regarding the influence of TBI on bond lengths are confirmed in the crystal structures of the compounds studied, while strong TBI is also found to result in significant pyramidalization at C4.

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A stereospecific synthesis of dendrobates (±)-alkaloid 241D is described. Key steps in this approach involved the stepwise electrochemical synthesis of C-4 substituted alpha-aminonitriles and their alkylation with iodomethane and 1-bromononane, respectively. The N-aryl group was removed in the last step through a Birch dearomatization followed by the hydrolysis of the intermediate dienamines.

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Piperidine – Wikipedia,
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Compounds useful as reversible inhibitors of cysteine proteases

Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (I), (II), (Ia) and (Ib) further defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes for making such novel compounds. 1

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FUSED THIOPHENE DERIVATIVES AND THEIR USES

The present invention relates to a new class of fused thiophene derivatives and their uses for treating diseases such as infection, cancer, metabolic diseases, cardiovascular diseases, iron storage disorders and inflammatory disorders.

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EXCITED-STATE DIPOLE MOMENT AND SOLVATOCHROMISM OF HIGHLY FLUORESCENT ROD-SHAPED BICHROMOPHORIC MOLECULES.

Efficient photoinduced charge separation can occur in molecules containing electron donor (D) and acceptor (A) groups separated by an elongated paraffinic spacer. For two molecules of this type the dipole moment of the excited state thus achieved (D** plus -A** minus ) is shown to be as high as 25 plus or minus 2 D via nanosecond time-resolved microwave conductivity measurements. Despite the lack of either direct D/A contact or coupling via a pi -electron system the dipolar excited states are found to emit charge-transfer-type fluorescence with a quantum yield exceeding 50% in some solvents. The enormous solvatochromism of this fluorescence makes these molecules attractive as fluorescent polarity probes.

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Piperidine – Wikipedia,
Piperidine | C5H10483N – PubChem