Category: 190906-92-4

190906-92-4, tert-Butyl 2-methyl-4-oxopiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of 1-boc-2-methylpiperidin-4-one (0.55 g, 2.6 mmol, 1 eq) in dry DCM(7.5 mL) was cooled at 0C and DAST (0.68 mL, 5.2 mmol, 2 eq) was added dropwise.The reaction was stirred overnight at 10C, then diluted with DCM (10 mL), washed withNaHCO3 sat. solution (lOmL), 5% citric acid solution in water (10 mL) and finally withbrine (10 mL). The organic layer was dried over anh. Na2504, filtered and evaporated.The residue was purified by flash chromatography on silica gel (eluent 10/90 EtOAc/petroleum ether) affording 0.53 g of pure 1-N-boc-4,4-difluoromethylpiperidine as white solid., 190906-92-4

190906-92-4 tert-Butyl 2-methyl-4-oxopiperidine-1-carboxylate 12992764, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; AXXAM S.P.A.; PEVARELLO, Paolo; LOHMER, Stefan; LIBERATI, Chiara; SENECI, Pierfausto; PESENTI, Cristina; PRANDI, Adolfo; WO2015/118019; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.190906-92-4,tert-Butyl 2-methyl-4-oxopiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

Resolve racemic 2-methyl-4-oxo-piperidine-1-carboxylic acid tert-butyl ester (15.0 g) using a CHIRALPAK ADTM (4.6 x 250nm) column, eluting with absolute ethanol at a flow rate of 1.0 ML/MINUTE (UV=220nm) to obtain isomer 1 (5.28 g, 35%) and isomer 2 (5.01 g, 33%). 1H NMR (CDCl3) : 4.7 (m, 1H), 4.2 (m, 1H), 3.3 (m, 1H), 2.7 (m, 1H), 2.5 (m, 1H), 2.3 (m, 1H), 2.2 (m, 1H), 1.5 (s, 9H), 1.2 (d, 3H); identical for both isomers.

190906-92-4, 190906-92-4 tert-Butyl 2-methyl-4-oxopiperidine-1-carboxylate 12992764, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; ELI LILLY AND COMPANY; WO2004/94380; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem