Category: 189442-78-2

New learning discoveries about 189442-78-2

189442-78-2, The synthetic route of 189442-78-2 has been constantly updated, and we look forward to future research findings.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.189442-78-2,1-Boc-N-methoxy-N-methylpiperidine-3-carboxamide,as a common compound, the synthetic route is as follows.

A solution of tert-butyl 3 -(methoxy(methyl)carbamoyl)piperidine- I -carboxylate (1.0 g, 3.7mmol) in 5 ml of DCM was charged with 5 ml of TFA and stirred at room temperature for one hour. The mixture was then concentrated in vacuo and azeotroped twice with toluene. Theresidue was then diluted with 5 ml of THF and 5 ml of methanol and charged withpropionaldehyde (450 mg, 7.7 mmol) and Sodium Triacetoxyborohydride (1.6 g, 7.7 mniol).The mixture was then stirred at room temperature for one hour and concentrated in vacuo. Themixture was then diluted with ethyl acetate and water. The aqueous was discarded and the organic layer was washed once with water, dried over Na2SO4, filtered, and concentrated in vacuo. The residue was then purified by silica-gel chromatography (1 -10% MeOH in DCM) to afford the the title compound (600 mg, 73% yield).

189442-78-2, The synthetic route of 189442-78-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.; ALBRECHT, Brian, K.; COTE, Alexandre; GEHLING, Victor; HSIAO-WEI TSUI, Vickie; KIEFER, James, Richard, Jr.; LIANG, Jun; MAGNUSON, Steven; NASVESCHUK, Christopher, G.; PASTOR, Richard; ROMERO, F. Anthony; TAYLOR, Alexander, M.; ZHANG, Birong; (287 pag.)WO2016/112284; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

Analyzing the synthesis route of 189442-78-2

189442-78-2 1-Boc-N-methoxy-N-methylpiperidine-3-carboxamide 22248320, apiperidines compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.189442-78-2,1-Boc-N-methoxy-N-methylpiperidine-3-carboxamide,as a common compound, the synthetic route is as follows.

Step 2: To a solution of compound B (4.7 g, 17.2 mMol) in 70 ml of THF at 0 C. (under N2) was added a 3.0 M (11.5 ml, 34.5 mMol) solution of Methyl Magnesium Bromide in THF. After the addition was complete, the cooling bath was removed and the resulting mixture was allowed to rise to room temperature where it was allowed to stir overnight. The resulting mixture was quenched with a saturated aqueous KHSO4 solution and diluted with EtOAc. The organic phase was washed with brine, dried over MgSO4, filtered and evaporated to dryness. The crude residue was passed through a plug of silica gel and eluted with 5-20% EtOAc/Hexane. Yield: 2.37 g, approximately 60%. H NMR (500 MHz, CDCl3) 4.10 (d, J=12.0 Hz, H), 3.92 (s, H), 2.94 (dd, J=10.3, 13.3 Hz, H), 2.82-2.77 (m, H), 2.52-2.48 (m, H), 2.18 (s, 3H), 1.98 (dd, J=3.6, 12.9 Hz, H), 1.73-1.69 (m, H), 1.56-1.44 (m, 11H).

189442-78-2 1-Boc-N-methoxy-N-methylpiperidine-3-carboxamide 22248320, apiperidines compound, is more and more widely used in various.

Reference£º
Patent; Ledeboer, Mark; Pierce, Albert; Bemis, Guy; Farmer, Luc; Wang, Tiansheng; Messersmith, David; Duffy, John; Salituro, Francesco; Wang, Jian; US2006/183761; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

Analyzing the synthesis route of 189442-78-2

189442-78-2 1-Boc-N-methoxy-N-methylpiperidine-3-carboxamide 22248320, apiperidines compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.189442-78-2,1-Boc-N-methoxy-N-methylpiperidine-3-carboxamide,as a common compound, the synthetic route is as follows.

Step 2: To a solution of compound B (4.7 g, 17.2 mMol) in 70 ml of THF at 0 C. (under N2) was added a 3.0 M (11.5 ml, 34.5 mMol) solution of Methyl Magnesium Bromide in THF. After the addition was complete, the cooling bath was removed and the resulting mixture was allowed to rise to room temperature where it was allowed to stir overnight. The resulting mixture was quenched with a saturated aqueous KHSO4 solution and diluted with EtOAc. The organic phase was washed with brine, dried over MgSO4, filtered and evaporated to dryness. The crude residue was passed through a plug of silica gel and eluted with 5-20% EtOAc/Hexane. Yield: 2.37 g, approximately 60%. H NMR (500 MHz, CDCl3) 4.10 (d, J=12.0 Hz, H), 3.92 (s, H), 2.94 (dd, J=10.3, 13.3 Hz, H), 2.82-2.77 (m, H), 2.52-2.48 (m, H), 2.18 (s, 3H), 1.98 (dd, J=3.6, 12.9 Hz, H), 1.73-1.69 (m, H), 1.56-1.44 (m, 11H).

189442-78-2 1-Boc-N-methoxy-N-methylpiperidine-3-carboxamide 22248320, apiperidines compound, is more and more widely used in various.

Reference£º
Patent; Ledeboer, Mark; Pierce, Albert; Bemis, Guy; Farmer, Luc; Wang, Tiansheng; Messersmith, David; Duffy, John; Salituro, Francesco; Wang, Jian; US2006/183761; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem