189321-63-9, 1-Boc-4-Methylpiperidine-4-carboxylic acid is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Method W Preparation of 1-(4-methylpiperidin-4-yl)-5-(methylsulfonyl)-1H-benzimidazole Step 1: Preparation of tert-butyl 4 amino-4-methylpiperidine-1-carboxylate; To a solution of 1-(tert-butoxycarbonyl)-4-methylpiperidine-4-carboxylic acid (3.5 g) in anhydrous toluene (50 ml) was added diphenylphosphorylazide (3.72 ml) followed by triethylamine (2.4 ml) and the resulting mixture was heated to 100 C. for 90 minutes. The mixture was cooled, quenched with saturated sodium bicarbonate (20 ml). The organic layer was separated, dried and evaporated to dryness. The crude product was dissolved in tetrahydrofuran (50 ml) to which was added potassium trimethylsilanolate (4.1 g). The resulting mixture was stirred at room temperature for 48 hours. The reaction mixture was filtered, evaporated to 10 ml and poured directly onto an SCX-Silica bond elut. The product was eluted with 0.7M ammonia solution in methanol to give the title compound as an oil (2.83 g); M+H 159 (-tert-butyl); NMR (CDCl3) 1.2(s, 3H), 1.4(m, 4H) 1.5 (s, 9H), 3.4(m, 4H):
189321-63-9, As the paragraph descriping shows that 189321-63-9 is playing an increasingly important role.
Reference：
Patent; Faull, Alan; Tucker, Howard; US2007/167442; (2007); A1;,
Piperidine – Wikipedia
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