Category: 184637-48-7

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, COA of Formula: C10H20N2O2, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 184637-48-7, Name is tert-Butyl 3-aminopiperidine-1-carboxylate, molecular formula is C10H20N2O2. In a Patent, authors is ，once mentioned of 184637-48-7

This invention relates to new benzazepine dicarboxamide compounds of the formula (I) wherein R1 to R4 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are TLR agonists and may therefore be useful as medicaments for the treatment of diseases such as cancer, autoimmune diseases, inflammation, sepsis, allergy, asthma, graft rejection, graft-versus-host disease, immunodeficiencies, and infectious diseases.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 184637-48-7, help many people in the next few years.COA of Formula: C10H20N2O2

Reference：
Piperidine – Wikipedia,
Piperidine | C5H13519N – PubChem

 

Reference of 184637-48-7, In heterogeneous catalysis, the catalyst is in a different phase from the reactants. At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 184637-48-7, name is tert-Butyl 3-aminopiperidine-1-carboxylate. In an article，Which mentioned a new discovery about 184637-48-7

Targeting indoleamine 2,3-dioxygenase 1 (IDO1) has been identified as an attractive approach for the development of cancer immunotherapy. In this study, a series of phosphonamidate ester containing compounds were designed, synthesized and evaluated for their inhibitory activities against IDO1. Among them, compounds 16, 17, and 26 with good IDO1 inhibitory (HeLa IDO1 IC50 = 10?21 nM, hIDO1 IC50 = 78?121 nM) activities were selected for further investigation and showed good physicochemical properties. Furthermore, based on comparable PK profile and excellent IDO2/TDO inhibitory potency, representative compound 16 was selected for further bio-evaluation and characterized with good efficacy in suppressing lung metastasis (77% inhibition rate) of Lewis cells in vivo. Thus, compound 16 could be a potential and efficacious agent for further evaluation.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.184637-48-7. In my other articles, you can also check out more blogs about 184637-48-7

Reference：
Piperidine – Wikipedia,
Piperidine | C5H13578N – PubChem

 

Application of 184637-48-7, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 184637-48-7, Name is tert-Butyl 3-aminopiperidine-1-carboxylate, molecular formula is C10H20N2O2. In a Patent£¬once mentioned of 184637-48-7

1,5-NAPHTHYRIDINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME

The present invention directs a compound represented by formula (I)

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Application of 184637-48-7, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 184637-48-7, in my other articles.

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H13559N – PubChem

 

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 184637-48-7, name is tert-Butyl 3-aminopiperidine-1-carboxylate, introducing its new discovery. COA of Formula: C10H20N2O2

NOVEL M3 MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS

Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 184637-48-7 is helpful to your research. COA of Formula: C10H20N2O2

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Piperidine – Wikipedia,
Piperidine | C5H13590N – PubChem

 

Synthetic Route of 184637-48-7, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 184637-48-7, Name is tert-Butyl 3-aminopiperidine-1-carboxylate, molecular formula is C10H20N2O2. In a Patent£¬once mentioned of 184637-48-7

Uracil derivatives, its preparation method and application thereof (by machine translation)

The invention relates to a compound of general formula I indicated by the uracil derivatives, their pharmaceutically acceptable salt, a solvate of said derivatives and the pharmaceutically acceptable salt of solvate; the invention also relates to a preparation method of the uracil derivative and its as therapeutic agents in particular as dipeptidyl peptidase – IV (DPP – IV) inhibitors Type I. (by machine translation)

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Synthetic Route of 184637-48-7, you can also check out more blogs about184637-48-7

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Piperidine – Wikipedia,
Piperidine | C5H13568N – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184637-48-7,tert-Butyl 3-aminopiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

Example 6Step 1tert-Butyl 1-(7-(3,4-dimethoxyphenylamino)thiazolo[5,4-d]pyrimidin-5-yl)piperidin-3-ylcarbamate Procedure:To a stirred solution of tert-butyl 1-(7-(3,4-dimethoxyphenylamino)thiazolo[5,4-d]pyrimidin-5-yl)piperidin-3-ylcarbamate (140 mg, 0.433 mmol), tert-butyl piperidin-3-ylcarbamate (130 mg, 0.649 mmol), X-Phos (115 mg, 0.24 mmol) and Cs2CO3 (580 mg, 1.78 mmol) in 60 mL of dry dioxane was added Pd2(dba)3 (60 mg, 0.065 mmol) in one portion at room temperature under nitrogen. Then the reaction mixture was degassed with nitrogen for 15 minutes. After that, the mixture was stirred at 95¡ã C. under nitrogen for 24 hours. The solvent was evaporated and the residue was purified by silica gel chromatography (silica gel 200-300 mesh, petroleum ether:ethyl acetate=1:2) to give tert-butyl 1-(7-(3,4-dimethoxyphenylamino)thiazolo[5,4-d]pyrimidin-5-yl)piperidin-3-ylcarbamate (195 mg, 92.8percent) as a solid. LC-MS: 487.1 [M+H]+, tR=1.67 min., 184637-48-7

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Reference£º
Patent; Hermann, Johannes Cornelius; Lowrie, JR., Lee Edwin; Lucas, Matthew C.; Luk, Kin-Chun Thomas; Padilla, Fernando; Wanner, Jutta; Xie, Wenwei; Zhang, Xiaohu; US2012/252777; (2012); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184637-48-7,tert-Butyl 3-aminopiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.,184637-48-7

[00585] To a stuffed solution of 2-[4-(3-fluoro-phenoxy)-phenoxy]-5-iodo-nicotinic acid methyl ester (1.50 g; 2.77 mmol; 1.00 eq.) in 1,4-dioxane (30.00 ml; 20.00 V) were added piperidin-3-yl-carbamic acid tert-butyl ester (0.72 g; 3.33 mmol; 1.20 eq.) and cesium carbonate (1.86 g; 5.55 mmol; 2.00 eq.) at RT under nitrogen atmosphere. The resulting reaction mixture was degassed with nitrogen for 20 mm and then treated with dicyclohexyl-(2?,6?-diisopropoxy-biphenyl-2-yl)-phosphane (0.07 g; 0.14 mmol; 0.05 eq.) andtris(dibenzylideneacetone)dipalladium(0) (0.26 g; 0.28 mmol; 0.10 eq.). The reaction mixture was heated in a sealed tube to 100 C for 16 h. Upon completion of the reaction (monitored by TLC), the reaction mixture was cooled to RT and filtered through Celite. The Celite was washed with EtOAc (50 mL). The filtrate was washed with water (lx 50 mL) and brine (1 x 20 mL), dried over sodium sulphate and concentrated under vacuum. The residue was purified by column chromatograpy over silica gel (60-120 mesh) by using (3:7) EtoAc:Pet ether as an eluent to afford tert-butoxycarbonylamino-6?- [4-(3-fluoro-phenoxy)-phenoxy] -3,4,5 ,6-tetrahydro-2H- [1,3?] bipyridinyl-5?-carboxylic acid methyl ester (1.20 g, 60.3 %) as a yellow solid. HPLC: 74.91 % purity. MS m/z = 538 [M+H]. ?H NMR (400 MHz, DMSO-d6) oe 8.04-8.02 (d, J= 4.3 Hz, 2H), 7.77-7.76 (d, J= 3.1 Hz, 1H), 7.43-7.37 (m, 1H), 7.09-7.06 (m, 4H), 6.97-6.91 (m, 2H), 6.86-6.79 (m, 2H), 3.8 (s, 3H), 3.54-3.48 (m, 3H), 2.74-2.59 (m, 2H), 1.8 1-1.72 (m, 1H), 1.6 (s, 1H),1.4 (s, 9H).

184637-48-7 tert-Butyl 3-aminopiperidine-1-carboxylate 545809, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK PATENT GMBH; QIU, Hui; CALDWELL, Richard D.; NEAGU, Constantin; MOCHALKIN, Igor; LIU-BUJALSKI, Lesley; JONES, Reinaldo; TATE, Devon; JOHNSON, Theresa L.; GARDBERG, Anna; WO2015/61247; (2015); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184637-48-7,tert-Butyl 3-aminopiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.,184637-48-7

[00585] To a stuffed solution of 2-[4-(3-fluoro-phenoxy)-phenoxy]-5-iodo-nicotinic acid methyl ester (1.50 g; 2.77 mmol; 1.00 eq.) in 1,4-dioxane (30.00 ml; 20.00 V) were added piperidin-3-yl-carbamic acid tert-butyl ester (0.72 g; 3.33 mmol; 1.20 eq.) and cesium carbonate (1.86 g; 5.55 mmol; 2.00 eq.) at RT under nitrogen atmosphere. The resulting reaction mixture was degassed with nitrogen for 20 mm and then treated with dicyclohexyl-(2?,6?-diisopropoxy-biphenyl-2-yl)-phosphane (0.07 g; 0.14 mmol; 0.05 eq.) andtris(dibenzylideneacetone)dipalladium(0) (0.26 g; 0.28 mmol; 0.10 eq.). The reaction mixture was heated in a sealed tube to 100 C for 16 h. Upon completion of the reaction (monitored by TLC), the reaction mixture was cooled to RT and filtered through Celite. The Celite was washed with EtOAc (50 mL). The filtrate was washed with water (lx 50 mL) and brine (1 x 20 mL), dried over sodium sulphate and concentrated under vacuum. The residue was purified by column chromatograpy over silica gel (60-120 mesh) by using (3:7) EtoAc:Pet ether as an eluent to afford tert-butoxycarbonylamino-6?- [4-(3-fluoro-phenoxy)-phenoxy] -3,4,5 ,6-tetrahydro-2H- [1,3?] bipyridinyl-5?-carboxylic acid methyl ester (1.20 g, 60.3 %) as a yellow solid. HPLC: 74.91 % purity. MS m/z = 538 [M+H]. ?H NMR (400 MHz, DMSO-d6) oe 8.04-8.02 (d, J= 4.3 Hz, 2H), 7.77-7.76 (d, J= 3.1 Hz, 1H), 7.43-7.37 (m, 1H), 7.09-7.06 (m, 4H), 6.97-6.91 (m, 2H), 6.86-6.79 (m, 2H), 3.8 (s, 3H), 3.54-3.48 (m, 3H), 2.74-2.59 (m, 2H), 1.8 1-1.72 (m, 1H), 1.6 (s, 1H),1.4 (s, 9H).

184637-48-7 tert-Butyl 3-aminopiperidine-1-carboxylate 545809, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK PATENT GMBH; QIU, Hui; CALDWELL, Richard D.; NEAGU, Constantin; MOCHALKIN, Igor; LIU-BUJALSKI, Lesley; JONES, Reinaldo; TATE, Devon; JOHNSON, Theresa L.; GARDBERG, Anna; WO2015/61247; (2015); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

184637-48-7, tert-Butyl 3-aminopiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 6 Intermediate 6.1: 3-tert-Butoxycarbonylamino-1,1-bis-[3-(4-methoxy-phenyl)-propyl]-piperidinium trifluoroacetate Piperidin-3-yl-carbamic acid tert-butyl ester (1 g, 5 mmol) and 1-(3-Bromo-propyl)-4-methoxy-benzene (2.3 ml, 13 mmol), potassium carbonate (1.6 g, 11.6 mmol) and sodium iodide (1.3 g, 8.7 mmol) are dissolved in acetonitril (40 ml) and stirred at reflux for 5 days. The solvent is removed under vacuo and the product purified by preparative HPLC-MS (MeOH/H2O+0.1percent TFA). LC (method F): tR=1.89 min; Mass spectrum (ESI+): m/z=497 [M]+.

184637-48-7, The synthetic route of 184637-48-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; WIEDENMAYER, Dieter; HECKEL, Armin; HAMPRECHT, Dieter; US2015/45326; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.184637-48-7,tert-Butyl 3-aminopiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of 3-((terf-butoxycarbonyl)amino)piperidine (400 mg, 2.0 mmol) in DCM (10 mL) was added triethylamine (0.50 mL, 3.6 mmol) followed by methyl chloroformate (0.20 mL, 2.6 mmol). After stirring overnight, the reaction was concentrated, diluted with EtOAc and washed with 0.5 N HCI, water and brine. The organic layer was dried over sodium sulfate, filtered and concentrated to afford the title compound as a white solid (502 mg, 97percent yield). 1H NMR (400 MHz, CD3SOCD3) delta 1 .27-1 .35 (m, 2 H), 1 .38 (s, 9 H), 1 .62-1 .69 (m, 1 H), 1 .72-1 .80 (m, 1 H), 2.74-2.83 (m, 1 H), 3.20-3.28 (m, 1 H), 3.52-3.58 (m, 1 H), 3.58 (s, 3 H), 3.66-3.74 (m, 1 H), 3.76-3.89 (m, 1 H), 6.85-6.91 (m, 1 H)., 184637-48-7

The synthetic route of 184637-48-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; DEATON, David Norman; GUO, Yu; HANCOCK, Ashley Paul; SCHULTE, Christie; SHEARER, Barry George; SMITH, Emilie Despagnet; STEWART, Eugene L.; THOMSON, Stephen Andrew; (556 pag.)WO2018/69863; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem