Category: 179474-79-4

179474-79-4, Name is 1-(3-Methoxypropyl)piperidin-4-amine, molecular formula is C9H20N2O, Name: 1-(3-Methoxypropyl)piperidin-4-amine, belongs to piperidines compound, is a common compound. In a patnet, author is Moumaneix, Lilian, once mentioned the new application about 179474-79-4.

Investigation of and mechanism proposal for solvothermal reaction between sodium and 1-(2-hydroxyethyl)piperidine as the first step towards nitrogen-doped graphenic foam synthesis

For the purpose of synthetizing 3-dimensional nitrogen-doped graphenic materials, which could be used as oxygen reduction catalysts in membrane fuel cells, a solvothermal-based route was successfully carried out. However, the solvothermal reaction between metallic sodium and 1-(2-hydroxyethyl)piperidine (HEP), with the latter as the source of both carbon and nitrogen, is still little understood. The present work was aimed at investigating the solvothermal process under different conditions of temperature and pressure and with different amounts of sodium. Use ofin situmass spectroscopy during the three-day reaction revealed the early formation of dihydrogen, as well as carbon oxides, methane and ammonia, in addition to fragments of ethylpiperidine alkoxide (EP-ONa). XRD measurements evidenced the formation of sodium-based compounds,e.g.hydride, carbonate, hydroxide, and cyanide. Interestingly, Raman spectroscopy revealed the significant presence of large aromatic molecules as well as an sp(2)carbon network, an early precursor of graphene. Analysis of the overpressures and reaction yields suggests that the primary compound from the reaction of HEP with sodium is a large sp(2)carbon-based network entrapping numerous sodium-based molecules as well as a volatile liquid phase. The suggested reaction mechanism provides information to better tailor the solvothermal products, whose pyrolysis at 850 degrees C led to very high specific area nitrogen-doped carbon materials.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 179474-79-4 help many people in the next few years. Name: 1-(3-Methoxypropyl)piperidin-4-amine.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry is an experimental science, Product Details of 179474-79-4, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 179474-79-4, Name is 1-(3-Methoxypropyl)piperidin-4-amine, molecular formula is C9H20N2O, belongs to piperidines compound. In a document, author is Wang, Xin-Yun.

Assessment of metabolic changes in Acinetobacter johnsonii and Pseudomonas fluorescens co-culture from bigeye tuna (Thunnus obesus) spoilage by ultra-high-performance liquid chromatography-tandem mass spectrometry

Acinetobacter johnsonii and Pseudomonas fluorescens are specific spoilage microorganisms (SSO) of aquatic products, and their metabolites are effective indicators for analyzing these two SSOs. However, the metabolome of a coculture of A. johnsonii and P. fluorescens is still unclear. The aim of this study was to investigate the metabolomic changes in A. johnsonii, P. fluorescens, and their co-culture by screening for metabolic markers. PCA and PLS-DA revealed that A, P, and AP groups were different from each other, indicating a significantly varying metabolic profile among them. Based on UHPLC information, 540 metabolites with significant differences, were identified in the ESI+ and ESI- modes, which covered 79 metabolic pathways. The different metabolites were mainly related to the pathways, such as taurine and hypotaurine metabolism:M, bile secretion:OS, and arginine biosynthesis:M were in the A vs AP group, while PPAR signaling pathway:OS, tropane, piperidine, and pyridine alkaloid biosynthesis:M, longevity regulating pathway-worm:OS, choline metabolism in cancer:HD, biosynthesis of phenylpropanoids:M, and amoebiasis:HD were in the P vs AP group. Therefore, this study may provide significant information regarding the metabolic mechanisms of A. johnsonii, P. fluorescens, and their co-cultures, which may provide insights on their role in deteriorating the quality of aquatic products.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 179474-79-4, in my other articles. Product Details of 179474-79-4.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 179474-79-4, Name is 1-(3-Methoxypropyl)piperidin-4-amine. In a document, author is Novanna, Motakatla, introducing its new discovery. Application In Synthesis of 1-(3-Methoxypropyl)piperidin-4-amine.

Microwave-Assisted N-Allylation/Homoallylation-RCM Approach: Access to Pyrrole-, Pyridine-, or Azepine-Appended (Het)aryl Aminoamides

A facile and diversity-oriented approach has been developed for the synthesis of pyrrole-, pyridine-, or azepine-appended (het)aryl aminoamides via the N-allylation/homoallylation-ring-closing metathesis (RCM) strategy. Microwave condition was efficiently utilized for N-allylation of (het)aryl aminoamides to synthesize di-, tri-, and tetra-allyl/homoallylated RCM substrates in good yields. All of the RCM substrates were successfully converted to respective pyrroles 6a-h, 13a,b, 15a,b, pyridines 11a-d, 13c, and azepines 7a,b via RCM. All of the five-, six-, and seven-membered N-heterocycles were synthesized in shorter reaction times with excellent yields without isomerization products. A one-pot reaction to synthesize compounds 6a and 6b without isolating corresponding RCM substrates was achieved successfully. The synthetic utility of the compound 6b has been demonstrated by synthesizing biaryl derivatives 17a,b under the microwave Suzuki coupling reaction condition.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 179474-79-4 help many people in the next few years. Application In Synthesis of 1-(3-Methoxypropyl)piperidin-4-amine.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, SDS of cas: 179474-79-4, 179474-79-4, Name is 1-(3-Methoxypropyl)piperidin-4-amine, SMILES is COCCCN1CCC(N)CC1, belongs to piperidines compound. In a document, author is Thies, Ruediger, introduce the new discover.

Iron azaphthalocyanines with axial ligands

The syntheses of the iron azaphthalocyanines Tetra(2,3-pyrido) porphyrazinato-iron, T(2,3-Py)PFe (1), Tetra(3,4-pyrido) porphyrazinato-iron, T(3,4-Py)PFe (2), Tetrapyrazoporphyrazinatoiron, TPzPFe (3), Tetratertbutyltetrapyrazoporphyrazinato-iron tbu(4) TPzPFe (4) is reported. They react with the monodentate pyridine, substituted pyridines, piperidine (pip) and various isontriles to form the corresponding bis-axially substituted porphyrazinato-iron compounds McFeL(2). Bidentate ligands. e.g. pyrazine (pyz) or diisocyanobenzene (dib), form the polymeric adducts, e.g. [T(2,3-Py)pyz](n) or [T(2,3 Py)PFedib](n). The spectroscopic data (H-1-NMR, IR, UV-vis, Mossbauer) are reported and compared with the analogous phthalocyaninato- iron compounds.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 179474-79-4. SDS of cas: 179474-79-4.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 179474-79-4, Name is 1-(3-Methoxypropyl)piperidin-4-amine, SMILES is COCCCN1CCC(N)CC1, in an article , author is Lee, Chang-Hee, once mentioned of 179474-79-4, Recommanded Product: 179474-79-4.

Chelation-Assisted C-H and C-C Bond Activation of Allylic Alcohols by a Rh(I) Catalyst under Microwave Irradiation

Chelation-assisted Rh(I)-catalyzed ketone synthesis from allylic alcohols and alkenes through C-H and C-C bond activations under microwave irradiation was developed. Aldimine is formed via olefin isomerization of allyl alcohol under Rh(I) catalysis and condensation with 2-amino-3-picoline, followed by continuous C-H and C-C bond activations to produce a dialkyl ketone. The addition of piperidine accelerates the reaction rate by promoting aldimine formation under microwave conditions.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 179474-79-4, you can contact me at any time and look forward to more communication. Recommanded Product: 179474-79-4.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

In an article, author is Zhao, Yanmei, once mentioned the application of 179474-79-4, Name is 1-(3-Methoxypropyl)piperidin-4-amine, molecular formula is C9H20N2O, molecular weight is 172.27, MDL number is MFCD11104531, category is piperidines. Now introduce a scientific discovery about this category, Quality Control of 1-(3-Methoxypropyl)piperidin-4-amine.

Optimization of piperidine constructed peptidyl derivatives as proteasome inhibitors

A series of non-covalent piperidine-containing peptidyl derivatives with various substituents at side chains of different residues were designed, synthesized and evaluated as proteasome inhibitors. After proteasome inhibitory evaluations of all the synthesized target compounds, selected ones were tested for their anti-proliferation activities against three multiple myeloma (MM) cell lines. 8 analogues displayed more potent activities than carfilzomib, and the most promising compound 24 showed IC50 values of 0.8 +/- 0.2 nM against 20S proteasome and 8.42 +/- 0.74 nM, 7.14 +/- 0.52 nM, 14.20 +/- 1.08 nM for RPMI 8226, NCI-H929 and MM.1S cell lines, respectively. Additionally, mechanisms of anti-cancer activity of representative compound 24 were further investigated. Apoptosis of RPMI-8226 cells were achieved through accumulating polyubiquitin and inducing the cleavage of caspase and PARP. Besides, half-life in rat plasma of compound 24 was prolonged after optimization, which would be helpful for increasing in vivo activities of this series of derivatives. All the studies confirmed that piperidine-containing non-covalent proteasome inhibitors can be potential leads for anti-MM drug development.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

179474-79-4, Name is 1-(3-Methoxypropyl)piperidin-4-amine, molecular formula is C9H20N2O, belongs to piperidines compound, is a common compound. In a patnet, author is Gu, He, once mentioned the new application about 179474-79-4, Recommanded Product: 1-(3-Methoxypropyl)piperidin-4-amine.

Total Synthesis of (-)-Lepadin F based on a Stereoselective Diels-Alder Reaction Controlled by a Ketolactone-type Dienophile

An efficient approach to the type III lepadin alkaloids (lepadins F and G) has been developed through a key Diels-Alder reaction, in which a novel ketolactone-type dienophile with chiral diol unit is employed to generate the desirable all-cis-trisubstituted cyclohexene with excellent regio- and stereoselectivity control. The subsequent selective sulfonylation of the diol unit followed by S(N)2 cyclization under hydrogenation conditions could construct the substituted piperidine ring. By using this approach, (-)-lepadin F is synthesized from ethyl l-lactate for the first time.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 179474-79-4, Name is 1-(3-Methoxypropyl)piperidin-4-amine, molecular formula is C9H20N2O. In an article, author is Olsson, Joel S.,once mentioned of 179474-79-4, Product Details of 179474-79-4.

Functionalizing Polystyrene with N-Alicyclic Piperidine-Based Cations via Friedel-Crafts Alkylation for Highly Alkali-Stable Anion-Exchange Membranes

Different anion-exchange membranes (AEMs) based on polystyrene (PS)-carrying benzyltrimethyl ammonium cations are currently being developed for use in alkaline fuel cells and water electrolyzers. However, the stability in relation to these state-of-the-art cations needs to be further improved. Here, we introduce highly alkali-stable mono- and spirocyclic piperidine-based cations onto PS by first performing a superacid-mediated Friedel-Crafts alkylation using 2-(piperidine-4-yl)propane-2-ol. This is followed by quaternization of the piperidine rings either using iodomethane to produce N,N-dimethyl piperidinium cations or by cyclo-quaternizations using 1,5-dibromopentane and 1,4-dibromobutane, respectively, to obtain N-spirocyclic quaternary ammonium cations. Thus, it is possible to functionalize up to 27% of the styrene units with piperidine rings and subsequently achieve complete quaternization. The synthetic approach ensures that all of the sensitive beta-hydrogens of the cations are present in ring structures to provide high stability. AEMs based on these polymers show high alkaline stability and less than 5% ionic loss was observed by H-1 NMR spectroscopy after 30 days in 2 M aq NaOH at 90 degrees C. AEMs functionalized with N,N-dimethyl piperidinium cations show higher stability than the ones carrying N-spirocyclic quaternary ammonium. Careful analysis of the latter revealed that the rings formed in the cyclo-quaternization are more prone to degrade via Hofmann elimination than the rings introduced in the Friedel-Crafts reaction. AEMs with an ion-exchange capacity of 1.5 mequiv g(-1) reach a hydroxide conductivity of 106 mS cm(-1) at 80 degrees C under fully hydrated conditions. The AEMs are further tuned and improved by blending with polybenzimidazole (PBI). For example, an AEM containing 2 wt % PBI shows reduced water uptake and much improved robustness during handling and reaches 71 mS cm(-1) at 80 degrees C. The study demonstrates that the critical alkaline stability of PS-containing AEMs can be significantly enhanced by replacing the benchmark benzyltrimethyl ammonium cations with N-alicyclic piperidine-based cations.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 179474-79-4, Name is 1-(3-Methoxypropyl)piperidin-4-amine, molecular formula is C9H20N2O. In an article, author is Zhi, Zhuoer,once mentioned of 179474-79-4, COA of Formula: C9H20N2O.

Discovery of Aryl Formyl Piperidine Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase Inhibitors

Most of the current monoacylglycerol lipase (MAGL) inhibitors function by an irreversible mechanism of action, causing a series of side effects. Herein, starting from irreversible inhibitors, 25 compounds were synthesized and evaluated in vitro for MAGL inhibition, among which, compound 36 showed the most potent inhibitory activity (IC50 = 15 nM). Crucially, docking studies demonstrated that the m-chlorine-substituted aniline fragment occupied a hydrophobic subpocket enclosed by side chains of Val191, Tyr194, Val270, and Lys273, which creatively identify a new key anchoring point for the development of new MAGL inhibitors. Furthermore, in vivo evaluation innovatively revealed that this reversible inhibitor 36 significantly ameliorated depressive-like behaviors induced by reserpine. To the best of our knowledge, this is the first time that reversible inhibitors of MAGL were developed to support MAGL as a potential therapeutic target for depression.

Interested yet? Keep reading other articles of 179474-79-4, you can contact me at any time and look forward to more communication. COA of Formula: C9H20N2O.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 179474-79-4, Name is 1-(3-Methoxypropyl)piperidin-4-amine, SMILES is COCCCN1CCC(N)CC1, belongs to piperidines compound. In a document, author is Tanuma, Sei-ichi, introduce the new discover, Safety of 1-(3-Methoxypropyl)piperidin-4-amine.

Structural Basis of Beneficial Design for Effective Nicotinamide Phosphoribosyltransferase Inhibitors

Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) is an attractive therapeutic strategy for targeting cancer metabolism. So far, many potent NAMPT inhibitors have been developed and shown to bind to two unique tunnel-shaped cavities existing adjacent to each active site of a NAMPT homodimer. However, cytotoxicities and resistances to NAMPT inhibitors have become apparent. Therefore, there remains an urgent need to develop effective and safe NAMPT inhibitors. Thus, we designed and synthesized two close structural analogues of NAMPT inhibitors, azaindole-piperidine (3a)- and azaindole-piperazine (3b)-motif compounds, which were modified from the well-known NAMPT inhibitor FK866 (1). Notably,3adisplayed considerably stronger enzyme inhibitory activity and cellular potency than did3band1. The main reason for this phenomenon was revealed to be due to apparent electronic repulsion between the replaced nitrogen atom (N1) of piperazine in3band the N delta atom of His191 in NAMPT by our in silico binding mode analyses. Indeed,3bhad a lower binding affinity score than did3aand1, although these inhibitors took similar stable chair conformations in the tunnel region. Taken together, these observations indicate that the electrostatic enthalpy potential rather than entropy effects inside the tunnel cavity has a significant impact on the different binding affinity of3afrom that of3bin the disparate enzymatic and cellular potencies. Thus, it is better to avoid or minimize interactions with His191 in designing further effective NAMPT inhibitors.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 179474-79-4 is helpful to your research. Safety of 1-(3-Methoxypropyl)piperidin-4-amine.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem