Category: 179474-79-4

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 179474-79-4, Name is 1-(3-Methoxypropyl)piperidin-4-amine, SMILES is COCCCN1CCC(N)CC1, belongs to piperidines compound. In a document, author is Tanuma, Sei-ichi, introduce the new discover, COA of Formula: C9H20N2O.

Inhibition of nicotinamide phosphoribosyltransferase (NAMPT) is an attractive therapeutic strategy for targeting cancer metabolism. So far, many potent NAMPT inhibitors have been developed and shown to bind to two unique tunnel-shaped cavities existing adjacent to each active site of a NAMPT homodimer. However, cytotoxicities and resistances to NAMPT inhibitors have become apparent. Therefore, there remains an urgent need to develop effective and safe NAMPT inhibitors. Thus, we designed and synthesized two close structural analogues of NAMPT inhibitors, azaindole-piperidine (3a)- and azaindole-piperazine (3b)-motif compounds, which were modified from the well-known NAMPT inhibitor FK866 (1). Notably,3adisplayed considerably stronger enzyme inhibitory activity and cellular potency than did3band1. The main reason for this phenomenon was revealed to be due to apparent electronic repulsion between the replaced nitrogen atom (N1) of piperazine in3band the N delta atom of His191 in NAMPT by our in silico binding mode analyses. Indeed,3bhad a lower binding affinity score than did3aand1, although these inhibitors took similar stable chair conformations in the tunnel region. Taken together, these observations indicate that the electrostatic enthalpy potential rather than entropy effects inside the tunnel cavity has a significant impact on the different binding affinity of3afrom that of3bin the disparate enzymatic and cellular potencies. Thus, it is better to avoid or minimize interactions with His191 in designing further effective NAMPT inhibitors.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 179474-79-4 is helpful to your research. COA of Formula: C9H20N2O.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Talavera-Aleman, Armando, once mentioned the application of 179474-79-4, Name is 1-(3-Methoxypropyl)piperidin-4-amine, molecular formula is C9H20N2O, molecular weight is 172.27, MDL number is MFCD11104531, category is piperidines. Now introduce a scientific discovery about this category, Product Details of 179474-79-4.

Synthesis of Nitrogen- and Oxygen-Containing Heterocycles by Prins Cyclization in Continuous Flow

Aza-silyl-Prins and oxa-Prins cyclization reactions in continuous-flow chemistry are described for the synthesis of the corresponding tetrahydropyridines and pyran derivatives, respectively. In particular, the use of pyridine-carboxaldehydes for aza-silyl-Prins reaction led to either a symmetrical triarylmethane or two new bicyclic compounds. 4-Fluorinated-2-substituted tetrahydropyran derivatives were also obtained in the oxa-Prins cyclization with good selectivity in favor of the anti-isomer.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 179474-79-4, Name is 1-(3-Methoxypropyl)piperidin-4-amine, molecular formula is , belongs to piperidines compound. In a document, author is Silva, Debora E. S., SDS of cas: 179474-79-4.

Silver(I) complexes of 3-methoxy-4-hydroxybenzaldehyde thiosemicarbazones and triphenylphosphine: structural, cytotoxicity, and apoptotic studies

Novel silver(i) complexes of the type [AgCl(PPh3)(2)(L)] {PPh3 = triphenylphosphine; L = VTSC = 3-methoxy-4-hydroxybenzaldehyde thiosemicarbazone (1); VMTSC = 3-methoxy-4-[2-(morpholine-1-yl)ethoxy]benzaldehyde thiosemicarbazone (2); VPTSC = 3-methoxy-4-[2-(piperidine-1-yl)ethoxy]benzaldehyde thiosemicarbazone (3)} were synthesized and fully characterized by spectroscopic techniques. The molecular structures of complexes 2 and 3 were determined by single crystal X-ray diffraction. Compounds 1-3 exhibited appreciable cytotoxic activity against human tumor cells (lung A549, breast MDA-MB-231 and MCF-7) with IC50 values in 48 h of incubation ranging from 5.6 to 18 mu M. Cellular uptake studies showed that complexes 1-3 were efficiently internalized after 3 hours of treatment in MDA-MB-231 cells. The effects of complex 1 on the cell morphology, cell cycle, induction of apoptosis, mitochondrial membrane potential (Delta psi(m)), and reactive oxygen species (ROS) production have been evaluated in triple negative breast cancer (TNBC) cells MDA-MB-231. Our results showed that complex 1 induced typical morphological alterations of cell death, an increase in cells at the sub-G1 phase, apoptosis, and mitochondrial membrane depolarization. Furthermore, DNA binding studies evidenced that 1 can bind to ct-DNA and does so without modifying the B-structure of the DNA, but that the binding is weak compared to that of Hoechst 33258.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 179474-79-4, in my other articles. SDS of cas: 179474-79-4.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry is an experimental science, SDS of cas: 179474-79-4, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 179474-79-4, Name is 1-(3-Methoxypropyl)piperidin-4-amine, molecular formula is C9H20N2O, belongs to piperidines compound. In a document, author is Gomes do Nascimento, Michelle Nauara.

Antimicrobial and cytotoxic activities of Senna and Cassia species (Fabaceae) extracts

In Brazilian traditional medicine, botanical species belonging to the genera Senna and Cassia are widely used as laxative, analgesic, and antifungal agents to treat ringworm and other fungal skin infections. This has motivated us to select and to screen ten species of these genera for their antibacterial, antifungal, and cytotoxic activities. The leaf or flower ethanol extracts were investigated against aerobic and anaerobic oral bacteria and Candida spp.; the microdilution broth method was employed. Cytotoxicity was determined against Vero cells. Among the plant extracts evaluated herein, four extracts at 200.0-400.0 mu g mL(-1) presented moderate activities against at least two bacterial strains. Concerning the antifungal action, the S. macranthera flower ethanol extract exerted significant antifungal effect with MIC values ranging from 5.9 to 23.4 mu g mL(-1). This extract was submitted to liquid-liquid extraction, and the resulting fractions were tested. The ethyl acetate fraction showed better antifungal activity (MIC values of 5.9 mu g mL(-1) for C. glabrata and 23.4 mu g mL(-1) for C. albicans and C. tropicalis) as compared with amphotericin B (0.1-0.2 mu g mL(-1)), used as positive control. The bioactive metabolites of this fraction were identified by UHPLC-ESI/HRMS/MSn, which revealed the presence of eighteen compounds, including one organic acid (1), two flavan-3-ol (2 and 3), one flavone (4), two glycosylated flavonols (5 and 6), five proanthocyanidin dimers (7-11b), and seven proanthocyanidin trimers (12-18). The antimicrobial activities of some Senna or Cassia species studied here have been reported for the first time. The present results show that S. macranthera flowers are an interesting source of new antifungal agents.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 179474-79-4. SDS of cas: 179474-79-4.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 179474-79-4, Name is 1-(3-Methoxypropyl)piperidin-4-amine, formurla is C9H20N2O. In a document, author is Bhuma, Naresh, introducing its new discovery. Product Details of 179474-79-4.

Fluorinated piperidine iminosugars and their N-alkylated derivatives: Synthesis, conformational analysis, immunosuppressive and glycosidase inhibitory activity studies

The fluorinated piperidine iminosugars 2a-4a and their N-octyl and N-decyl derivatives 2b,c-4b,c were synthesized from D-mannoseio-xylose using nucleophilic fluorination as the key step. The conformation of iminosugars 2/3, either C-2(5) or C-5(2), was assigned based on the H-1 NMR studies at different pH. immunomodulatory activity of 2a,c-4a,c was examined using Mixed Lymphocyte Reaction (MLR) and B-cell assay. The N-alkylated fluorinated D-manno-iminosugars 3b/4b were found to be better immunosuppressive agents (IC50=5-6 mu M) on T-cells. The fluorinated iminosugar 3a/4a act as potent and selective inhibitors of beta-glucosidase (IC50= 4-8 mu M). The N-alkyl-iminosugars 4b-c were found to be moderate inhibitors of alpha-glucosidase (yeast) and a-galactosidase (coffee beans), respectively. (C) 2018 Elsevier Ltd. All rights reserved.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 179474-79-4, Name is 1-(3-Methoxypropyl)piperidin-4-amine, SMILES is COCCCN1CCC(N)CC1, in an article , author is Qi, Xiaoxu, once mentioned of 179474-79-4, Recommanded Product: 179474-79-4.

Enantioselective Pd(II)-Catalyzed Intramolecular Oxidative 6-endo Aminoacetoxylation of Unactivated Alkenes

A novel asymmetric 6-endo aminoacetoxylation of unactivated alkenes by palladium catalysis, which yields chiral beta-acetoxylated piperidines with excellent chemo-, regio- and enantioselectivities under very mild reaction conditions, has been established herein by employing a new designed pyridine-oxazoline (Pyox) ligand. Importantly, introducing a sterically bulky group into the C-6 position of Pyox is crucial to enhance the reactivity of the aminoacetoxylation of alkenes.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Let’s face it, organic chemistry can seem difficult to learn, Safety of 1-(3-Methoxypropyl)piperidin-4-amine, Especially from a beginner’s point of view. Like 179474-79-4, Name is 1-(3-Methoxypropyl)piperidin-4-amine, molecular formula is piperidines, belongs to piperidines compound. In a document, author is Stumpf, Tim-Daniel J., introducing its new discovery.

C-Bridged Bispyrrolidines and Bispiperidines as New Ligands

The preparation of methylene-bridged C-2-symmetric nitrogen-heterocycles as a new class of ligands is described, including methylene-bridged pyridines, quinolones, piperidines and pyrrolidines. These methylene-bridged aromatic systems are obtained via a microwave assisted Ziegler-type reaction. The separation of diastereomers and the application of the copper complexes of these ligands for cyclopropanation reactions proves the applicability of these new types of ligands.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 179474-79-4, Name is 1-(3-Methoxypropyl)piperidin-4-amine, molecular formula is , belongs to piperidines compound. In a document, author is Asmafiliz, Nuran, Application In Synthesis of 1-(3-Methoxypropyl)piperidin-4-amine.

Phosphorus-nitrogen compounds. Part 41. Ferrocenyl pendant-armed spirocyclopiperidinocyclotriphosphazatrienes: Langmuir-Blodgett thin films and biological activity studies

The Cl replacement reactions of N/N or N/O spirocyclic monoferrocenylcyclotriphosphazatrienes (1-5) with the piperidine resulted in the geminal- (6-10) and tetra-piperidinophosphazenes with monoferrocenyl pendant arm (11-15). The structures of all the new compounds were determined using spectroscopic techniques. The ultrathin Langmuir-Blodgett (LB) films of two compounds (3 and 12) were prepared. The characterization of the LB films using p-polarized grazing angle (GAIR) and horizontal attenuated total reflectance (HATR) techniques was carried out. The molecular and crystal structure of the compound 6 was examined using X-ray crystallography. In addition, the interactions between six compounds (6, 7, 11, 12, 14 and 15) and pBR322 plasmid DNA were investigated by agarose gel electrophoresis.Graphical AbstractSYNOPSIS The ultrathin Langmuir-Blodgett (LB) films of two of these compounds were prepared. Molecular and crystal structure of a representative example was determined. In addition, the interactions between several of these with pBR322 plasmid DNA were investigated by agarose gel electrophoresis.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 179474-79-4, in my other articles. Application In Synthesis of 1-(3-Methoxypropyl)piperidin-4-amine.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 179474-79-4, Name is 1-(3-Methoxypropyl)piperidin-4-amine, SMILES is COCCCN1CCC(N)CC1, belongs to piperidines compound. In a document, author is Shakhmaev, R. N., introduce the new discover, Recommanded Product: 1-(3-Methoxypropyl)piperidin-4-amine.

Pd-Cu-Catalyzed Synthesis of Alk-5-en-7-yn-2-ones

Stereoselective synthesis of (E)- and (Z)-alk-5-en-7-in-2-ones was performed by cross-coupling of alkynes with 6-chlorohex-5-en-2-one stereoisomers in the presence of PdCl2(PrCN)(2) complex and CuI in piperidine.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 179474-79-4 is helpful to your research. Recommanded Product: 1-(3-Methoxypropyl)piperidin-4-amine.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Reference of 179474-79-4, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 179474-79-4, Name is 1-(3-Methoxypropyl)piperidin-4-amine, SMILES is COCCCN1CCC(N)CC1, belongs to piperidines compound. In a article, author is Li, Wei-Sian, introduce new discover of the category.

Enantioselective Rhodium-Catalyzed Allylation of Aliphatic Imines: Synthesis of Chiral C-Aliphatic Homoallylic Amines

Reported herein is a method for the efficient syntheses of optically active 1-alkyl homoallylic amines in yields up to 95%, 13.5:1 dr, and 98% ee under mild, aqueous reaction conditions, via the Rh-catalyzed asymmetric allylation of aliphatic aldimines. This method provides a streamlined synthetic platform for the preparation of indolizidine and piperidine alkaloids, thus demonstrating its usefulness.

Reference of 179474-79-4, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 179474-79-4 is helpful to your research.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem