Category: 177-11-7

An article Mono- and dispirocyclotriphosphazenes containing 4-bromobenzyl pendant arm(s): Synthesis, spectroscopy, crystallography and biological activity studies WOS:000573639200004 published article about PHOSPHORUS-NITROGEN COMPOUNDS; DNA INTERACTIONS; STRUCTURAL INVESTIGATIONS; CYTOTOXIC ACTIVITIES; PHOSPHAZENES; DERIVATIVES; SPIRO in [Kuzey, Nur Guven; Ozgur, Mehtap; Cemaloglu, Resit; Asmafiliz, Nuran; Kilic, Zeynel] Ankara Univ, Dept Chem, TR-06100 Ankara, Turkey; [Acik, Leyla; Aydin, Betul] Gazi Univ, Dept Biol, TR-06500 Ankara, Turkey; [Hokelek, Tuncer] Hacettepe Univ, Dept Phys, TR-06800 Ankara, Turkey in 2020, Cited 40. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Product Details of 177-11-7

The N/N donor-type bromobenzyldiamines (1-3) were successively prepared by reduction of Schiff bases formed as a result of condensation reactions of 4-bromobenzaldehyde with aliphatic diamines. The Cl exchange reactions of hexachlorocyclotriphosphazene (HCCP; trimer; N3P3Cl6; 4) with the bidentate ligands (1-3) produced the new monospiro- (5-7) and dispirocyclotriphosphazenes (8-13) containing 4-bromo-benzyl pendant arm(s). The tetrachloro phosphazenes (5-7) were reacted with pyrrolidine, tetra-1,4-dioxa-8-azaspiro [4.5]decane (DASD) and piperidine to give the tetraamino substituted mono-spirophosphazenes (5a-7c). The spectral analyses of all the phosphazenes were made using appropriate spectroscopic methods; such as FTIR, H-1, C-13, P-31 NMR and ESI-MS. The molecular and crystal structures of 5, 6, 7 and 12 were also determined by X-ray crystallography. On the other hand, the antimicrobial activities of the phosphazenes were evaluated against G (-) and G (+) bacteria and fungi. Some of the tetraaminophosphazenes were found to be very active against several bacteria and fungi. Besides, the interactions of the cyclotriphosphazenes with plasmid DNA were investigated using agarose gel electrophoresis. (C) 2020 Elsevier B.V. All rights reserved.

Product Details of 177-11-7. Bye, fridends, I hope you can learn more about C7H13NO2, If you have any questions, you can browse other blog as well. See you lster.

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Product Details of 177-11-7. In 2019 EUR J MED CHEM published article about ACUTE MYELOID-LEUKEMIA; RISK MYELODYSPLASTIC SYNDROME; ACUTE MYELOGENOUS LEUKEMIA; TYROSINE KINASE; ACTIVATING MUTATION; TANDEM DUPLICATION; WILD-TYPE; IN-VITRO; PHASE-I; RECEPTOR in [Baska, Ferenc; Sipos, Anna; Nemes, Zoltan; Dobos, Judit; Szantai-Kis, Csaba; Garamvolgyi, Rita; Orfi, Laszlo] Vichem Chem Res Ltd, H-1022 Budapest, Hungary; [Orfi, Zoltan] Max Planck Inst Biochem, Dept Mol Biol, D-82152 Martinsried, Germany; [Szabo, Eszter] Semmelweis Univ, Dept Paediat 1, H-1083 Budapest, Hungary; [Szenasi, Gabor; Dezsi, Laszlo; Hamar, Peter] Semmelweis Univ, Inst Pathophysiol, H-1089 Budapest, Hungary; [Dezsi, Laszlo] Semmelweis Univ, Nanomed Res & Educ Ctr, H-1089 Budapest, Hungary; [Cserepes, Mihaly T.; Tovari, Jozsef] Natl Inst Oncol, Dept Expt Pharmacol, H-1122 Budapest, Hungary; [Kreko, Marcell; Orfi, Laszlo] Semmelweis Univ, Dept Pharmaceut Chem, Hogyes Endre U 9, H-1085 Budapest, Hungary; [Orfi, Laszlo] Drug Res Co, Batthyany U 92, H-1161 Budapest, Hungary in 2019, Cited 62. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

Aberrant activation of FMS-like tyrosine receptor kinase 3 (FLT3) is implicated in the pathogenesis of acute myeloid leukemia (AML) in 20-30% of patients. In this study we identified a highly selective (phenylethenyl)quinazoline compound family as novel potent inhibitors of the FLT3-ITD and FLT3-D835Y kinases. Their prominent effects were confirmed by biochemical and cellular proliferation assays followed by mice xenograft studies. Our modelling experiments and the chemical structures of the compounds predict the possibility of covalent inhibition. The most effective compounds triggered apoptosis in FLT3-ITD AML cells but had either weak or no effect in FLT3-independent leukemic and non-leukemic cell lines. Our results strongly suggest that our compounds may become therapeutics in relapsing and refractory AML disease harboring various ITD and tyrosine kinase domain mutations, by their ability to overcome drug resistance. (C) 2019 Elsevier Masson SAS. All rights reserved.

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Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

In 2020 CRIT CARE published article about PROPORTIONAL ASSIST VENTILATION; MECHANICAL VENTILATION; INSPIRATORY PRESSURE; ELECTRICAL-ACTIVITY; ESOPHAGEAL; IMPACT; INJURY; VOLUME; SLEEP; EVOLUTION in [Di Mussi, Rosa; Pisani, Luigi; Iannuzziello, Rachele; Dalfino, Lidia; Murgolo, Francesco; Grasso, Salvatore] Univ Bari Aldo Moro, Osped Policlin, Dipartimento Emergenza & Trapianti Organo DETO, Sez Anestesiol & Rianimaz, Piazza Giulio Cesare 11, Bari, Italy; [Spadaro, Savino; Volta, Carlo Alberto] Univ Ferrara, Dipartimento Morfol Chirurg & Med Sperimentale, Sez Anestesiol & Terapia Intens Univ, Ferrara, Italy; [Bartolomeo, Nicola; Trerotoli, Paolo] Univ Aldo Moro, Dipartimento Sci Biomed & Oncol Umana, Cattedra Stat Med, Bari, Italy; [Staffieri, Francesco] Univ Bari Aldo Moro, Dipartimento Emergenza & Trapianti Organo DETO, Sez Chirurg Vet, Bari, Italy in 2020, Cited 67. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Category: piperidines

Introduction Pressure support ventilation (PSV) should allow spontaneous breathing with a normal neuro-ventilatory drive. Low neuro-ventilatory drive puts the patient at risk of diaphragmatic atrophy while high neuro-ventilatory drive may causes dyspnea and patient self-inflicted lung injury. We continuously assessed for 12 h the electrical activity of the diaphragm (EAdi), a close surrogate of neuro-ventilatory drive, during PSV. Our aim was to document the EAdi trend and the occurrence of periods of Low and/or High neuro-ventilatory drive during clinical application of PSV. Method In 16 critically ill patients ventilated in the PSV mode for clinical reasons, inspiratory peak EAdi peak (EAdi(PEAK)), pressure time product of the trans-diaphragmatic pressure per breath and per minute (PTPDI/b and PTPDI/min, respectively), breathing pattern and major asynchronies were continuously monitored for 12 h (from 8 a.m. to 8 p.m.). We identified breaths with Normal (EAdi(PEAK) 5-15 mu V), Low (EAdi(PEAK) < 5 mu V) and High (EAdi(PEAK) > 15 mu V) neuro-ventilatory drive. Results Within all the analyzed breaths (177.117), the neuro-ventilatory drive, as expressed by the EAdi(PEAK), was Low in 50.116 breath (28%), Normal in 88.419 breaths (50%) and High in 38.582 breaths (22%). The average times spent in Low, Normal and High class were 1.37, 3.67 and 0.55 h, respectively (p < 0.0001), with wide variations among patients. Eleven patients remained in the Low neuro-ventilatory drive class for more than 1 h, median 6.1 [3.9-8.5] h and 6 in the High neuro-ventilatory drive class, median 3.4 [2.2-7.8] h. The asynchrony index was significantly higher in the Low neuro-ventilatory class, mainly because of a higher number of missed efforts. Conclusions We observed wide variations in EAdi amplitude and unevenly distributed Low and High neuro ventilatory drive periods during 12 h of PSV in critically ill patients. Further studies are needed to assess the possible clinical implications of our physiological findings. Category: piperidines. Welcome to talk about 177-11-7, If you have any questions, you can contact Di Mussi, R; Spadaro, S; Volta, CA; Bartolomeo, N; Trerotoli, P; Staffieri, F; Pisani, L; Iannuzziello, R; Dalfino, L; Murgolo, F; Grasso, S or send Email.

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Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Design and Synthesis of a Novel and Selective Kappa Opioid Receptor (KOR) Antagonist (BTRX-335140) WOS:000460365600004 published article about AGONIST SALVINORIN; PROLACTIN; DYNORPHIN; LY2456302; DOPAMINE; STRESS; 2-METHYL-N-((2′-(PYRROLIDIN-1-YLSULFONYL)BIPHENYL-4-YL)METHYL)PROPAN-1-AMINE; EXPRESSION; DISCOVERY; BINDING in [Guerrero, Miguel; Urbano, Mariangela; Kim, Eun-Kyong; Gamo, Ana M.; Riley, Sean; Abgaryan, Lusine; Leaf, Nora; Brown, Steven J.; Rosen, Hugh; Roberts, Edward] Scripps Res Inst, Dept Mol Med, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA; [Van Orden, Lori Jean] BlackThorn Therapeut Inc, 780 Brannan St, San Francisco, CA 94103 USA; [Xie, Jennifer Y.; Porreca, Frank] Univ Arizona, Dept Pharmacol, Tucson, AZ 85724 USA; [Cameron, Michael D.] Scripps Res Inst, Dept Mol Med, Jupiter, FL 33458 USA; [Xie, Jennifer Y.] Arkansas State Univ, Coll Osteopath Med, New York Inst Technol, Dept Basic Sci, Jonesboro, AR 72446 USA in 2019, Cited 47. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. SDS of cas: 177-11-7

kappa opioid receptor (KOR) antagonists are potential pharmacotherapies for the treatment of migraine and stress-related mood disorders including depression, anxiety, and drug abuse, thus the development of novel KOR antagonists with an improved potency/selectivity profile and medication-like duration of action has attracted the interest of the medicinal chemistry community. In this paper, we describe the discovery of 1-(6-ethyl-8-fluoro-4-methyl-3-(3-methyl-1,2,4-oxadiazol-5-yl)quinolin-2-yl)-N-(tetrahydro-2 H-pyran-4-yl)piperidin-4 amine (CYM-53093, BTRX-335140) as a potent and selective KOR antagonist, endowed with favorable in vitro ADMET and in vivo pharmacokinetic profiles and medication-like duration of action in rat pharmacodynamic experiments. Orally administered CYM-53093 showed robust efficacy in antagonizing KOR agonist-induced prolactin secretion and in tail-flick analgesia in mice. CYM-53093 exhibited a broad selectivity over a panel of off-target proteins. This compound is in phase 1 clinical trials for the treatment of neuropsychiatric disorders wherein dynorphin is thought to contribute to the underlying pathophysiology.

SDS of cas: 177-11-7. Welcome to talk about 177-11-7, If you have any questions, you can contact Guerrero, M; Urbano, M; Kim, EK; Gamo, AM; Riley, S; Abgaryan, L; Leaf, N; Van Orden, LJ; Brown, SJ; Xie, JY; Porreca, F; Cameron, MD; Rosen, H; Roberts, E or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Product Details of 177-11-7. Zeng, L; Li, HR; Hu, JC; Zhang, DC; Hu, JY; Peng, P; Wang, SC; Shi, RY; Peng, JQ; Pao, CW; Chen, EL; Lee, JF; Zhang, H; Chen, YH; Lei, AW in [Zeng, Li; Li, Haoran; Hu, Jingcheng; Zhang, Dongchao; Hu, Jiayu; Peng, Pan; Wang, Shenchun; Shi, Renyi; Peng, Jiaqi; Zhang, Heng; Chen, Yi-Hung; Lei, Aiwen] Wuhan Univ, Coll Chem & Mol Sci, IAS, Wuhan, Peoples R China; [Pao, Chih-Wen; Chen, Jeng-Lung; Lee, Jyh-Fu] Natl Synchrotron Radiat Res Ctr, Hsinchu, Taiwan published Electrochemical oxidative aminocarbonylation of terminal alkynes in 2020, Cited 44. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

Oxidative carbonylation using CO/O-2 is an attractive strategy to construct carbonyl compounds, but the explosive limit of the gas mixture hampers its application. Now, this safety issue is overcome in the aminocarbonylation of alkynes by replacing the external oxidant O-2 by electrochemistry facilitating a mild and safe reaction. Palladium-catalysed oxidative carbonylation using oxygen as the oxidant is an economical approach; however, the gas mixture of CO and air has an explosive limit of 12.5-74.0% that could hamper extensive application of this process. Herein we report an electrochemical aminocarbonylation of alkynes under atmospheric pressure in an undivided cell without an external oxidant. The transformation has a broad substrate scope (83 examples) that involves primary amines and ammonium salts. Furthermore, mechanistic studies through cyclic voltammetry, in situ infrared and quick-scanning X-ray absorption fine structure spectroscopy reveal the reasons for this protocol proceeding smoothly under electrochemical conditions.

Product Details of 177-11-7. Bye, fridends, I hope you can learn more about C7H13NO2, If you have any questions, you can browse other blog as well. See you lster.

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Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Asmafiliz, N; Berberoglu, I; Ozgur, M; Kilic, Z; Kayalak, H; Acik, L; Turk, M; Hokelek, T in [Asmafiliz, Nuran; Berberoglu, Ipek; Ozgur, Mehtap; Kilic, Zeynel] Ankara Univ, Dept Chem, TR-06100 Ankara, Turkey; [Kayalak, Hande; Acik, Leyla] Gazi Univ, Dept Biol, TR-06500 Ankara, Turkey; [Turk, Mustafa] Kirikkale Univ, Dept Bioengn, TR-71450 Kirikkale, Turkey; [Hokelek, Tuncer] Hacettepe Univ, Dept Phys, TR-06800 Ankara, Turkey published Phosphorus-nitrogen compounds: Part 46. The reactions of N3P3Cl6 with bidentate and monodentate ligands: The syntheses, structural characterizations, antimicrobial and cytotoxic activities, and DNA interactions of (N/N)spirocyclotriphosphazenes with 4-chlorobenzyl pendant arm in 2019, Cited 59. Recommanded Product: 177-11-7. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

In the present study, the partly and fully-substituted monospiro (4-6, 4a-6d), cis-dispiro (7-9), trans-dispiro (10-15) cyclotriphosphazenes were synthesized for the investigations of their chemical, stereogenic and biological properties. The cis/trans phosphazenes (7-12) have two stereogenic P centers. They are expected to be in meso and racemic forms. In addition, the structures of four compounds were evaluated using X-ray crystal-lographic data. Compound 13 was found to be a single enantiomer (RR) in the solid state, as also proved with its CD spectrum. The antibacterial and antifungal activities of the phosphazenes were elucidated for against Gram-positive (G+) and Gram-negative (G-) bacteria, and yeast strains, respectively. Of the compounds, 14 exhibits strong antimicrobial activity against most of the tested organisms, especially B. cereus and E. hirae. MBC and MFC values of compounds on different bacterial and fungal species ranged from < 9.8 mu M to 2500 mu M. Furthermore, the cytotoxic activities of 6, 4c, 10 and 14 were investigated against L929 fibroblast and DLD-1 cells, and 14 was the most cytotoxic compound against DLD-1. Welcome to talk about 177-11-7, If you have any questions, you can contact Asmafiliz, N; Berberoglu, I; Ozgur, M; Kilic, Z; Kayalak, H; Acik, L; Turk, M; Hokelek, T or send Email.. Recommanded Product: 177-11-7

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Direct Catalytic Reductive N-Alkylation of Amines with Carboxylic Acids: Chemoselective Enannine Formation and further Functionalizations WOS:000480503700099 published article about TERTIARY AMIDES; HYDROGENATION; DERIVATIVES; AMINATION; NITRILES; HYDROSILANES; METHYLATION; AMIDATION; CHEMISTRY; MECHANISM in [Trillo, Paz; Adolfsson, Hans] Umea Univ, Dept Chem, KBC3,Linnaeus Vag 10, SE-90187 Umea, Sweden in 2019, Cited 66. COA of Formula: C7H13NO2. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

Direct reductive N-alkylation of secondary amines with carboxylic acids using molybdenum hexacarbonyl (5 mol %) as catalyst and diethoxymethylsilane as reducing agent generate enamines in a straightforward fashion in high yields. The formed enamines are without the need for isolation or purification further reacted with trimethylsilyl cyanide in the same reaction flask to yield alpha-amino nitriles in good yields. In the optimized reaction conditions equimolar amounts of carboxylic acid and amine are reacted under neat conditions, and a catalytic amount of trifluoroethanol (0.1 mol %) is added along with TMSCN for the cyanation step. The reductive N-alkylation reaction is demonstrated to be highly chemoselective, tolerating a multitude of different functional groups present in the starting carboxylic acids and amines. The reaction is scalable and the generated alpha-amino nitriles are converted to other useful compounds, e.g., alpha-amino acids or amino-tetrazoles. In addition, the intermediate enamines are further transformed into triazolines, sulfonylformamidines, pyrimidinediones, and TMS-propargylamines, respectively, in high yields under mild reaction conditions. Benzoic acids react with secondary amines under similar conditions to give tertiary amines in high yields, and using this methodology, the biologically active compound Piribedil was isolated in 80% yield in a direct one-pot reaction setup.

COA of Formula: C7H13NO2. Welcome to talk about 177-11-7, If you have any questions, you can contact Trillo, P; Adolfsson, H or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Alvarez, EM; Plutschack, MB; Berger, F; Ritter, T in [Alvarez, Eva Maria; Plutschack, Matthew B.; Berger, Florian; Ritter, Tobias] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany published Site-Selective C-H Functionalization-Sulfination Sequence to Access Aryl Sulfonamides in 2020, Cited 33. Computed Properties of C7H13NO2. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

Aryl sulfinates are precursors to a diverse number of sulfonyl-derived arenes, which are common motifs in pharmaceuticals and agrochemicals. Here, we report a site-selective two-step C-H sulfination sequence via aryl sulfonium salts to access aryl sulfonamides. Combined with site-selective aromatic thianthrenation, an operationally simple one-pot palladium-catalyzed protocol introduces the sulfonyl group using sodium hydroxymethylsulfinate (Rongalite) as a source of SO22-. The hydroxymethyl sulfone intermediate generated from the catalytic process can be employed as a synthetic handle to deliver a variety of sulfonyl-containing compounds.

Computed Properties of C7H13NO2. Bye, fridends, I hope you can learn more about C7H13NO2, If you have any questions, you can browse other blog as well. See you lster.

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Product Details of 177-11-7. I found the field of Chemistry very interesting. Saw the article Rhodium-Catalyzed Asymmetric Hydroamination of Allyl Amines published in 2019, Reprint Addresses Hull, KL (corresponding author), Univ Illinois, Dept Chem, 600 S Mathews, Urbana, IL 61801 USA.; Schultz, DM (corresponding author), Merck & Co Inc, Dept Proc Res & Dev, Rahway, NJ 07065 USA.; Hull, KL (corresponding author), Univ Texas Austin, 105 E 24th St, Austin, TX 78712 USA.. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane.

A Rh-catalyzed enantioselective hydroamination of allylamines using a chiral BIPHEP-type ligand is reported. Enantioenriched 1,2-diamines are formed in good yields and with excellent enantioselectivities. A diverse array of nucleophiles and amine directing groups are demonstrated, including deprotectable motifs. Finally, the methodology was demonstrated toward the rapid synthesis of 2-methyl-moclobemide.

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Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Recommanded Product: 1,4-Dioxa-8-azaspiro[4.5]decane. Recently I am researching about AGONIST SALVINORIN; PROLACTIN; DYNORPHIN; LY2456302; DOPAMINE; STRESS; 2-METHYL-N-((2′-(PYRROLIDIN-1-YLSULFONYL)BIPHENYL-4-YL)METHYL)PROPAN-1-AMINE; EXPRESSION; DISCOVERY; BINDING, Saw an article supported by the National Institute of Neurological Disorders and Stroke (NINDS) of the National Institutes of Health (NIH)United States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Institute of Neurological Disorders & Stroke (NINDS); BlackThorn Therapeutics; Blueprint Neurotherapeutics Network (BPN) of the NIH Blueprint for Neuroscience Research [1UH2 NS093030-01]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Guerrero, M; Urbano, M; Kim, EK; Gamo, AM; Riley, S; Abgaryan, L; Leaf, N; Van Orden, LJ; Brown, SJ; Xie, JY; Porreca, F; Cameron, MD; Rosen, H; Roberts, E. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

kappa opioid receptor (KOR) antagonists are potential pharmacotherapies for the treatment of migraine and stress-related mood disorders including depression, anxiety, and drug abuse, thus the development of novel KOR antagonists with an improved potency/selectivity profile and medication-like duration of action has attracted the interest of the medicinal chemistry community. In this paper, we describe the discovery of 1-(6-ethyl-8-fluoro-4-methyl-3-(3-methyl-1,2,4-oxadiazol-5-yl)quinolin-2-yl)-N-(tetrahydro-2 H-pyran-4-yl)piperidin-4 amine (CYM-53093, BTRX-335140) as a potent and selective KOR antagonist, endowed with favorable in vitro ADMET and in vivo pharmacokinetic profiles and medication-like duration of action in rat pharmacodynamic experiments. Orally administered CYM-53093 showed robust efficacy in antagonizing KOR agonist-induced prolactin secretion and in tail-flick analgesia in mice. CYM-53093 exhibited a broad selectivity over a panel of off-target proteins. This compound is in phase 1 clinical trials for the treatment of neuropsychiatric disorders wherein dynorphin is thought to contribute to the underlying pathophysiology.

Welcome to talk about 177-11-7, If you have any questions, you can contact Guerrero, M; Urbano, M; Kim, EK; Gamo, AM; Riley, S; Abgaryan, L; Leaf, N; Van Orden, LJ; Brown, SJ; Xie, JY; Porreca, F; Cameron, MD; Rosen, H; Roberts, E or send Email.. Recommanded Product: 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem