Category: 177-11-7

Leng, J; Tang, WJ; Fang, WY; Zhao, C; Qin, HL in [Leng, Jing; Fang, Wan-Yin; Zhao, Chuang; Qin, Hua-Li] Wuhan Univ Technol, State Key Lab Silicate Mat Architectures, Wuhan 430070, Peoples R China; [Leng, Jing; Fang, Wan-Yin; Zhao, Chuang; Qin, Hua-Li] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Wuhan 430070, Peoples R China; [Tang, Wenjian] Anhui Med Univ, Sch Pharm, Hefei 230032, Peoples R China published A Simple Protocol for the Stereoselective Construction of Enaminyl Sulfonyl Fluorides in 2020, Cited 52. COA of Formula: C7H13NO2. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

A clickable connective hub 1-bromo-2-triazole-thane-1-sulfonyl fluoride BTESF (1) was developed and successfully applied for the fluorosulfonylvinylation of a host of primary and secondary cyclic or acyclic amines including amino acids and pharmaceuticals. Further antimicrobial experiments revealed that vinyl sulfonyl fluoride functionalized norfloxacin (3ak), ciprofloxacin (3am), and lomefloxacin (3an) exhibited 4-fold improved antimicrobial activity against Gram-positive bacteria compared to their parent drugs.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article SYNTHESIS AND ANTITUBERCULAR EVALUATION OF FLUORINATED 2-CYCLOALKYLIMINO SUBSTITUTED 1,3-BENZOTHIAZIN-4-ONES WOS:000463978800010 published article about BENZOTHIAZINONE DERIVATIVES; TUBERCULOSIS; IDENTIFICATION in [Nosova, Emiliya V.; Batanova, Olga A.; Kotovskaya, Svetlana K.; Slepukhin, Pavel A.; Charushin, Valery N.] Ural Fed Univ, Dept Organ & Biomol Chem, 19 Mira st, Ekaterinburg 620002, Russia; [Nosova, Emiliya V.; Lipunova, Galina N.; Kotovskaya, Svetlana K.; Slepukhin, Pavel A.; Charushin, Valery N.] Russian Acad Sci, Postovsky Inst Organ Synth, Ural Branch, 22 S Kovalevskaya St,20 Akad Skaya St, Ekaterinburg 620137, Russia; [Kravchenko, Marionella A.] Ural Res Inst Phthisiopulmonol, 50 22 Partsezda St, Ekaterinburg 620039, Russia in 2019, Cited 22. Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

Novel fluorinated 2-substituted 1,3-benzothiazin-4-ones were obtained through the addition of N-nucleophiles to ortho-fluorobenzoylisothiocyanates, followed by cyclization of fluorobenzoyl-thioureas. Synthetic approaches to original 2-cycloalkylimino- and 2-carbonylpiperazino- substituted benzothiazinones, bearing different number of fluorine atoms in the benzene ring have been found. 2-Ethoxycarbonylpiperazino-5-fluoro-1,3-benzothiazin-4-one proved to exhibit a high tuberculostatic activity in vitro (MIC 0.7 microgram/mL), thus indicating that a search of biologically active compounds in this family of heterocycles appears to be a reasonable approach.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Diastereoselective synthesis of chiral 3-substituted isoindolinones via rhodium(iii)-catalyzed oxidative C-H olefination/annulation WOS:000661230200001 published article about N-ACYL KETIMINES; ASYMMETRIC-SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; 1,3-DISUBSTITUTED ISOINDOLINES; STEREOSELECTIVE-SYNTHESIS; CATALYZED ARYLATION; MICHAEL REACTIONS; DIRECTING GROUP; 3+2 ANNULATION; ACTIVATION in [Li, Xue-Hong; Gong, Jun-Fang; Song, Mao-Ping] Zhengzhou Univ, Green Catalysis Ctr, Coll Chem, Zhengzhou 450001, Peoples R China in 2021, Cited 104. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Product Details of 177-11-7

A new method for the direct and stereoselective synthesis of 3-substituted isoindolinones via Rh(iii)-catalyzed chiral N-sulfinyl amide directed asymmetric [4 + 1] annulation of benzamides with acrylic esters has been developed. The reaction proceeded through an oxidative C-H olefination and a subsequent cyclization by intramolecular aza-Michael addition, producing a series of diastereoisomeric chiral isoindolinones (20 examples) in generally good yields with a dr value up to 5.5 : 1. The absolute configurations of the newly formed C-stereocenters in the major and minor diastereomers of the catalysis product have been determined by X-ray crystal diffraction analysis to be S and R, respectively. The separation of the major diastereoisomers from the catalysis products and subsequent removal of the N-sulfinyl chiral auxiliary afforded enantiomerically pure (S)-isoindolinones. The application of the obtained (S)-isoindolinones in the synthesis of several biologically active isoindolinones such as (S)-PD172938, (S)-pazinaclone and (S)-pagoclone is presented.

Product Details of 177-11-7. Welcome to talk about 177-11-7, If you have any questions, you can contact Li, XH; Gong, JF; Song, MP or send Email.

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Piperidine – Wikipedia,
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I found the field of Chemistry very interesting. Saw the article DMAP and PivOH-promoted amination/allenization reaction published in 2020. Formula: C7H13NO2, Reprint Addresses Liang, YM (corresponding author), Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China.. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

This report described the first DMAP and PivOH-promotedortho-C-H amination andipso-allenization reaction of iodobenzenes realized by Pd/norbornene cooperative catalysis. Based on control experiments and DFT calculations, we speculated that the three ligands have different functions and mechanism paths in the reaction.

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Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane. In 2020 J ORG CHEM published article about SUBSTITUTED ARYL IODIDES; ARYLATIVE DEAROMATIZATION; FLUORESCENT-PROBE; ACCESS; LEVOFLOXACIN; BOND; PD; CYCLIZATION; AMINATION; AGENTS in [Zhang, Zhe; Zhang, Bo-Sheng; An, Yang; Liu, Ce; Gou, Xue-Ya; Liang, Yong-Min] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China; [Li, Kai-Li] Lanzhou Univ, Clin Med Coll 2, Lanzhou 730000, Peoples R China in 2020, Cited 103. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

This report describes a palladium-catalyzed dearomatization and amination tandem reaction of 2,3-disubstituted indoles and benzofurans via the Catellani strategy. This reaction provides a new method for the construction of amino-substituted indoline-fused cyclic and benzofuran spiro compounds in good yields. The reaction has broad functional group compatibility and substrate scope.

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Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

In 2020 ORG LETT published article about CATALYZED FLUOROSULFONYLVINYLATION; ARYLETHENESULFONYL FLUORIDES; ETHENESULFONYL FLUORIDE; LEAVING GROUPS; DUAL WARHEAD; HYDROAMINATION; INHIBITORS; CHEMISTRY; MACROLIDES; RESISTANCE in [Leng, Jing; Fang, Wan-Yin; Zhao, Chuang; Qin, Hua-Li] Wuhan Univ Technol, State Key Lab Silicate Mat Architectures, Wuhan 430070, Peoples R China; [Leng, Jing; Fang, Wan-Yin; Zhao, Chuang; Qin, Hua-Li] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Wuhan 430070, Peoples R China; [Tang, Wenjian] Anhui Med Univ, Sch Pharm, Hefei 230032, Peoples R China in 2020, Cited 52. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Category: piperidines

A clickable connective hub 1-bromo-2-triazole-thane-1-sulfonyl fluoride BTESF (1) was developed and successfully applied for the fluorosulfonylvinylation of a host of primary and secondary cyclic or acyclic amines including amino acids and pharmaceuticals. Further antimicrobial experiments revealed that vinyl sulfonyl fluoride functionalized norfloxacin (3ak), ciprofloxacin (3am), and lomefloxacin (3an) exhibited 4-fold improved antimicrobial activity against Gram-positive bacteria compared to their parent drugs.

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Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Palladium-Catalyzed C(sp(2))-N Bond Cross-Coupling with Triaryl Phosphates WOS:000468696400035 published article about BUCHWALD-HARTWIG AMINATION; C-N; ARYL CHLORIDES; REDUCTIVE AMINATION; ROOM-TEMPERATURE; AROMATIC AMINATION; ARYLATION; EFFICIENT; AMINES; MONOARYLATION in [Chen, Zicong; Chen, Xiangmeng; So, Chau Ming] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hung Hom, Kowloon, Hong Kong, Peoples R China; [So, Chau Ming] Hong Kong Polytech Univ, Shenzhen Res Inst, Shenzhen 518057, Peoples R China in 2019, Cited 81. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Recommanded Product: 177-11-7

The first general palladium-catalyzed amination of aryl phosphates is described. The combination of MorDalPhos with [Pd(pi-cinnamyl)Cl](2) enables the amination of electron-rich, electron-neutral, and electron-poor aryl phosphates with a board range of aromatic, aliphatic, and heterocyclic amines. Common functional groups such as ether, keto, ester, and nitrile show an excellent compatibility in this reaction condition. The solvent-free amination reactions are also successful in both solid coupling partners. The gram-scale cross-coupling is achieved by this catalytic system.

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Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Electrochemical Iodoamination of Indoles Using Unactivated Amines WOS:000598141000008 published article about C-H FUNCTIONALIZATION; PHOTOCATALYTIC OXIDATION; REGIOSELECTIVE AMINATION; IMIDYL RADICALS; IODINE; ELECTROSYNTHESIS; GENERATION; AMIDATION; CHEMISTRY; ARENES in [Lei, Ning; Shen, Yanling; Li, Yujun; Tao, Pan; Yang, Liquan; Su, Zhishan; Zheng, Ke] Sichuan Univ, Coll Chem, Key Lab Green Chem & Technol, Minist Educ, Chengdu 610064, Peoples R China in 2020, Cited 72. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Computed Properties of C7H13NO2

An environmentally friendly electrochemical approach for iodoamination of various indole derivatives with a series of unactivated amines, amino acid derivatives, and benzotriazoles (more than 80 examples) has been developed. This strategy was further applied in late-stage functionalization of natural products and pharmaceuticals and gram-scale synthesis and radiosynthesis of I-13(1)-labeled compounds. Fundamental insights into the mechanism of the reaction based on control experiments, density functional theory calculation, and cyclic voltammetry are provided.

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Piperidine – Wikipedia,
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Recently I am researching about TERTIARY AMIDES; HYDROGENATION; DERIVATIVES; AMINATION; NITRILES; HYDROSILANES; METHYLATION; AMIDATION; CHEMISTRY; MECHANISM, Saw an article supported by the Swedish Research CouncilSwedish Research CouncilEuropean Commission [2016-05316]; Umea University. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Trillo, P; Adolfsson, H. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane. Category: piperidines

Direct reductive N-alkylation of secondary amines with carboxylic acids using molybdenum hexacarbonyl (5 mol %) as catalyst and diethoxymethylsilane as reducing agent generate enamines in a straightforward fashion in high yields. The formed enamines are without the need for isolation or purification further reacted with trimethylsilyl cyanide in the same reaction flask to yield alpha-amino nitriles in good yields. In the optimized reaction conditions equimolar amounts of carboxylic acid and amine are reacted under neat conditions, and a catalytic amount of trifluoroethanol (0.1 mol %) is added along with TMSCN for the cyanation step. The reductive N-alkylation reaction is demonstrated to be highly chemoselective, tolerating a multitude of different functional groups present in the starting carboxylic acids and amines. The reaction is scalable and the generated alpha-amino nitriles are converted to other useful compounds, e.g., alpha-amino acids or amino-tetrazoles. In addition, the intermediate enamines are further transformed into triazolines, sulfonylformamidines, pyrimidinediones, and TMS-propargylamines, respectively, in high yields under mild reaction conditions. Benzoic acids react with secondary amines under similar conditions to give tertiary amines in high yields, and using this methodology, the biologically active compound Piribedil was isolated in 80% yield in a direct one-pot reaction setup.

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Piperidine – Wikipedia,
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Category: piperidines. In 2019 ORG LETT published article about CYANOGEN-BROMIDE; N-CYANATION; ELECTROPHILIC CYANATION; TIEMANN REARRANGEMENT; PRACTICAL SYNTHESIS; BACE1 INHIBITOR; VERUBECESTAT; AMINATION in [Kuhl, Nadine; Raval, Saurin; Cohen, Ryan D.] Merck & Co Inc, Dept Proc Res & Dev, Rahway, NJ 07065 USA in 2019, Cited 46. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

An operationally simple oxidation cyanation method for the synthesis of cyanamides is described. The procedure utilizes inexpensive and commercially available N-chlorosuccinimide and Zn(CN)(2) as reagents to avoid direct handling of toxic cyanogen halides. It is demonstrated to be amenable for the cyanation of a variety of primary and secondary amines and aniline derivatives as well as a complex synthetic intermediate en route to verubecestat (MK-8931). Additionally, kinetic measurements and other control experiments are reported to shed light onto the mechanism of this cyanation reaction.

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Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem