Top Picks: new discover of 1-Benzyl-3,3-dimethylpiperidin-4-one

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A novel series of mGluR2 positive allosteric modulators (PAMs), 1-[(1-methyl-1H-imidazol-2-yl)methyl]-4-phenylpiperidines, is herein disclosed. Structure-activity relationship studies led to potent, selective mGluR2 PAMs with excellent pharmacokinetic profiles. A representative lead compound (+)-17e demonstrated dose-dependent inhibition of methamphetamine-induced hyperactivity and mescaline-induced scratching in mice, providing support for potential efficacy in treating psychosis.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H17628N – PubChem

 

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Lithiated benzothiophenes and benzofurans require 2-silyl protection to avoid anion migration

2-Trimethylsilyl protection of benzothiophenes and benzofurans prevents anion migration to the 2-position when lithiated species are formed. These lithiated benzothiophenes and benzofurans provide superior results in additions to piperidones. Deprotection is conveniently achieved under acidic conditions. Direct C-7 metalation of benzothiophene is enabled by 2-triisopropylsilyl protection at C-2.

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Piperidine – Wikipedia,
Piperidine | C5H17630N – PubChem

 

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PIPERIDINE DERIVATIVES AS SEROTONINE REUPTAKE INHIBITORS

The present invention provides compounds of formula I and a method of inhibiting the reuptake of serotonin, antagonizing the 5-HT 1A receptor and antagonizing the 5-HT 2A receptor which comprises administering to a subject in need of such treatment an effective amount of a compound of formula I.

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Piperidine – Wikipedia,
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PIPERIDINE DERIVATIVES HAVING EFFECTS ON SEROTONIN RELATED SYSTEMS

The present invention provides the compounds of the following formula:Wherein the variables are as defined in the specification and a method for inhibiting the reuptake of seretonin, antagonizing the 5-HT 1A receptor and antagonizing the 5-HT 2A receptor which comprises administering to a subject in need of such treatment an effective amount of the compound of above formula.

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Reference£º
Piperidine – Wikipedia,
Piperidine | C5H17607N – PubChem

 

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CHEMOKINE RECEPTOR ANTAGONISTS AND METHODS OF USE THEREFOR

Disclosed are novel compounds and a method of treating a disease associated with aberrant leukocyte recruitment and/or activation. The method comprises administering to a subject in need an effective amount of a compound represented by: or physiologically acceptable salt thereof.

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Piperidine – Wikipedia,
Piperidine | C5H17623N – PubChem

 

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Preparation of substituted piperidin-4-ones

The present invention provides a novel process for the preparation of substituted piperidine-4-ones useful as intermediates in the preparation of pharmaceuticals.

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Piperidine – Wikipedia,
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SEROTONERGIC BENZOTHIOPHENES

The present invention provides serotonergic benzothiophenes of Formula (I), where A, R, R1, R2, R3, and R4 are as described in the specification.

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Piperidine – Wikipedia,
Piperidine | C5H17608N – PubChem

 

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The synthetic route of 173186-91-9 has been constantly updated, and we look forward to future research findings.

173186-91-9, 1-Benzyl-3,3-dimethylpiperidin-4-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation 11 4-Methylamino-3,3-dimethylpiperidine Potassium hydroxide (12.85 g, 230 mmol) was added to the stirred solution of methylamine hydrochloride (15.5 g, 230.0 mmol) in methanol (100 ml) and stirring was continued for 30 min at 30 C. 1-Benzyl-3,3-dimethyl-4-piperidone (5 g, 23.0 mmol), was added to the resulting mixture and stirred for 6 hr. Sodium cyanoborohydride (1.45 g, 23.0 mmol) was added to it and reaction mixture was stirred for 15 hr. The reaction mixture was concentrated to dryness, triturated with water, extracted with chloroform, dried (Na2SO4) and concentrated to give 1-benzyl-4-methylamino-3,3-dimethylpiperidine. Yield 5.3 g (99%), C15H24N2, m/z 233 (M+1), PMR (CDCl3): 0.9 (s, 3H), 1.0 (s, 3H), 1.38 (m, 2H), 1.54 (bs, 1H, D2O exchangeable), 1.68-2.1 (m, 4H), 2.4 (s, 3H), 2.86 (m, 1H), 3.4 (dd, 2H), 7.3 (m, 5H)., 173186-91-9

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Reference£º
Patent; Wockhardt Limited; US6878713; (2005); B2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem