Category: 1722-95-8

Anet, Frank A. L. et al. published their research in Journal of the American Chemical Society in 1989 | CAS: 1722-95-8

(R)-2-Methylpiperidine (cas: 1722-95-8) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Application In Synthesis of (R)-2-Methylpiperidine

Stereogenic (chiral) methyl groups: determination of configuration by direct tritium NMR spectroscopy was written by Anet, Frank A. L.;O’Leary, Daniel J.;Beale, John M.;Floss, Heinz G.. And the article was included in Journal of the American Chemical Society in 1989.Application In Synthesis of (R)-2-Methylpiperidine This article mentions the following:

The configuration of CHDTX, where X is a leaving group, can be determined by direct tritium NMR of the product obtained by methylation of resolved 2-methylpiperidine with CHDTX and this provides a new and highly accurate determination of enantiomeric purity in CHDTX. The two diastereomers of [7-2H1,3H]-1,2-dimethylpiperidine differ in chem. shifts by 4.4 Hz (0.014 ppm), with the tritium more shielded in the (2R,7S) than in the (2S,7S) diastereomer, in agreement with predictions based on the proton NMR of the racemate of 1,2-dimethylpiperidine monodeuterated on the N-Me group. In the experiment, the researchers used many compounds, for example, (R)-2-Methylpiperidine (cas: 1722-95-8Application In Synthesis of (R)-2-Methylpiperidine).

(R)-2-Methylpiperidine (cas: 1722-95-8) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Application In Synthesis of (R)-2-Methylpiperidine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Pugniere, Martine et al. published their research in Journal of Chromatography A in 1997 | CAS: 1722-95-8

(R)-2-Methylpiperidine (cas: 1722-95-8) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Piperidine derivatives bearing a masked aldehyde function in the 蔚-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Reference of 1722-95-8

Adsorption liquid chromatography on silica for the chiral separation of amino acids and asymmetric amines derivatized with optically active N-伪-9-fluorenylmethyloxycarbonyl-amino acid-N-carboxyanhydrides was written by Pugniere, Martine;Mattras, Helene;Castro, Bertrand;Previero, Aldo. And the article was included in Journal of Chromatography A in 1997.Reference of 1722-95-8 This article mentions the following:

Optically pure N-伪-Fmoc-amino acid-N-carboxyanhydrides (Fmoc-AA-NCAs, Fmoc = 9-fluorenylmethyloxycarbonyl) are proposed as precolumn reagents for the chiral anal. of asym. amines, including 伪-amino acid alkyl esters. Separation of diastereomers arising from racemic amines was better achieved by liquid-solid adsorption chromatog. on silica than by reversed-phase techniques. Sample preparation is easily performed, and the properties of the Fmoc group allows high sensitivity by fluorescent detection. In this mode, picomolar limits of enantiomeric excess were detected. In the experiment, the researchers used many compounds, for example, (R)-2-Methylpiperidine (cas: 1722-95-8Reference of 1722-95-8).

(R)-2-Methylpiperidine (cas: 1722-95-8) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Piperidine derivatives bearing a masked aldehyde function in the 蔚-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Reference of 1722-95-8

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Berthod, A. et al. published their research in Chromatographia in 2001 | CAS: 1722-95-8

(R)-2-Methylpiperidine (cas: 1722-95-8) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Product Details of 1722-95-8

Ionic liquids as stationary phase solvents for methylated cyclodextrins in gas chromatography was written by Berthod, A.;He, L.;Armstrong, D. W.. And the article was included in Chromatographia in 2001.Product Details of 1722-95-8 This article mentions the following:

Room temperature ionic liquids (RTIL) are molten salts with m.ps. well below room temperature 1-Butyl-3-methylimidazolium chloride is a typical example of such RTIL. It was used as a solvent to dissolve permethylated-尾-cyclodextrin (BPM) and dimethylated-尾-cyclodextrin (BDM) to prepare stationary phases for capillary columns in gas chromatog. for chiral separation The RTIL containing columns were compared to com. columns containing the same chiral selectors. A set of 64 chiral compounds separated by the com. BPM column was tested on the RTIL BPM column. Only 21 were enantioresolved. Similarly, a set of 80 compounds separated by the com. BDM column was passed on the RTIL BDM column with only 16 pos. separations Probably the imidazolium ion pair could make an inclusion complex with the cyclodextrin cavity, blocking it for chiral recognition. All the chiral compounds recognized by the RTIL columns had their asym. carbon that was part of a ring structure. The retention factors of the derivatized solutes were lower on the RTIL columns than those obtained on the com. equivalent column. The peak efficiencies obtained with the RTIL capillary were significantly higher than that obtained with the com. column. These observations may contribute to the knowledge of the mechanism of cyclodextrin-based GC enantioselective separations In the experiment, the researchers used many compounds, for example, (R)-2-Methylpiperidine (cas: 1722-95-8Product Details of 1722-95-8).

(R)-2-Methylpiperidine (cas: 1722-95-8) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Product Details of 1722-95-8

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Tanaka, Hiroaki et al. published their research in Bioorganic & Medicinal Chemistry in 2020 | CAS: 1722-95-8

(R)-2-Methylpiperidine (cas: 1722-95-8) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N鈥揌 bond in an axial position, and the other in an equatorial position.Related Products of 1722-95-8

Discovery and structure-activity relationships study of positive allosteric modulators of the M3 muscarinic acetylcholine receptor was written by Tanaka, Hiroaki;Negoro, Kenji;Koike, Takanori;Tsukamoto, Issei;Yokoyama, Kazuhiro;Maeda, Jun;Inagaki, Yusuke;Shimoshige, Yukinori;Ino, Katsutoshi;Ishizu, Kenichiro;Takahashi, Taisuke. And the article was included in Bioorganic & Medicinal Chemistry in 2020.Related Products of 1722-95-8 This article mentions the following:

The M3 muscarinic acetylcholine receptor (mAChR) is a member of the family of mAChRs, which are associated with a variety of physiol. functions including the contraction of various smooth muscle tissues, stimulation of glandular secretion, and regulation of a range of cholinergic processes in the central nerve system. We report here the discovery and a comprehensive structure-activity relationships (SARs) study of novel pos. allosteric modulators (PAMs) of the M3 mAChR through a high throughput screening (HTS) campaign. Compound 9(I) exhibited potent in vitro PAM activity towards the M3 mAChR and significant enhancement of muscle contraction in a concentration-dependent manner when applied to isolated smooth muscle strips of rat bladder. Compound 9 also showed excellent subtype selectivity over other subtypes of mAChRs including M1, M2, and M4 mAChRs, and moderate selectivity over the M5 mAChR, indicating that compound 9 is an M3-preferring M3/M5 dual PAM. Moreover, compound 9 displayed acceptable pharmacokinetics profiles after oral dosing to rats. These results suggest that compound 9 may be a promising chem. probe for the M3 mAChR for further investigation of its pharmacol. function both in vitro and in vivo. In the experiment, the researchers used many compounds, for example, (R)-2-Methylpiperidine (cas: 1722-95-8Related Products of 1722-95-8).

(R)-2-Methylpiperidine (cas: 1722-95-8) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N鈥揌 bond in an axial position, and the other in an equatorial position.Related Products of 1722-95-8

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Allen, Scott E. et al. published their research in Journal of the American Chemical Society in 2014 | CAS: 1722-95-8

(R)-2-Methylpiperidine (cas: 1722-95-8) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising α-glucosidase inhibitors. The former are analogs of DNJ with an improved α-glucosidase inhibitory profile than that of DNJ. Boisson et al.Recommanded Product: 1722-95-8

Concerted Amidation of Activated Esters: Reaction Path and Origins of Selectivity in the Kinetic Resolution of Cyclic Amines via N-Heterocyclic Carbenes and Hydroxamic Acid Cocatalyzed Acyl Transfer was written by Allen, Scott E.;Hsieh, Sheng-Ying;Gutierrez, Osvaldo;Bode, Jeffrey W.;Kozlowski, Marisa C.. And the article was included in Journal of the American Chemical Society in 2014.Recommanded Product: 1722-95-8 This article mentions the following:

The N-heterocyclic carbene and hydroxamic acid cocatalyzed kinetic resolution of cyclic amines generates enantioenriched amines and amides with selectivity factors up to 127. In this report, a quantum mech. study of the reaction mechanism indicates that the selectivity-determining aminolysis step occurs via a novel concerted pathway in which the hydroxamic acid plays a key role in directing proton transfer from the incoming amine. This modality was found to be general in amide bond formation from a number of activated esters including those generated from HOBt and HOAt, reagents that are broadly used in peptide coupling. For the kinetic resolution, the proposed model accurately predicts the faster reacting enantiomer. A breakdown of the steric and electronic control elements shows that a gearing effect in the transition state is responsible for the observed selectivity. In the experiment, the researchers used many compounds, for example, (R)-2-Methylpiperidine (cas: 1722-95-8Recommanded Product: 1722-95-8).

(R)-2-Methylpiperidine (cas: 1722-95-8) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising α-glucosidase inhibitors. The former are analogs of DNJ with an improved α-glucosidase inhibitory profile than that of DNJ. Boisson et al.Recommanded Product: 1722-95-8

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

29-Sep-2021 News New explortion of 1722-95-8

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Formula: C6H13N, you can also check out more blogs about1722-95-8

Chemistry is traditionally divided into organic and inorganic chemistry. Formula: C6H13N. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 1722-95-8

Compounds of general formula (I) in which:A represents a hydrogen atom, a hydroxyl, a C1-3 alkoxy group, a hydroxy(C1-6 alkyl) group, a (C1-3 alkoxy)(C1-3 alkyl) group, a thiol, (C1-6 alkyl)sulfanyl or a halogen;B and D represent, independently of one another, a hydrogen atom, a C1-6 alkyl group, a fluoro(C1-6 alkyl) group or a perfluoro(C1-2 alkyl) group or B and D together from an oxo;R1 represents a phenyl, a naphthyl or a heteroaryl comprising 4 or 5 carbon atoms;R2 and R3 represent, independently of one another, a hydrogen atom, a halogen or a C1-6 alkyl group,R4 represents a hydrogen atom, a hydroxyl or a halogen, andR5 and R6 represent, independently of one another, a hydrogen atom, a C1-6 alkyl group, a C2-6 alkenyl group, a C3-6 cycloalkyl group, a C3-6 cycloalkenyl group, a fluoro(C1-6 alkyl) group or a perfluoro(C1-2 alkyl) group or R5 and R6 together form a C2-6 alkylene chain or a C3-6 alkenylene chain, to give, with the nitrogen to which they are attached, a heterocycle, this heterocycle optionally being substituted by a C1-4 alkyl group; and their salts.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Formula: C6H13N, you can also check out more blogs about1722-95-8

Reference：
Piperidine – Wikipedia,
Piperidine | C5H507N – PubChem

 

Brief introduction of 1722-95-8

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Synthetic Route of 1722-95-8, you can also check out more blogs about1722-95-8

Synthetic Route of 1722-95-8, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 1722-95-8, Name is (R)-2-Methylpiperidine, molecular formula is C6H13N. In a Article，once mentioned of 1722-95-8

Proteasomes of pathogenic microbes have become attractive targets for anti-infectives. Coevolving with its human host, Mycobacterium tuberculosis (Mtb) has developed mechanisms to resist host-imposed nitrosative and oxidative stresses. Genetic deletion or pharmacological inhibition of the Mtb proteasome (Mtb20S) renders nonreplicating Mtb susceptible to reactive nitrogen species in vitro and unable to survive in the lungs of mice, validating the Mtb proteasome as a promising target for anti-Mtb agents. Using a structure-guided and flow chemistry-enabled study of structure-activity relationships, we developed phenylimidazole-based peptidomimetics that are highly potent for Mtb20S. X-ray structures of selected compounds with Mtb20S shed light on their selectivity for mycobacterial over human proteasomes.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H492N – PubChem

 

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One of the oldest and most widely used commercial enzyme inhibitors is aspirin, SDS of cas: 1722-95-8, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 1722-95-8

Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 1722-95-8, molcular formula is C6H13N, introducing its new discovery. SDS of cas: 1722-95-8

The presence of an N-N chiral axis in a 3-(N-benzoyl-N- isobutanoyl)aminoquinazolin-4(3H)-one (DAQ) bearing a chiral substituent in the 2-position of the quinazolinone allows separation of two enantiopure diastereoisomers; one of these diastereoisomers reacts with racemic 2- methylpiperidine to give (R)(+)-1-benzoyl-2-methylpiperidine (95% ee) and (S)-2-methylpiperidine (91% ee) even using stoichiometric quantities of reagents (1 equiv. DAQ: 2 equiv. amine). (C) 2000 Elsevier Science Ltd.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H481N – PubChem

 

Brief introduction of (R)-2-Methylpiperidine

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 1722-95-8, and how the biochemistry of the body works.Application of 1722-95-8

Application of 1722-95-8, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.1722-95-8, Name is (R)-2-Methylpiperidine, molecular formula is C6H13N. In a article，once mentioned of 1722-95-8

A series of 2-aryl tryptamines have been identified as high-affinity h5-HT(2A) antagonists. Structure-activity relationship studies have shown that h5-HT(2A) affinity can be attained via modifications to the tryptamine side chain and that selectivity over h5-HT(2C) and hD2 receptors can be controlled by suitable C-2 aryl groups. (C) 2000 Elsevier Science Ltd.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H515N – PubChem

 

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Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Synthetic Route of 1722-95-8, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 1722-95-8, in my other articles.

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This letter describes the synthesis and structure activity relationship (SAR) studies of structurally novel M4 antagonists, based on a 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazine core, identified from a high-throughput screening campaign. A multi-dimensional optimization effort enhanced potency at human M4 (hM4 IC50s < 200 nM), with only moderate species differences noted, and with enantioselective inhibition. Moreover, CNS penetration proved attractive for this series (rat brain:plasma Kp = 2.1, Kp,uu = 1.1). Despite the absence of the prototypical mAChR antagonist basic or quaternary amine moiety, this series displayed pan-muscarinic antagonist activity across M1-5 (with 9- to 16-fold functional selectivity at best). This series further expands the chemical diversity of mAChR antagonists. Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Synthetic Route of 1722-95-8, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 1722-95-8, in my other articles.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H469N – PubChem