Category: 1722-11-8

Synthetic Route of 1722-11-8, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.1722-11-8, Name is 3-Chloro-6-(piperidin-1-yl)pyridazine, molecular formula is C9H12ClN3. In a article，once mentioned of 1722-11-8

A series of 2-substituted-6-(morpholinyl/piperidinyl)pyridazin-3(2H)-ones was synthesized and the structures were established using various spectroscopic techniques. The target compounds were screened for anti-inflammatory and analgesic activities at 20 and 40 mg/kg. The safety of the synthesized derivatives was evaluated by assessing anti-platelet activity and ulcer index. The obtained pharmacological data revealed that 6-morpholinyl derivatives 4a?12a were found to be somewhat more potent than 6-piperidinyl derivatives 4b?6b. The 6-morpholinyl substituted pyridazinone 12a exhibited maximum anti-inflammatory and analgesic activities. Homoveratrylamine substituted compounds 6a and 6b emerged as promising leads in both the series with good anti-inflammatory and analgesic activities without any ulcerogenicity. Anti-platelet activity results of the compounds of both the series showed significantly low bleeding time in comparison with standard drug aspirin indicating the cardiovascular safety of new pyridazinones.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H13166N – PubChem

 

Application of 1722-11-8, In heterogeneous catalysis, the catalyst is in a different phase from the reactants. At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 1722-11-8, name is 3-Chloro-6-(piperidin-1-yl)pyridazine. In an article£¬Which mentioned a new discovery about 1722-11-8

Structure-activity relationship studies of SEN12333 analogues: Determination of the optimal requirements for binding affinities at alpha7 nAChRs through incorporation of known structural motifs

Alpha7 nicotinic acetylcholine receptors (nAChRs) have implications in the regulation of cognitive processes such as memory and attention and have been identified as a promising therapeutic target for the treatment of the cognitive deficits associated with schizophrenia and Alzheimer’s disease (AD). Structure affinity relationship studies of the previously described alpha7 agonist SEN12333 (8), have resulted in the identification of compound 45, a potent and selective agonist of the alpha7 nAChR with enhanced affinity and improved physicochemical properties over the parent compound (SEN12333, 8).

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.1722-11-8. In my other articles, you can also check out more blogs about 1722-11-8

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H13165N – PubChem