With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.170921-48-9,8-Benzyl-1,3,8-triazaspiro[4.5]decan-4-one,as a common compound, the synthetic route is as follows.
Example 73 (racscis)-8-(2-Hydroxy-2-phenyl-cyclohexy1)-1-(3-methyl-butyl)-1, 3, 8-triaza- spiro [4.5] decan-4-one; a) 8-Benzyl-1- (3-methyl-butyl)-1, 3, 8-triaza-spiro [4. 5 decan-4-one; To a solution of 100 mg (0.408 mmol) 8-benzyl-1, 3,8-triaza-spiro [4, 5] decan-4-one (m. p. 164-166 C) and 0.062 ml (49.2 mg, 0.571 mmol) isovaleraldehyde in 3 ml 1,2- dichloroethane were added 130 mg (0.611 mmol) sodium triacetoxyborohydride and the mixture stirred at ambient temperature for 16 h. Then the reaction mixture was quenched with 10 ml saturated aqueous NaHC03-solution and extracted with dichloromethane. The organic extracts were washed with brine, dried over Na2SOj, filtered and evaporated: 128 mg 8-benzyl-1- (3-methyl-butyl)-1, 3,8-triaza- spiro [4. 5] decan-4-one as colourless crystals : m. p. 139-140 C, MS (ISP): 316.4 MH+., 170921-48-9
As the paragraph descriping shows that 170921-48-9 is playing an increasingly important role.
Reference：
Patent; F.HOFFMANN-LA ROCHE AG; WO2005/40166; (2005); A1;,
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