Category: 170364-89-3

Wang, Zemin published the artcileDearomatization-Rearomatization Strategy for Reductive Cross-Coupling of Indoles with Ketones in Water, Application In Synthesis of 170364-89-3, the publication is Organic Letters (2019), 21(7), 2302-2306, database is CAplus and MEDLINE.

N-Alkylation of indoles is one of the important pathways for the construction of various biol. active indole mols. Using ketones as N-alkylation reagent for indoles was a great challenge not only because of the competing alkylation reaction of C-3 position but also because of the poor nucleophilicity of the nitrogen atom of indole, in addition to the steric hindrance and lower electrophilicity of the ketones. A dearomatization-rearomatization strategy was developed for reductive cross-coupling of indoles with ketones in water. Various functional groups and other heterocyclic compounds are tolerated.

Organic Letters published new progress about 170364-89-3. 170364-89-3 belongs to piperidines, auxiliary class Indole,Piperidine,Amide, name is tert-Butyl 4-(1H-indol-1-yl)piperidine-1-carboxylate, and the molecular formula is C18H10, Application In Synthesis of 170364-89-3.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem

Liu, Jian-Guo published the artcileDevelopment of Bisindole-Substituted Aminopyrazoles as Novel GSK-3β Inhibitors with Suppressive Effects against Microglial Inflammation and Oxidative Neurotoxicity, Formula: C18H24N2O2, the publication is ACS Chemical Neuroscience (2020), 11(20), 3398-3408, database is CAplus and MEDLINE.

Development of glycogen synthase kinase-3β (GSK-3β) inactivation-centric agents with polypharmacol. profiles is increasingly recognized as a promising therapeutic strategy against the multifactorial etiopathol. of Alzheimer’s disease (AD). In this respect, a series of disubstituted aminopyrazole derivatives were designed and synthesized as a new class of GSK-3β inhibitors. Most of these derivatives possess GSK-3β inhibitory activities with IC₅₀ values in the micromolar ranges, among which bisindole-substituted aminopyrazole derivative 6h displayed moderate GSK-3β inhibition (IC₅₀ = 1.76 ± 0.19μM), and alleviative effects against lipopolysaccharide (LPS)-induced glial inflammation in BV-2 cells and glutamate-induced oxidative neurotoxicity in HT-22 cells. Further in vivo studies indicated that compound 6h(I) had potent anti-inflammatory effect, by showing markedly reduced microglial activation and astrocyte proliferation in the brain of LPS-injected mice. Overall, the simultaneous modulation of 6h on multiple dysfunctions of disease network highlights this structural distinctively bisindole-substituted aminopyrazole could be a useful prototype for the discovery of novel therapeutic agents to tackle AD and other GSK-3β associated complex neurol. syndromes.

ACS Chemical Neuroscience published new progress about 170364-89-3. 170364-89-3 belongs to piperidines, auxiliary class Indole,Piperidine,Amide, name is tert-Butyl 4-(1H-indol-1-yl)piperidine-1-carboxylate, and the molecular formula is C18H24N2O2, Formula: C18H24N2O2.

Referemce:
https://en.wikipedia.org/wiki/Piperidine,
Piperidine | C5H11N – PubChem