Category: 168466-84-0

Reference of 168466-84-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.168466-84-0, Name is (R)-3-Amino-1-benzylpiperidine, molecular formula is C12H18N2. In a Article，once mentioned of 168466-84-0

A therapeutic rationale is proposed for the treatment of inflammatory diseases, such as rheumatoid arthritis (RA), by specific targeting of the JAK1 pathway. Examination of the preferred binding conformation of clinically effective, pan-JAK inhibitor 1 led to identification of a novel, tricyclic hinge binding scaffold 3. Exploration of SAR through a series of cycloamino and cycloalkylamino analogues demonstrated this template to be highly tolerant of substitution, with a predisposition to moderate selectivity for the JAK1 isoform over JAK2. This study culminated in the identification of subnanomolar JAK1 inhibitors such as 22 and 49, having excellent cell potency, good rat pharmacokinetic characteristics, and excellent kinase selectivity. Determination of the binding modes of the series in JAK1 and JAK2 by X-ray crystallography supported the design of analogues to enhance affinity and selectivity.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H12575N – PubChem

Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 168466-84-0, molcular formula is C12H18N2, introducing its new discovery. Computed Properties of C12H18N2

The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the histamine-3 receptor.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H12565N – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， Product Details of 168466-84-0, Which mentioned a new discovery about 168466-84-0

Janus kinase 1 selective inhibitors and pharmaceutical use thereof are provided.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H12570N – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, name: (R)-3-Amino-1-benzylpiperidine, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 168466-84-0, Name is (R)-3-Amino-1-benzylpiperidine, molecular formula is C12H18N2. In a Patent, authors is ，once mentioned of 168466-84-0

The invention provides novel compounds of formula I having the general formula (I) wherein X, R 1 , R 2 , R 3 and R 5 are as described herein. Accordingly, the compounds may be provided in pharmaceutically acceptable compositions and used for the treatment of immunological or hyperproliferative disorders

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about is helpful to your research. name: (R)-3-Amino-1-benzylpiperidine

Reference：
Piperidine – Wikipedia,
Piperidine | C5H12568N – PubChem