Category: 163271-08-7

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.163271-08-7,tert-Butyl (4-methylpiperidin-4-yl)carbamate,as a common compound, the synthetic route is as follows.

To a solution of 3-(benzyloxy)-5-bromo-2-(2,3-dichlorophenyl)pyrazine (90.0 mg, 220 muetaiotaomicron, 1 equiv) in toluene (1 mL) was added ter/-butyl(4-methylpiperidin-4-yl)carbamate (70.5 mg, 329 muiotaetaomicron, 1.5 equiv), NaOt-Bu (42.2 mg, 439 muiotaetaomicron, 2 equiv), [l-(2- diphenylphosphanyl-l-naphthyl)-2-naphthyl]-diphenyl-phosphane (137 mg, 219 muiotaetaomicron, 1 equiv) and Pd2(dba)3 (10.0 mg, 11.0 mumol, 0.05 equiv). The reaction mixture was then warmed to 90 C and stirred for 1 hour. The reaction mixture was then filtered and concentrated under reduced pressure. The residue was purified by silica gel chromatography to give fer/-butyl(l-(6- (benzyloxy)-5-(2,3-dichlorophenyl)pyrazin-2-yl)-4-methylpiperidin-4-yl)carbamate (100 mg, 184 mupiiotaomicron, 83.8% yield) as a white solid.

163271-08-7, 163271-08-7 tert-Butyl (4-methylpiperidin-4-yl)carbamate 19691370, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; REVOLUTION MEDICINES, INC.; JOGALEKAR, Ash; WON, Walter; KOLTUN, Elena S.; GILL, Adrian; MELLEM, Kevin; AAY, Naing; BUCKL, Andreas; SEMKO, Christopher; KISS, Gert; (496 pag.)WO2018/13597; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

163271-08-7, tert-Butyl (4-methylpiperidin-4-yl)carbamate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A flask was charged with triphosgene (12.2 g, 41.1 mmol, 1.50 equiv), DCM (50 mL), l, l, l,3,3,3-hexafluoropropan-2-ol (20.6 g, 122 mmol, 4.50 equiv). N,N-diisopropylethylamine (17.6 g, 136 mmol, 5.00 equiv) was added dropwise at 0 C. The resulting solution was stirred for 2 h at 0 C. t-Butyl N-(4-methylpiperidin-4-yl)carbamate (5.84 g, 27.2 mmol, 1.00 equiv) was added. The resulting solution was stirred for 2 h at 0 C and quenched with water (100 mL), as described in Example 6, Step 4. The residue was chromatographed on a silica gel column to provide 4.90 g (44% yield) of l, l, l,3,3,3-hexafluoropropan-2-yl 4-((t-butoxycarbonyl)amino)-4- methylpiperidine-l-carboxylate as a yellow oil. LCMS (ESI, m/z): 409 [M+H]+.

163271-08-7, As the paragraph descriping shows that 163271-08-7 is playing an increasingly important role.

Reference£º
Patent; ABIDE THERAPEUTICS, INC.; GRICE, Cheryl A.; WEBER, Olivia D.; BUZARD, Daniel J.; SHAGHAFI, Michael B.; JONES, Todd K.; (275 pag.)WO2019/46318; (2019); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

163271-08-7, tert-Butyl (4-methylpiperidin-4-yl)carbamate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 5-bromo-2-(2,3-dichlorophenyl)sulfanyl-3-[(4- methoxyphenyl)methoxy]pyrazine (1.40 g, 2.96 mmol, 1.00 equiv) and tert-butyl N-(4-methyl-4- piperidyl)carbamate (824.66 mg, 3.85 mmol, 1.30 equiv) in toluene (10.00 mL) was added NaOt-Bu (568.91 mg, 5.92 mmol, 2.00 equiv), BINAP (184.3 mg, 0.296.00 mmol, 0.10 equiv) and Pd2(dba)3 (135.53 mg, 0.148 mmol, 0.05 equiv) at 20 C. The mixture was stirred at 130 C by microwave heating for 3 hours under N2. The residue was purified by column chromatography to give tert-butyl N-[l-[5-(2, 3-dichlorophenyl) sulfanyl-6-[(4-methoxyphenyl) methoxy] pyrazin-2-yl]-4-methyl-4-piperidyl] carbamate (500 mg, 0.825 mmol, 27%) as a yellow oil., 163271-08-7

163271-08-7 tert-Butyl (4-methylpiperidin-4-yl)carbamate 19691370, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; REVOLUTION MEDICINES, INC.; JOGALEKAR, Ash; WON, Walter; KOLTUN, Elena S.; GILL, Adrian; MELLEM, Kevin; AAY, Naing; BUCKL, Andreas; SEMKO, Christopher; KISS, Gert; (496 pag.)WO2018/13597; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

163271-08-7, tert-Butyl (4-methylpiperidin-4-yl)carbamate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 6-chloro-3-(2,3-dichlorophenyl)pyrazine-2-carbonitrile (50 mg, 176 mupiiotaomicron, 1 equiv) and ter/-butyl(4-methylpiperidin-4-yl)carbamate (56.5 mg, 264 mupiiotaomicron, 1.5 equiv) in dioxane (1 mL) and DIPEA (1 mL) was warmed to 120 C and stirred for 2 hours. The mixture was then concentrated under reduced pressure to give ter/-butyl(l-(6-cyano-5-(2,3- dichlorophenyl)pyrazin-2-yl)-4-methylpiperidin-4-yl)carbamate (80 mg, crude) as a yellow oil which was used directly in the next step without further purification. LC-MS (ESI): m/z: [M + H] calculated for C22H25C12N502: 462.14; found 462.0., 163271-08-7

The synthetic route of 163271-08-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; REVOLUTION MEDICINES, INC.; JOGALEKAR, Ash; WON, Walter; KOLTUN, Elena S.; GILL, Adrian; MELLEM, Kevin; AAY, Naing; BUCKL, Andreas; SEMKO, Christopher; KISS, Gert; (496 pag.)WO2018/13597; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.163271-08-7,tert-Butyl (4-methylpiperidin-4-yl)carbamate,as a common compound, the synthetic route is as follows.

Ethyl 3-chloro-6-(2,3-dichlorophenyl)-5-methoxypyrazine-2-carboxylate (158 mg, 0.44 mmol, 1 equiv), tert-butyl(4-methylpeperidin-4-yl)carbamate (141 mg, 0.7 mmol, 1.5 equiv) and DIPEA (0.15 mL, 0.9 mmol, 2 equiv) were dissolved in DMF (3.16 mL) in glass sealed reactor. The reaction mixture was stirred at 85 C overnight. After cooling to room temperature, water was added and product was purified via column chromatography (Si02, 0- 20%) ethyl acetate in hexane) to afford ethyl 3-{4-[(tert-butoxycarbonyl)amino]-4- methylpiperidin-l-yl}-6-(2,3-dichlorophenyl)-5-methoxypyrazine-2-carboxylate (210 mg, 89%). 1H NMR (400 MHz, DMSO-i) delta 7.70 (dd, J = 6.9, 2.7 Hz, 1H), 7.48 – 7.40 (m, 2H), 6.65 (s 1H), 4.27 (q, J= 7.0 Hz, 2H), 3.88 (s 3H), 3.61 (m, 2H), 2.14 (m, 2H), 1.57 – 1.48 (m, 2H), 1.41 (s, 9H), 1.32 – 1.25 (m, 6H), 163271-08-7

As the paragraph descriping shows that 163271-08-7 is playing an increasingly important role.

Reference£º
Patent; REVOLUTION MEDICINES, INC.; JOGALEKAR, Ash; WON, Walter; KOLTUN, Elena S.; GILL, Adrian; MELLEM, Kevin; AAY, Naing; BUCKL, Andreas; SEMKO, Christopher; KISS, Gert; (496 pag.)WO2018/13597; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.163271-08-7,tert-Butyl (4-methylpiperidin-4-yl)carbamate,as a common compound, the synthetic route is as follows.,163271-08-7

Preparation of tert-butyl (l-(5-(3-cvano-6-hydroxypyrazolorL5-a1pyridin- 4-yl)pyridin-2-yl)-4-methylpiperidin-4-yl)carbamate. To a solution of 4-(6-fluoropyridin-3- yl)-6-hydroxypyrazolo[l,5-a]pyridine-3-carbonitrile (Intermediate P66; 3.0 g, 9.44 mmol) and tert-butyl 4-methylpiperidin-4-ylcarbamate (2.83 mg, 13.2 mmol) in DMSO (12 mL) was added DIEA (4.93 mL, 28.3 mmol). The reaction was stirred 16 h at 90C. After cooling to ambient temperature, the reaction mixture was diluted into water and acidified to pH 5 using a 10% citric acid solution and stirred for 15 min at ambient temperature. The suspension was filtered and the precipitate was rinsed with water. The isolated solids were dissolved in 4: 1 DCM:IPA and dried over anhydrous Na2S04(S), filtered and concentrated in vacuo. The residue was purified using silica chromatography (5-75% EtOAc in DCM) to afford the title compound (assumed theoretical yield, 4.23 g) in sufficient purity for step 2. MS (apci) m/z= 449.3 (M+H)

The synthetic route of 163271-08-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ANDREWS, Steven W.; ARONOW, Sean; BLAKE, James F.; BRANDHUBER, Barbara J.; COLLIER, James; COOK, Adam; HAAS, Julia; JIANG, Yutong; KOLAKOWSKI, Gabrielle R.; MCFADDIN, Elizabeth A.; MCKENNEY, Megan L.; MCNULTY, Oren T.; METCALF, Andrew T.; MORENO, David A.; RAMANN, Ginelle A.; TANG, Tony P.; REN, Li; WALLS, Shane M.; (946 pag.)WO2018/71454; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

163271-08-7, tert-Butyl (4-methylpiperidin-4-yl)carbamate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Methanesulfonyl chloride (0.18 ml_) was added to a solution of 3-[2-(3-{[tert- butyl(dimethyl)silyl]oxy}-2,2-dimethylpropyl)-4-(1 -hydroxyethyl)-1 -oxo-1 ,2- dihydroisoquinolin-6-yl]-Lambda/-cyclopropyl-5-fluoro-4-methylbenzamide (Example 41a, 1.1 g) and triethylamine (0.66 ml_) in DCM (9 ml_) at 0 0C. The solution (total volume 11 mL) was stirred for 10 min and then 1 h at room temperature to afford a stock solution (11 mL). Aliquots of this were used directly without further purification to prepare examples 41 – 45.A solution of terf-butyl (4-methylpiperidin-4-yl)carbamate (74 mg) in DCM (1 mL) was added to a 1 mL aliquot of the above stock solution and the reaction stirred for 20 h. 4 M HCI in dioxane (1 mL) was added and the reaction allowed to stir for a further 20 h. The volatiles were removed in vacuo and the crude material was dissolved in methanol (2 mL) and loaded onto a 10 g SCX cartridge. The impurities were washed through with methanol (75 mL) and discarded. The product was eluted with 1 N methanolic ammonia (75 mL) and evaporated in vacuo. Purification by preparative HPLC (Gemini-NX C18 column using a 95-5 % gradient of aqueous 0.1 % ammonia in methanol as eluent) afforded the title product (10 mg) as a solid. MS: APCI(+ve) 563 (M+H)+ 1H NMR delta (DMSO-Cl6) 8.52 (d, 1H)1 8.36 (d, 1H), 8.17 (s, 1H), 7.68 – 7.64 (m, 2H), 7.53 (dd, 1 H), 7.34 (s, 1H), 4.89 (t, 1H), 4.10 (s, 1 H), 3.94 (dd, 2H), 3.84 (q, 1 H), 3.32 (s, 4H), 3.17 (s, 1 H), 3.11 (d, 2H), 2.85 (sextet, 1H), 2.60 – 2.32 (m, 4H), 2.23 (d, 3H), 1.33 (d, 3H), s 0.98 (s, 3H), 0.87 (s, 6H), 0.69 (td, 2H), 0.58 – 0.54 (m, 2H)

163271-08-7, As the paragraph descriping shows that 163271-08-7 is playing an increasingly important role.

Reference£º
Patent; ASTRAZENECA AB; BROUGH, Stephen, John; LUKER, Timothy, Jon; ROBERTS, Bryan, Glyn; ST-GALLAY, Stephen, Anthony; WO2010/39079; (2010); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem