Category: 161609-84-3

Properties and Exciting Facts About 161609-84-3

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 161609-84-3

Related Products of 161609-84-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.161609-84-3, Name is Benzyl 4-cyanopiperidine-1-carboxylate, molecular formula is C14H16N2O2. In a Patent，once mentioned of 161609-84-3

A thiazolidine derivative represented by the formula (I) wherein each symbol is as defined in the specification, and a pharmaceutically acceptable salt thereof exhibit a potent DPP-IV inhibitory activity, and can be provided as an agent for the prophylaxis or treatment of diabetes, an agent for the prophylaxis or treatment of obesity and the like.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 161609-84-3

Reference：
Piperidine – Wikipedia,
Piperidine | C5H20333N – PubChem

 

New explortion of 161609-84-3

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Computed Properties of C14H16N2O2, you can also check out more blogs about161609-84-3

Chemistry is traditionally divided into organic and inorganic chemistry. Computed Properties of C14H16N2O2. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 161609-84-3

The addition of alpha-deprotonated nitriles to azaheteroA-cycles followed by rearomatization is described. A simple two-step, one-pot procedure for the sequence is also presented. Georg Thieme Verlag Stuttgart New York.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Computed Properties of C14H16N2O2, you can also check out more blogs about161609-84-3

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H20330N – PubChem

 

Brief introduction of 161609-84-3

161609-84-3, 161609-84-3 Benzyl 4-cyanopiperidine-1-carboxylate 22028286, apiperidines compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.161609-84-3,Benzyl 4-cyanopiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

(3) The above-mentioned compound (1.42 g) was dissolved in N-methyl-2-pyrrolidone (60 mL), and sodium azide (1.13 g) and triethylamine hydrochloride (1.24 g) were added thereto. The mixture was stirred at 150C for 6 hr. 1 mol/L Hydrochloric acid was added to the reaction mixture to adjust its pH to 1, and the mixture was extracted with ethyl acetate. 10% Aqueous sodium hydroxide solution was added to the extract, and the mixture was washed with diethyl ether. The aqueous layer was adjusted to pH 1 with concentrated hydrochloric acid, and the mixture was extracted with ethyl acetate. The extract was dried and concentrated under reduced pressure. Trifluoroacetic acid (6 mL), tert-butanol (0.900 g) and concentrated sulfuric acid (0.16 mL) were added to the residue, and the mixture was stirred at room temperature for 3 days. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was washed successively with 2.5 mol/L aqueous sodium hydroxide solution and brine, dried, and concentrated under reduced pressure. The residue was purified by HPLC to give 1-benzyloxycarbonyl-4-(2-tert-butyl-2H-tetrazol-5-yl)piperidine (140 mg) as a white solid.

161609-84-3, 161609-84-3 Benzyl 4-cyanopiperidine-1-carboxylate 22028286, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; WELFIDE CORPORATION; EP1308439; (2003); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

Brief introduction of 161609-84-3

161609-84-3 Benzyl 4-cyanopiperidine-1-carboxylate 22028286, apiperidines compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.161609-84-3,Benzyl 4-cyanopiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

General procedure AF: Alkylation a to a nitrileA base such as LiHMDS, NaHMDS, KHMDS, LDA, NaH (1 to 5 equiv, preferably 1.5 equiv) is added to a nitrile compound in a suitable organic solvent such as THF, 1,4-dioxane, Et20, hexane, DMF, DMA (preferably THF) at about -78 C to rt (preferably about -78 C to 0 C) and stirred for 0.5 to 2 h (preferably about 1 h). An alkylating agent (1 to 5 equiv, preferably 1.5 equiv) is added and the mixture stirred for 30 min to 24 h (preferably about 16 h). To the mixture is is added an aqueous salt solution (preferably saturated NH4C1) and the mixture is extracted with a suitable organic solvent such as EtOAc, DCM, Et20 (preferably DCM). The organic layer is isolated and may be optionally washed in no particular order with water and/or aqueous solutions containing an acid (such as HC1, AcOH or NH4C1) and/or aqueous solutions containing a base (such as NaHC03, Na2C03, NaOH, KOH or NH4OH) and/or aqueous solutions containing an inorganic salt (such as NaCl Na2S03 or Na2S2C>3). The organic solution may then be optionally dried with a drying agent (such as anhydrous MgS04 or Na2S0 ), filtered and concentrated in vacuo to give the targeted compound. Alternatively, the residue obtained by concentration of the organic extracts may be purified by HPLC or column chromatography to provide the target compound.Illustration of General Procedure AF:Preparation No.AF.l: Benz l 4-cyano-4-methylpiperidine-l-carboxylateLiHMDS (47.6 mL, 47.6 mmol) was added dropwise via syringe to the mixture of benzyl 4- cyanopiperidine-l-carboxylate (8.00 g, 31.8 mmol, [Oakwood]) in THF (50 mL) at about -78 C and stirred for about 1 h. Mel (6.76 g, 47.6 mmol) was added dropwise via syringe at about -78 C and the mixture was stirred overnight at rt. The solution was cooled to 0 C and saturated aqueous NH4C1 (200 mL) was added. The mixture was extracted with DCM (3×300 mL). The combined organic extracts were dried over anhydrous Na2S04, filtered and concentrated in vacuo. The sample was deposited onto silica gel and purified by column chromatography eluting with 10: 1 pet ether/EtOAc to give benzyl 4-cyano-4-methylpiperidine-l-carboxylate (6.6 g, 74%): LC/MS (Table 2, Method i) Rt = 2.03 min; MS m/z: 259 (M+H)+.

161609-84-3 Benzyl 4-cyanopiperidine-1-carboxylate 22028286, apiperidines compound, is more and more widely used in various.

Reference£º
Patent; ABBOTT LABORATORIES; CALDERWOOD, David, J.; WILSON, Noel, S.; COX, Philip; HOEMANN, Michael, Z.; CLAPHAM, Bruce; MULLEN, Kelly, D.; VASUDEVAN, Anil; VILLAMIL, Clara I; LI, Bin; SOMAL, Gagandeep; WO2012/48222; (2012); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem