Category: 161491-24-3

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.161491-24-3,1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate,as a common compound, the synthetic route is as follows.

In a reaction flask, methyl N-Boc-3-methylcarboxylate-4-pyridinone 25g (0.1mol) was added to methanol 300mL, then add ammonium acetate 22g (0.3mol), the reaction overnight, TLC monitoring The reaction of raw materials was complete, spin the methanol, add water 900mL, the reaction mixture was extracted three times with 300mL of dichloromethane, the combined organic phase was dried over anhydrous sodium sulfate, and dried to give a red oily liquid N-Boc-3-carboxylic acid methyl ester Amino-3-ene-piperidine 22g, 161491-24-3

161491-24-3 1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate 11276893, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Wang Huiqin; (16 pag.)CN107151247; (2017); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.161491-24-3,1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate,as a common compound, the synthetic route is as follows.

161491-24-3, A solution of O1-tert-butyl O3-methyl 4-oxopiperidine-1,3-dicarboxylate (1 g, 3.88 mmol) in DMF (100 mL) was cooled to 0¡ã C. followed by portion wise addition of NaH (60percent dispersion of mineral oil, 0.16 g, 3.88 mmol). The resulting mixture was stirred at the same temperature for 15 min followed by addition of MeI (0.7 mL, 11.64 mmol) at 0¡ã C. then stirred at rt for 44 h. After completion of reaction (by TLC), water (100 mL) was added and extracted with EtOAc (3.x.100 mL). The combined organics were washed with brine, dried (Na2SO4), filtered and concentrated under reduced pressure to obtain the product as a yellow oil (0.9 g). MS: 272.12 [M+H]+.

As the paragraph descriping shows that 161491-24-3 is playing an increasingly important role.

Reference£º
Patent; BIOTA EUROPE LTD.; US2012/88750; (2012); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

161491-24-3, 1-tert-Butyl 3-methyl 4-oxopiperidine-1,3-dicarboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In the reaction flask,N-Boc-3-carboxylate-4-piperidone 25 g (0.1 mol)Added to methanol 300mL,Ammonium acetate 22g (0.3 mol) was further added,Reaction overnight,TLC monitoring raw material reaction is complete, dry methanol, add water 900mL,The reaction mixture was extracted with 300 mL of dichloromethane three times,The combined organic phases were dried over anhydrous sodium sulfate,Dried to get a red oily liquidN-Boc-3- carboxylateAmino-3-ene-piperidine 25g

161491-24-3, As the paragraph descriping shows that 161491-24-3 is playing an increasingly important role.

Reference£º
Patent; Mao Jiajing; (22 pag.)CN107286160; (2017); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem