Category: 159874-38-1

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.159874-38-1,Benzyl 4-(ethylamino)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

Method B; Preparation of ter/-butyl 4-{2-[ethyl(piperidin-4-yl)amino]-2-oxoethyl}piperazine-l- carboxylate.; Step 1: Preparation of tert-buty 4-{2-[{l-[(benzyloxy)carbonyl]piperidin-4-yl}(ethyl)amino]-2-oxoethyl}piperazine-l-carboxylate.; Diisopropylethylamine (1.3 ml) was added to a slurry of [4-(tert- butoxycarbonyl)piperazin-l-yl]acetic acid dihydrate (1.12g) [154478-71-6] in dichloromethane (16 ml) followed by HATU (1.82g) and the mixture was stirred under argon for 30 minutes. A solution of benzyl 4-(ethylarnino)piperidine-l-carboxylate (1.05g) [159874-38-1] in dichloromethane (4 ml) was added and the mixture was stirred for 24 hours, then diluted with dichloromethane (25 ml), washed consecutively with 2M NaOH (2×20 ml) and brine (1×20 ml) and dried. The solvent was evaporated and the residue was purified on a 4Og silica column eluted with a solvent gradient made up of ethyl acetate to 5% methanol: ethyl acetate. The yellow oil obtained was used directly in the next stage, LC-MS M+H 489 plus a HATU derived impurity M+H 175.1H NMR (CDCl3): 1.12 (3H, m), 1.44 (9H, s), 1.54-1.74 (8H, m), 2.48 (4H, d), 3.19-3.38 (4H, m), 3.44 (4H, d), 4.30 (IH, m), 5.14 (2H, s). 7.36 (5H, s)., 159874-38-1

159874-38-1 Benzyl 4-(ethylamino)piperidine-1-carboxylate 23369962, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2006/67385; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

159874-38-1, Benzyl 4-(ethylamino)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1-Benzyloxycarbonyl-4-(N-ethylformamido)piperidine. A stirred solution of 1-benzyloxycarbonyl-4-(N-ethylamino)piperidine (1.5 g) in triethyl orthoformate (10 mL) containing a catalytic amount of p-toluenesulfonic acid was heated at 90 C. for 12 hours. The reaction mixture was diluted with 1.0 N hydrochloric acid (10 mL), stirred for 30 minutes, diluted with water, and extracted with dichloromethane. The organic extracts were washed (aqueous sodium bicarbonate, water), dried, and evaporated to an oil that slowly solidified. The solid was suspended in ether and filtered to give the formamido compound (1.0 g) as a white solid; MS: m/z=291(M+1); NMR: ca. 1.5:1 mixture of rotamers, 8.15 (s,0.6), 8.11 (s,0.4), 7.36 (m,5), 5.14 (m,2), 4.30 (m,2.4), 3.43 (m,0.6), 3.25 (m,2), 2.82 (m,2), 1.73 (m,4), 1.21 (t,1.2, J=7.2), 1.15 (t,1.8, J=7.1).

159874-38-1, As the paragraph descriping shows that 159874-38-1 is playing an increasingly important role.

Reference£º
Patent; Zeneca Limited; US5576333; (1996); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem