Category: 15883-20-2

Synthetic Route of 15883-20-2, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 15883-20-2, Name is N-(2′,6′-Dimethylphenyl)-2-piperidinecarboxamide, molecular formula is C14H20N2O. In a Article£¬once mentioned of 15883-20-2

Synthesis, biological evaluation, and molecular docking of ropivacaine analogs as local anesthetic agents

Two series of ropivacaine analogs (4a?4q, 7a?7c) were synthesized, and their biological activities were evaluated as local anesthetic agents. Most of the compounds displayed detectable local anesthetic characteristics. Among them, compound 4l showed significant efficacy with sciatic nerve block, infiltration, corneal surface, and spinal anesthetic activities. It was as potent as the reference compound ropivacaine. Dissociation constants of these compounds were 5.9?7.9. In addition, molecular docking modeling on compound 4l and ropivacaine was performed to delineate structural requirements and potential mechanisms for the local anesthetic activity. This study provides valuable new information for our ongoing endeavor to design more potent local anesthetics.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Synthetic Route of 15883-20-2, you can also check out more blogs about15883-20-2

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H18786N – PubChem

 

Application of 15883-20-2, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 15883-20-2, Name is N-(2′,6′-Dimethylphenyl)-2-piperidinecarboxamide, molecular formula is C14H20N2O. In a Article£¬once mentioned of 15883-20-2

Synthesis, biological evaluation, and molecular docking of ropivacaine analogs as local anesthetic agents

Two series of ropivacaine analogs (4a?4q, 7a?7c) were synthesized, and their biological activities were evaluated as local anesthetic agents. Most of the compounds displayed detectable local anesthetic characteristics. Among them, compound 4l showed significant efficacy with sciatic nerve block, infiltration, corneal surface, and spinal anesthetic activities. It was as potent as the reference compound ropivacaine. Dissociation constants of these compounds were 5.9?7.9. In addition, molecular docking modeling on compound 4l and ropivacaine was performed to delineate structural requirements and potential mechanisms for the local anesthetic activity. This study provides valuable new information for our ongoing endeavor to design more potent local anesthetics.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Application of 15883-20-2, you can also check out more blogs about15883-20-2

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H18786N – PubChem

 

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 15883-20-2, name is N-(2′,6′-Dimethylphenyl)-2-piperidinecarboxamide, introducing its new discovery. HPLC of Formula: C14H20N2O

Substituted piperidine amide derivatives and their pharmaceutically acceptable preparation method and in the application of the (by machine translation)

The invention relates to a compound of general formula (I) said substituted piperidine amide derivatives or a stereoisomer thereof, a pharmaceutically acceptable salt, and its preparation method, the drug combination of the local anesthesia or analgesia in and to the use of, the general formula (I) each group definition consistent with the specification; (by machine translation)

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 15883-20-2 is helpful to your research. HPLC of Formula: C14H20N2O

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H18794N – PubChem

 

15883-20-2, N-(2′,6′-Dimethylphenyl)-2-piperidinecarboxamide is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 7 A clean and dry four neck round bottom flask was charged with N-((R)-1- phenylethyl)phthalamic acid (28.9 gm), isopropanol (300 ml) and 2′,6′-pipecoloxylidide (25 gm). The reaction mixture was stirred at 25C to 30C for one hour. The reaction mass was cooled to 1 0C to 15C to get a precipitate of corresponding (R)-(-)- 2′, 6′- pipecoloxylidide-phthalamic acid salt (27.30 gm) which was separated by filtration to afford white crystalline solid. IR:- 3300.8, 3032.8, 1677.2, 1629.7, 1583.4, 1529.8, 1444.7, 1378.4, 1244.8, 1037.7, 947.9, 835.5, 699.9 CM”1 NMR:- delta = 1.39(d, J= 4.0Hz, 3H), 1.50-1.70(m, 4H), 2.13(s, 7H), 2.82(dd, J= 2.8Hz, 5.8Hz, 16.4Hz, 1H), 3.13(d, J = 12.4Hz, 1H), 3.79(dd, J = 2.8Hz, 2.8Hz, 1 1.0Hz, 1H), 5.06(pen, 1H), 7.04-7.10(m, 3H), 7.21(t, J= 7.2Hz, 7.2Hz, 1H), 7.3 l(t, J= 7.6Hz, 7.6Hz, 2H), 7.30-7.43(m, 4H), 7.57(d, J= 6.4Hz, 2H), 9.68(s, 1H), 10.27(s, 1H). The filtrate was concentrated under vacuum, treated with 10%) sodium carbonate (500 ml) and stirred the reaction mass at room temperature for 1.5 hours to get a solid. The solid was collected by filtration, washed with water and dried to get (S)-2′,6′-pipecoloxylidide. Yield – 12 gm (96%) Enantiomeric purity – 96.66% (R)-(-)-2′,6′-pipecoloxylidide-phthalamic acid salt was hydro lyzed with 10% sodium carbonate (520 ml) and stirred the reaction mass at room temperature for one hour to get a solid. The solid washed with water and dried to get (R)-2′,6′-pipecoloxylidide. Yield – 9.3 gm (74.4%) Enantiomeric purity – 95.95%

15883-20-2, As the paragraph descriping shows that 15883-20-2 is playing an increasingly important role.

Reference£º
Patent; NEON LABORATORIES LIMITED; DALVI, Mahesh Bhagoji; KENNY, Rajesh Shashikant; TARADE, Pradeep Kisan; WO2014/9964; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.15883-20-2,N-(2′,6′-Dimethylphenyl)-2-piperidinecarboxamide,as a common compound, the synthetic route is as follows.

To 1L four reaction flask was added 500g of toluene, then add 100g of starting material,Then add 1.01 ~ 1.05 equivalent of anhydrous potassium carbonate, then add 2% to 6% tetrabutylammonium bromide,Then add 1.1 to 1.3 times the equivalent of n-butyl bromide, and slowly warmed to 80 ~ 85 , incubated for 5 hours,Cooled to room temperature, filtered, the filtrate was transferred to a 1L four-necked flask,Hydrogen chloride gas is passed into the filtrate until it is no longer absorbed, filtered, the filter cake washed with toluene,Dried to give bupivacaine hydrochloride 132.84 ~ 141.70g,HPLC content> 99%, yield 90% ~ 96%., 15883-20-2

The synthetic route of 15883-20-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Jiangsu Tianhe Pharmaceutical Co., Ltd.; Wang Lei; Liu Lei; Zhao Yunde; Wang Zhiquan; Zhu Linfei; (9 pag.)CN106117118; (2016); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem