With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.153749-89-4,tert-Butyl 2-cyanopiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.
Example 9.1; 2-(2H-Tetrazol-5-yl)-piperidine-1-carboxylic acid tert-butyl ester; 2-Cyano-piperidine-1-carboxylic acid tert-butyl ester (2.1 g, 10 mmol) was mixed with sodium azide (0.715 g, 11 mmol) and ammonium chloride (0.588 g, 11 mmol) in N,N-dimethylformamide (7.5 mL). The reaction mixture was heated at 100 C. for overnight. The reaction mixture was cooled to room temperature and diluted with water. The product was extracted using ethyl acetate. The organic phase was dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The crude yellow oil gave a white solid after trituration with ethyl acetate, as the title product (1.23 g, 48.6%).1H NMR (300 MHz, CDCl3): delta 5.63 (br, 1H), 4.02 (m, 1H), 2.76 (td, 1H), 2.43 (m, 1H), 1.96 (m, 2H), 1.8 (m, 2H), 1.55 (m, 2H), 1.49 (s, 9H)., 153749-89-4
As the paragraph descriping shows that 153749-89-4 is playing an increasingly important role.
Reference£º
Patent; AstraZeneca AB; NPS PHARMACEUTICALS, INC.; US2007/259916; (2007); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem