Category: 153439-40-8

Insights into urticaria in pediatric and adult populations and its management with fexofenadine hydrochloride was written by Ansotegui, Ignacio J.;Bernstein, Jonathan A.;Canonica, Giorgio W.;Gonzalez-Diaz, Sandra N.;Martin, Bryan L.;Morais-Almeida, Mario;Murrieta-Aguttes, Margarita;Sanchez Borges, Mario. And the article was included in Allergy, Asthma, & Clinical Immunology in 2022.Product Details of 153439-40-8 This article mentions the following:

The present narrative review provides a comprehensive update of the current knowledge on urticaria, both in adult and pediatric populations, and on the safety and efficacy of fexofenadine hydrochloride (HCl) as a treatment option. A literature search was conducted on Embase and Medline. Clin. studies published in English and published between 1999 and 2020 were selected. Although the exact pathogenesis of urticaria is not fully understood, multiple pathways of mast cell activation are discussed to explain the existence of phenotypically different clin. manifestations of urticaria. An overview of the worldwide prevalence of chronic urticaria, including disease burden and patient’s quality of life is provided. The impact of urticaria on patient’s life differs on the basis of whether its form is acute or chronic, but pharmacol. approaches are most often needed to control the disabling symptoms. A summary of the current management of urticaria recommended by different guidelines across countries (Global; European; American; Australian; Asian; Japanese) is presented. Non-sedating, second-generation H₁-antihistamines are the preferred choice of treatment across several guidelines worldwide. Herein, the efficacy and safety of fexofenadine HCl, a representative second-generation H₁-antihistamine approved for the treatment of urticaria, is discussed. The occurrence of urticaria manifestations in COVID-19 patients is also briefly presented. The burden of acute and chronic urticaria is high for patients. Second generation anti-histamines such as fexofenadine HCl can help managing the symptoms. In the experiment, the researchers used many compounds, for example, 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride (cas: 153439-40-8Product Details of 153439-40-8).

2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride (cas: 153439-40-8) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Product Details of 153439-40-8

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

UV spectrophotometric derivative methods for estimation of fexofenadine hydrochloride in bulk drug and pharmaceutical dosage form was written by Rele, Rajan V.. And the article was included in Journal of Chemical and Pharmaceutical Research in 2016.HPLC of Formula: 153439-40-8 This article mentions the following:

Simple and precise UV spectrophotometric methods by second and third order derivative have been developed and validated for the estimation of fexofenadine hydrochloride in bulk and its tablet formulation. The standard and sample solutions of fexofenadine hydrochloride were prepared in 0.1 N Hydrochloric acid. Fexofenadine hydrochloride was estimated at 215 nm for the second order derivative and 233.7 nm for third order derivative resp. Beer’s law was obeyed in the concentration range of 1 to 14 渭g / ml with coefficient of correlation values were 0.9992 for second order derivative method and 0.9997 for third order derivative method resp. These methods were tested and validated for various parameters according to ICH guidelines. The precision expressed as relative standard deviation were of 0.8908 % and 1.152% for the above two methods resp. The proposed methods were successfully applied for the determination of fexofenadine hydrochloride in pharmaceutical formulation. Results of the anal. were validated statistically and were found to be satisfactory. The proposed methods are simple, easy to apply, low-cost and require relatively inexpensive instruments. In the experiment, the researchers used many compounds, for example, 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride (cas: 153439-40-8HPLC of Formula: 153439-40-8).

2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride (cas: 153439-40-8) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.HPLC of Formula: 153439-40-8

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Design and development of oral thin film of antihistaminic drug fexofenidine was written by Shrivas, Astha;Jain, Ashish;Yadav, Pradeep Kumar;Singhai, Akhlesh Kumar. And the article was included in World Journal of Pharmaceutical Research in 2022.Recommanded Product: 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride This article mentions the following:

Bioadhesive formulations have a wide scope of applications, for both systemic and local effects. The mucosa is relatively permeable with a rich blood supply. The oral transmucosal drug delivery bypasses first pass effect and avoids pre-systemic elimination in the GI tract. These factors make the oral mucosa a very attractive and feasible site for systemic drug delivery. A few drugs have been successfully administered via buccal route. The buccal region offers an attractive route of administration for systemic drug delivery. Fexofenadine, H1 antagonist, is a potent antihistamine. Buccal absorption studies of fexofenadine having partition coefficient less than 2 and have lipophilicity in nature, which offers advantages of buccal route over oral route. By observing the above points, it is inferred that fexofenadine has a need to formulate into buccal patches and the drug is suitable for it. Bioadhesive formulations have a wide scope of applications, for both systemic and local effect for management of diseases. Fexofenadine drug will be use for developing a dosage form for a very quick onset of action, which is beneficial in managing severe conditions of allergies, aiding in the enhancement of bioavailability, and is very convenient for administration, without the problem of swallowing and using water. In the present study, Fexofenadine HCl was used as a model drug candidate and nine fast-dissolving films formulations containing different polymer concentrations were prepared Fast-dissolving films of Fexofenadine HCl were prepared by the solvent casting method on glass molds, using HPMC E15 and Xanthan gum, Sodium starch glycolate as disintegrating agent, glycerin as plasticizer and aspartame as sweetener and distilled water as a solvent. The effect of the nature of polymers was studied by preparing various formulations of oral dispersible films. The various formulations containing a combination of polymers, release was found to be in the following order: OTF7 > OTF8 > OTF9 and formulations OTF7, OTF1, and OTF4 were found to be the best formulations in terms of drug release. The results of the release kinetics study showed that all the formulations obeyed first order drug release profile more closely, i.e., the release rate depended upon the initial concentration of drug. The slope values of the Korsmeyer-Peppas plot showed that the mechanism was non-fickian or supercase II transport mechanism. In the experiment, the researchers used many compounds, for example, 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride (cas: 153439-40-8Recommanded Product: 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride).

2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride (cas: 153439-40-8) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Recommanded Product: 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Development of analytical method and its validation in bilayer tablet containing fexofenadine hydrochloride (immediate release layer) and montelukast sodium (sustained release layer) was written by Thakur, Sourav;Singh, Bhupendra;Vyas, Manish;Saini, Geetanjali;Yadav, Ravi Shankar;Khatik, Gopal;Chaudhary, Amit;Sharma, Neha. And the article was included in Asian Journal of Pharmaceutics in 2019.COA of Formula: C32H40ClNO4 This article mentions the following:

Aim: The aim of the present study was to develop and validate the anal. method for bilayer tablets. Materials and Methods: Simultaneous estimation of fexofenadine hydrochloride (HCl) and montelukast sodium in bilayer tablets by UV spectrophotometric method. Results and Discussion: The absorption maxima of fexofenadine HCl and montelukast sodium were found to be 259 nm and 285 nm, resp., using phosphate buffer pH 6.8. The method obeys Beer’s law in the concentration range of 24-84渭g/mL and 2-14渭g/mL for fexofenadine HCl and montelukast sodium, resp. Different anal. parameters such as limit of detection, limit of quantitation, accuracy, and precision were determined as per International Council for Harmonisation guidelines Q2 (R1). Conclusion: The accuracy of the method was found to be 99.71% and 99.13% for fexofenadine HCl and montelukast sodium, resp. There is no interference shown by the excipients of the formulation in the method and the method can be used for routine quality control. In the experiment, the researchers used many compounds, for example, 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride (cas: 153439-40-8COA of Formula: C32H40ClNO4).

2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride (cas: 153439-40-8) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.COA of Formula: C32H40ClNO4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Development of analytical method and its validation in bilayer tablet containing fexofenadine hydrochloride (immediate release layer) and montelukast sodium (sustained release layer) was written by Thakur, Sourav;Singh, Bhupendra;Vyas, Manish;Saini, Geetanjali;Yadav, Ravi Shankar;Khatik, Gopal;Chaudhary, Amit;Sharma, Neha. And the article was included in Asian Journal of Pharmaceutics in 2019.COA of Formula: C32H40ClNO4 This article mentions the following:

Aim: The aim of the present study was to develop and validate the anal. method for bilayer tablets. Materials and Methods: Simultaneous estimation of fexofenadine hydrochloride (HCl) and montelukast sodium in bilayer tablets by UV spectrophotometric method. Results and Discussion: The absorption maxima of fexofenadine HCl and montelukast sodium were found to be 259 nm and 285 nm, resp., using phosphate buffer pH 6.8. The method obeys Beer’s law in the concentration range of 24-84μg/mL and 2-14μg/mL for fexofenadine HCl and montelukast sodium, resp. Different anal. parameters such as limit of detection, limit of quantitation, accuracy, and precision were determined as per International Council for Harmonisation guidelines Q2 (R1). Conclusion: The accuracy of the method was found to be 99.71% and 99.13% for fexofenadine HCl and montelukast sodium, resp. There is no interference shown by the excipients of the formulation in the method and the method can be used for routine quality control. In the experiment, the researchers used many compounds, for example, 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride (cas: 153439-40-8COA of Formula: C32H40ClNO4).

2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride (cas: 153439-40-8) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.COA of Formula: C32H40ClNO4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Method development and validation of fexofenadine hydrochloride in bulk and solid dosage form (tablets) by UV-visible spectrophotometry was written by Rojarani, B.;Swamy, D. Kumara. And the article was included in International Journal of Pharmacy and Pharmaceutical Research in 2022.Related Products of 153439-40-8 This article mentions the following:

A simple, accurate, and sensitive method was developed and validated for the determination of Fexofenadine hydrochloride (FEX.HCl) in bulk and tablet formulation. The method is based on the reaction of FEX.HCl with Di cyclohexyl carbodiimide (DCC) and 2-Nitrophenyl hydrazine (2-NPH) in solution, forms 2-Nitrophenyl hydrazide of Fexofenadine hydrochloride. Using ethanol as a solvent, and subsequently measured spectrophotometrically at 415nm. The reaction was extremely rapid at room temperature and absorbance values remained unchanged for at least 24h. Beer’s law was obeyed in the concentration range of 10-60μg/Ml within the detection limit of 0.62 and 0.68μg/mL and limit of quantification of 1.88 and 2.06μg/mL for FEX.HCl bulk and tablet derivatives resp. The anal. method was validated according to ICH guidelines. The correlation coefficient (r2) was found to be 0.999 and 0.998, % recovery was found to be 100.1 and 99.9, %RSD for repeatability was found to be 1.324 and 0.7824 (intraday), 1.365 and 0.7015 (interday), %RSD for intermediate precision for analyst 1 was found to be 0.435 & 0.520, for analyst 2%RSD was found to be 0.437 & 0.522 for FEX.HCl bulk and tablet derivatives resp. The robustness results of derivatives of FEX.HCl in bulk and tablets (20μg/mL) was performed by changing wavelengths and no noticeable changes were found on small changes in wavelength. Hence the method was found to be robust. The results obtained were compared statistically with those obtained by the official method and showed no significant differences regarding accuracy, precision & other anal. parameters. In the experiment, the researchers used many compounds, for example, 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride (cas: 153439-40-8Related Products of 153439-40-8).

2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride (cas: 153439-40-8) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Related Products of 153439-40-8

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem