Category: 14984-68-0

Nakashima, Toshio et al. published their research in Nagoya Medical Journal in 1958 | CAS: 14984-68-0

1-(2-((4-Chlorophenyl)(phenyl)methoxy)ethyl)piperidine hydrochloride (cas: 14984-68-0) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Name: 1-(2-((4-Chlorophenyl)(phenyl)methoxy)ethyl)piperidine hydrochloride

Action of new antihistaminics. Chemical constitution and pharmacological action of the derivatives of halogen-containing benzhydrylamine was written by Nakashima, Toshio;Hisada, Shiro. And the article was included in Nagoya Medical Journal in 1958.Name: 1-(2-((4-Chlorophenyl)(phenyl)methoxy)ethyl)piperidine hydrochloride This article mentions the following:

Ten hydrochlorides and citrates of aminoethyl benzhydryl ethers substituted at the amino group as well as in the ring were investigated for antihistaminic (I), anticholinergic (II), myotropic spasmolytic, antihistamine-shock (III) activities and acute toxicity. Para-substitution of one phenyl ring with a halogen and substitution of the Me2N group with a morpholine radical increases III potency and reduces activity in isolated organs. Toxicities of F, Cl, and Br decrease in this order. Substitution of NMe2 by piperidine radicals lowers III potency, except para-substitution with F, and increases I and II activities in the isolated organ. p-Fluoro substitutions of diphenylhydramine are slightly more active and less toxic in the citrate than in the hydrochloride. In the experiment, the researchers used many compounds, for example, 1-(2-((4-Chlorophenyl)(phenyl)methoxy)ethyl)piperidine hydrochloride (cas: 14984-68-0Name: 1-(2-((4-Chlorophenyl)(phenyl)methoxy)ethyl)piperidine hydrochloride).

1-(2-((4-Chlorophenyl)(phenyl)methoxy)ethyl)piperidine hydrochloride (cas: 14984-68-0) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Name: 1-(2-((4-Chlorophenyl)(phenyl)methoxy)ethyl)piperidine hydrochloride

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

De Boyace, Kevin et al. published their research in Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) in 2018 | CAS: 14984-68-0

1-(2-((4-Chlorophenyl)(phenyl)methoxy)ethyl)piperidine hydrochloride (cas: 14984-68-0) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Product Details of 14984-68-0

Modeling and Prediction of Drug Dispersability in Polyvinylpyrrolidone-Vinyl Acetate Copolymer Using a Molecular Descriptor was written by De Boyace, Kevin;Buckner, Ira S.;Gong, Yuchuan;Ju, Tzu-chi Rob;Wildfong, Peter L. D.. And the article was included in Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) in 2018.Product Details of 14984-68-0 This article mentions the following:

The expansion of a novel in silico model for the prediction of the dispersability of 18 model compounds with polyvinylpyrrolidone-vinyl acetate copolymer is described. The mol. descriptor R3m (at. mass weighted 3rd-order autocorrelation index) is shown to be predictive of the formation of amorphous solid dispersions at 2 drug loadings (15% and 75% weight/weight) using 2 preparation methods (melt quenching and solvent evaporation using a rotary evaporator). Cosolidified samples were characterized using a suite of anal. techniques, which included differential scanning calorimetry, powder X-ray diffraction, pair distribution function anal., polarized light microscopy, and hot stage microscopy. Logistic regression was applied, where appropriate, to model the success and failure of compound dispersability in polyvinylpyrrolidone-vinyl acetate copolymer. R3m had combined prediction accuracy greater than 90% for tested samples. The usefulness of this descriptor appears to be associated with the presence of heavy atoms in the mol. structure of the active pharmaceutical ingredient, and their location with respect to the geometric center of the mol. Given the higher electronegativity and at. volume of these types of atoms, it is hypothesized that they may impact the mol. mobility of the active pharmaceutical ingredient, or increase the likelihood of forming nonbonding interactions with the carrier polymer. In the experiment, the researchers used many compounds, for example, 1-(2-((4-Chlorophenyl)(phenyl)methoxy)ethyl)piperidine hydrochloride (cas: 14984-68-0Product Details of 14984-68-0).

1-(2-((4-Chlorophenyl)(phenyl)methoxy)ethyl)piperidine hydrochloride (cas: 14984-68-0) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Product Details of 14984-68-0

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

De Boyace, Kevin et al. published their research in Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) in 2018 | CAS: 14984-68-0

1-(2-((4-Chlorophenyl)(phenyl)methoxy)ethyl)piperidine hydrochloride (cas: 14984-68-0) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Product Details of 14984-68-0

Modeling and Prediction of Drug Dispersability in Polyvinylpyrrolidone-Vinyl Acetate Copolymer Using a Molecular Descriptor was written by De Boyace, Kevin;Buckner, Ira S.;Gong, Yuchuan;Ju, Tzu-chi Rob;Wildfong, Peter L. D.. And the article was included in Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) in 2018.Product Details of 14984-68-0 This article mentions the following:

The expansion of a novel in silico model for the prediction of the dispersability of 18 model compounds with polyvinylpyrrolidone-vinyl acetate copolymer is described. The mol. descriptor R3m (at. mass weighted 3rd-order autocorrelation index) is shown to be predictive of the formation of amorphous solid dispersions at 2 drug loadings (15% and 75% weight/weight) using 2 preparation methods (melt quenching and solvent evaporation using a rotary evaporator). Cosolidified samples were characterized using a suite of anal. techniques, which included differential scanning calorimetry, powder X-ray diffraction, pair distribution function anal., polarized light microscopy, and hot stage microscopy. Logistic regression was applied, where appropriate, to model the success and failure of compound dispersability in polyvinylpyrrolidone-vinyl acetate copolymer. R3m had combined prediction accuracy greater than 90% for tested samples. The usefulness of this descriptor appears to be associated with the presence of heavy atoms in the mol. structure of the active pharmaceutical ingredient, and their location with respect to the geometric center of the mol. Given the higher electronegativity and at. volume of these types of atoms, it is hypothesized that they may impact the mol. mobility of the active pharmaceutical ingredient, or increase the likelihood of forming nonbonding interactions with the carrier polymer. In the experiment, the researchers used many compounds, for example, 1-(2-((4-Chlorophenyl)(phenyl)methoxy)ethyl)piperidine hydrochloride (cas: 14984-68-0Product Details of 14984-68-0).

1-(2-((4-Chlorophenyl)(phenyl)methoxy)ethyl)piperidine hydrochloride (cas: 14984-68-0) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Product Details of 14984-68-0

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

09/9/2021 News Brief introduction of C20H25Cl2NO

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Recommanded Product: 1-(2-((4-Chlorophenyl)(phenyl)methoxy)ethyl)piperidine hydrochloride, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 14984-68-0, in my other articles.

Chemistry is an experimental science, Recommanded Product: 1-(2-((4-Chlorophenyl)(phenyl)methoxy)ethyl)piperidine hydrochloride, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 14984-68-0, Name is 1-(2-((4-Chlorophenyl)(phenyl)methoxy)ethyl)piperidine hydrochloride

The present invention provides a compound of new crystalline form I and form II of 1-[2-[(4-chlorophenyl)phenylmethoxy]ethyl]piperidinium monohydrochloride. The compound of form I has an X-ray diffraction pattern expressed in terms of 2-theta angles that comprises the following peaks: 15.5, 15.9, 17.6, 18.3, 18.8, 19.8, 20.2, 20.8, 21.2, 21.9, 22.9, 24.8, 25.7, 27.7, 28.0, and 30.6 degrees. In addition, the compound of form II has an X-ray diffraction pattern expressed in terms of 2-theta angles that comprises the following peaks: 14.8, 16.7, 17.3, 18.0, 18.2, 19.8, 20.5, 21.1, 22.8, 23.7, 25.0, 25.2, 25.4, 26.4, 27.8, 28.3, 29.0, 29.9, and 31.6 degrees.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Recommanded Product: 1-(2-((4-Chlorophenyl)(phenyl)methoxy)ethyl)piperidine hydrochloride, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 14984-68-0, in my other articles.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H23795N – PubChem

 

Brief introduction of 1-(2-((4-Chlorophenyl)(phenyl)methoxy)ethyl)piperidine hydrochloride

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 14984-68-0

Reference of 14984-68-0, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.14984-68-0, Name is 1-(2-((4-Chlorophenyl)(phenyl)methoxy)ethyl)piperidine hydrochloride, molecular formula is C20H25Cl2NO. In a Article，once mentioned of 14984-68-0

Organic cation transporter 1 (OCT1) plays a critical role in the hepatocellular uptake of structurally diverse endogenous compounds and xenobiotics. Here we identified competitive and noncompetitive OCT1-interacting ligands in a library of 1780 prescription drugs by combining in silico and in vitro methods. Ligands were predicted by docking against a comparative model based on a eukaryotic homologue. In parallel, high-throughput screening (HTS) was conducted using the fluorescent probe substrate ASP+ in cells overexpressing human OCT1. Thirty competitive OCT1 ligands, defined as ligands predicted in silico as well as found by HTS, were identified. Of the 167 ligands identified by HTS, five were predicted to potentially cause clinical drug interactions. Finally, virtual screening of 29 332 metabolites predicted 146 competitive OCT1 ligands, of which an endogenous neurotoxin, 1-benzyl-1,2,3,4-tetrahydroisoquinoline, was experimentally validated. In conclusion, by combining docking and in vitro HTS, competitive and noncompetitive ligands of OCT1 can be predicted.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 14984-68-0

Reference：
Piperidine – Wikipedia,
Piperidine | C5H23802N – PubChem

 

A new application about 1-(2-((4-Chlorophenyl)(phenyl)methoxy)ethyl)piperidine hydrochloride

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. HPLC of Formula: C20H25Cl2NO, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 14984-68-0, in my other articles.

Chemistry is an experimental science, HPLC of Formula: C20H25Cl2NO, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 14984-68-0, Name is 1-(2-((4-Chlorophenyl)(phenyl)methoxy)ethyl)piperidine hydrochloride

The disclosure provides methods to prevent, inhibit or treat one or more symptoms associated with epilepsy or encephalopathies in a mammal, comprising: administering to the mammal, e.g., a composition having one of more of compounds of formula (I)-(XXXVI).

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. HPLC of Formula: C20H25Cl2NO, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 14984-68-0, in my other articles.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H23800N – PubChem

 

A new application about 1-(2-((4-Chlorophenyl)(phenyl)methoxy)ethyl)piperidine hydrochloride

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 14984-68-0, help many people in the next few years.Recommanded Product: 14984-68-0

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Recommanded Product: 14984-68-0, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 14984-68-0, Name is 1-(2-((4-Chlorophenyl)(phenyl)methoxy)ethyl)piperidine hydrochloride, molecular formula is C20H25Cl2NO. In a Patent, authors is £¬once mentioned of 14984-68-0

METHODS OF TREATING EPILEPSY AND RELATED NEUROLOGICAL CONDITIONS

The disclosure provides methods to prevent, inhibit or treat one or more symptoms associated with epilepsy or encephalopathies in a mammal, comprising: administering to the mammal, e.g., a composition having one of more of compounds of formula (I)-(XXXX).

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 14984-68-0, help many people in the next few years.Recommanded Product: 14984-68-0

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H23799N – PubChem

 

Awesome and Easy Science Experiments about 14984-68-0

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.14984-68-0. In my other articles, you can also check out more blogs about 14984-68-0

14984-68-0, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 14984-68-0, Name is 1-(2-((4-Chlorophenyl)(phenyl)methoxy)ethyl)piperidine hydrochloride, molecular formula is C20H25Cl2NO. In a Article, authors is Rezeki, Yulianto Agung£¬once mentioned of 14984-68-0

Formation of electrosprayed composite nanoparticles from polyvinylpyrrolidone/mangosteen pericarp extract

Mangosteen pericarp contains a lot of alpha-mangostin compounds which has very high antioxidant activity. Unfortunately, it has a low solubility in aqueous solution in which for drug delivery application. This paper reports the synthesis of polyvinylpyrrolidone (PVP) nanoparticles loaded with mangosteen pericarp extract (MPE) using the ES method. PVP was trusted as a hydrophilic matrix to carry MPE. The composition of the precursor solution and solution flow rate during the ES process were varied to control the formation of PVP/MPE composite nanoparticles. PVP/MPE composite particles obtained have some wrinkles on their surface and have a geometric average diameter range of 640 to 1534 nm with a geometric standard deviation of 1.35 to 1.65. Increasing the electrical conductivity of the precursor solution resulted in a decrease of nanoparticles’ average diameter. Also, the greater the flow rate, the larger the particles formed. The results agreed well with the droplet scaling relations for EHDA by Chen and Pui. Peak shifts in Fourier-transform infrared spectra of PVP/MPE composite nanoparticles indicated hydrogen bond formation between PVP and MPE. It also showed that MPE was successfully encapsulated in PVP matrix. Crystalline peaks of MPE disappear in the X-ray diffraction patterns of PVP/MPE composite nanoparticles, indicating amorphization of MPE after being electrosprayed by PVP. The differential scanning calorimetry study confirmed a hygroscopicity of PVP. The thermogram shows a broad endothermic peak from around 50 to 100 C as a result of dehydration. In this study, the use of flow rate during the electrospraying process only affected the geometric average diameter, did not change the functional groups, thermal properties, and crystallinity of PVP/MPE particles because they came from the same precursor solution. The results here demonstrate that the ES method can be used for polymeric-nanoparticle-composite production and as an innovation in the field of drug delivery application.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.14984-68-0. In my other articles, you can also check out more blogs about 14984-68-0

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H23803N – PubChem