Category: 149669-43-2

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 149669-43-2, name is 5-Fluoro-3-(piperidin-4-yl)-1H-indole, introducing its new discovery. Product Details of 149669-43-2

The synthesis and biological evaluation of a series of substituted dipiperidine alcohols are described. Structure-activity relationship studies led to the discovery of potent CCR2 antagonists displaying IC50 values in the nanomolar or subnanomolar range. The cinnamoyl compounds had higher binding affinities than the corresponding urea analogs.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 149669-43-2 is helpful to your research. Product Details of 149669-43-2

Reference：
Piperidine – Wikipedia,
Piperidine | C5H17638N – PubChem

 

Reference of 149669-43-2, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.149669-43-2, Name is 5-Fluoro-3-(piperidin-4-yl)-1H-indole, molecular formula is C13H15FN2. In a article，once mentioned of 149669-43-2

As part of our research program toward new, potential antidepressants, a series of unsymmetrical ureas has been prepared and evaluated as 5-HT reuptake inhibitors with 5-HT(1B/1D) antagonistic activities. The design of these compounds was based on coupling of various indole derivatives, previously shown to inhibit 5-HT reuptake, to three different aniline moieties, which are part of known 5-HT(1B/1D) ligands. Binding experiments in rat frontal cortex using [125I]iodocyanopindolol, in calf striatum using [3H]5-HT, and in rat hippocampus using [3H]8-OH-DPAT as radioligands, respectively, revealed significantly higher affinity at the 5-HT(1B) receptor as compared to the affinities for the 5-HT(1A) and 5-HT(1D) receptors for a number of compounds, among them 4-(5-fluoro-1H-indol-3-yl)piperidine-1- carboxylic acid [4-methoxy-3(4-methylpiperazin-1-yl)phenyl]amide (5), the corresponding 4-fluoro-1H-indol-3-yl analogue 21a, and the corresponding 6- fluoro-1H-indol-3-yl analogue 21b. Conformational restriction of the aniline moiety in 5 only slightly enhanced the 5-HT(1B) affinity, whereas introduction of an aniline moiety with higher conformational flexibility resulted in a less potent 5-HT(1B) receptor ligand as compared to 5. The functional 5-HT(1B/1D) antagonistic activity was investigated using the rabbit saphenous vein model as well as the [3H]5-HT release from guinea pig cortical slices. All new compounds tested in the rabbit saphenous vein model were shown to antagonize the sumatriptan-evoked contractile responses with pA2 values ranging from 7.3 to 8.7. These observations were consistent with the results of the cortical slice model, in which the ureas were found to block the sumatriptan-induced inhibition of potassium-evoked [3H]5-HT release. The 5-HT reuptake inhibition of the ureas determined in rat brain synaptosomes was found to be either increased or decreased as compared to the uncoupled indole derivatives indicating that the reuptake inhibition shown by the ureas is not only due to the indole part but also affected by the aniline moiety of the molecule. Among this series of compounds described the ureas 5, 21a, and 21b seem to be the most interesting candidates showing both 5-HT reuptake inhibition and 5-HT(1B/1D) antagonism in vitro. This dual pharmacological profile should in theory lead to a pronounced enhancement in serotonergic neurotransmission and consequently to a more efficient treatment of depression.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H17650N – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. Formula: C13H15FN2. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent，Which mentioned a new discovery about 149669-43-2

The invention relates to 4-substituted 1-aminocyclohexane derivatives of general formula (I), to a method for the production thereof, to medicaments containing said compounds and to the utilization of 4-substituted 1-aminocyclohexane derivatives for the production of medicaments.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H17646N – PubChem

 

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Safety of 5-Fluoro-3-(piperidin-4-yl)-1H-indole, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 149669-43-2, Name is 5-Fluoro-3-(piperidin-4-yl)-1H-indole, molecular formula is C13H15FN2. In a Patent, authors is ，once mentioned of 149669-43-2

This invention provides novel 5-HT1F agonists which are useful for the treatment of migraine and associated disorders having the following formula: STR1 wherein A, B, X, Y, Ar and n are defined in the specification.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H17636N – PubChem

 

Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 149669-43-2, molcular formula is C13H15FN2, introducing its new discovery. HPLC of Formula: C13H15FN2

SULFAMIDE-METALLOPROTEASE INHIBITORS

This invention relates to sulfamides of formula (I) STR1 that are inhibitors of metalloproteases, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, HPLC of Formula: C13H15FN2, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 149669-43-2

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Piperidine – Wikipedia,
Piperidine | C5H17633N – PubChem

 

Synthetic Route of 149669-43-2, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.149669-43-2, Name is 5-Fluoro-3-(piperidin-4-yl)-1H-indole, molecular formula is C13H15FN2. In a article£¬once mentioned of 149669-43-2

4-AMINOMETHYL-1-ARYL-CYCLOHEXYLAMINE DERIVATIVES

The invention concerns 4-aminomethyl-1-aryl-cyclohexylamine derivatives, methods for producing same, medicines containing said compounds and the use of 4-aminomethyl-1-aryl-cyclohexylamine derivatives for producing medicines.

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Reference£º
Piperidine – Wikipedia,
Piperidine | C5H17648N – PubChem