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The thermal decomposition of the byproducts of the biodiesel process was studied by thermoanalytical methods. Deoiled algae cake and jatropha seed deoiled cake were pyrolyzed and the catalytic effects of silica supported iron catalysts (Fe/FSM-16 and Fe/SBA-15) and magnetite (Fe3O4) were tested. The evolution profiles of the decomposition products as well as the thermal stability of the samples were determined by thermogravimetry/mass spectrometry (TG/MS). The formation of the volatile products was monitored by pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS). The composition and the amounts of the gaseous products changed significantly in the presence of the silica supported iron catalysts: the yield of hydrogen and carbon monoxide considerably increased above the decomposition temperature of 400 C. Both silica supported iron catalysts had important effects on the yield of the products originating from carbohydrates and lignins. The formation of anhydrosugars and phenolic compounds was hindered, while the evolution of aromatic and aliphatic hydrocarbons was enhanced. Fe/FSM-16 proved to be more efficient than Fe/SBA-15 and Fe3O4 catalysts. The thermal decomposition of the protein content of the samples resulted in the formation of 2,5-diketopiperazines and smaller molecules (e.g., ammonia). The silica supported iron catalysts had a special effect: their presence promoted the reaction of fatty acid esters and ammonia resulting in the formation of alkyl nitriles during the thermal decomposition.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H5500N – PubChem

 

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A series of eleven new 2-aminoethyl- and 3-aminopropyl borinate derivatives with a coordinative N?B bond has been synthesized by condensation reactions between piperidine- as well as piperazine alcohols and diphenylborinic acid. The products obtained are analogous to N-spiro compounds and bicyclic systems and have been characterized by spectroscopic methods and X-ray crystallography. Thereby the N?B bond and the geometry of this new heterocyclic systems have been studied in more detail.

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Piperidine – Wikipedia,
Piperidine | C5H5679N – PubChem

 

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Dye compositions for dyeing keratin fibres, comprising at least one oxidation base and at least one coupler chosen from 6-alkoxy-2,3-diaminopyridine derivatives of formula (I) as defined herein and the addition salts thereof; the use of the compositions for dyeing keratin fibres; and the dyeing processes using the compositions; as well as at least one entity chosen from novel 6-alkoxy-2,3-diaminopyridine compounds and their addition salts thereof that are useful as couplers.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H5637N – PubChem

 

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Type 5 17beta-hydroxysteroid dehydrogenase (17beta-HSD5), also known as aldo-keto reductase 1C3 (AKR1C3), is a member of the aldo-keto reductase superfamily of enzymes and is expressed in the human prostate. One of the main functions of 17beta-HSD5 is to catalyze the conversion of the weak androgen, androstenedione, to the potent androgen, testosterone. The concentration of intraprostatic 5alpha-dihydrotestosterone (DHT) in patients following chemical or surgical castration has been reported to remain as high as 39% of that of healthy men, with 17beta-HSD5 shown to be involved in this androgen synthesis. Inhibition of 17beta-HSD5 therefore represents a promising target for the treatment of castration-resistant prostate cancer (CRPC). To investigate this, we conducted high-throughput screening (HTS) and identified compound 2, which displayed a structure distinct from known 17beta-HSD5 inhibitors. To optimize the inhibitory activity of compound 2, we first introduced a primary alcohol group. We then converted the primary alcohol group to a tertiary alcohol, which further enhanced the inhibitory activity, improved metabolic stability, and led to the identification of compound 17. Oral administration of compound 17 to castrated nude mice bearing the CWR22R xenograft resulted in the suppression of androstenedione (AD)-induced intratumoral testosterone production. Compound 17 also demonstrated good isoform selectivity, minimal inhibitory activity against either CYP or hERG, and enhanced pharmacokinetic and physicochemical properties.

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Piperidine – Wikipedia,
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The present application provides methods of using the aminoindane compounds of formula (I) or (II) in treating an overactive bladder or interstitial cystitis by administering one or more of the compounds to a patient.

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Piperidine – Wikipedia,
Piperidine | C5H5525N – PubChem

 

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Substituted sulfonamide compounds corresponding to the formula I: processes for the preparation thereof, pharmaceutical composition containing these compounds and the use of substituted sulfonamide compounds for the preparation of pharmaceutical compositions

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Piperidine – Wikipedia,
Piperidine | C5H5561N – PubChem

 

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Asymmetric synthesis of (-)-isooncinotine, a 22-membered lactam of spermidine alkaloid, starting from resolution of 2-piperidineethanol with (S)-10-camphorsulfonic acid is reported. Michael addition, amidations, and aluminum hydride reduction were applied to form the moiety of spermidine. Retro-Michael addition was observed when beta-amido- and beta-amino-propionitriles were reduced by LAH. The effects of LAH versus AlH3 were discussed. The synthesis of the skeleton of this macrolide is achieved with ring-closing metathesis of the diene prepared from acylation of the spermidine.

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Piperidine – Wikipedia,
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Aqueous piperazine (PZ) blended with a tertiary or hindered amine combines the high CO2capacity of the tertiary or hindered amine with the fast rate of PZ. For flue gas CO2capture, the optimum pKa(that which offers the highest CO2cyclic capacity) of a mono-tertiary amine blended with PZ is 9.1. A generic Aspen Plus model for PZ/tertiary amine was developed to predict the CO2vapor-liquid-equilibrium (VLE) from the pKaof the tertiary amine. The polarity of the tertiary amine also affects the CO2solubility of the PZ/tertiary amine. Hindered amines that form little carbamate show similar CO2VLE to tertiary amines with the same pKa, when blended with PZ. The CO2absorption rate of most 2.5 m PZ/2.5 m tertiary amines was slightly slower than 2.5 m PZ, probably due to the higher viscosity of the blends.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H5664N – PubChem

 

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Treatment of 2-(2′-alkenyl)-piperidine boranes with iodine or triflic acid induces internal hydroboration with high regiocontrol, even with a terminal alkene (R H). Good stereocontrol is possible for the N-benzyl substrates. Comparisons with acyclic model structures show that the source of regiocontrol with the terminal alkene is due to a steric effect of the axial piperidine C(3,5) hydrogens that destabilize the competing bridged bicyclic transition state.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H5485N – PubChem

 

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N-Protected beta-amino aldehydes having the nitrogen in a ring are easily converted into Morita-Baylis-Hillman adducts; O-acetylation and N-deprotection result in spontaneous cyclization to bicyclic structures having nitrogen at a bridgehead. The Royal Society of Chemistry 2005.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H5593N – PubChem