Category: 14813-01-5

14813-01-5, 1-Benzylpiperidin-3-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

N-benzyl-3-piperidinol (1.90 g, 9.93 mmol) was dissolved in THF: MeOH 1: 1, with 20% Pd/C (0.5 g) and subjected to 50 psi of hydrogen gas for 16 hours. The crude product was then filtered through celite and then concentrated in vacuo. The crude product was determined to be pure (0.985 g, 98%) BY LHNMR (400 MHz, CDC13) : 8 1.36 – 1. 56 (m, 2H), 1.68-1. 81 (m, 2H), 2.60-2. 76 (m, 3 H), 2.92 (dd, 1H, J=2.7, 11.9 Hz), 3.67 (sept, 1H, J=3.3 Hz)., 14813-01-5

As the paragraph descriping shows that 14813-01-5 is playing an increasingly important role.

Reference：
Patent; WARNER-LAMBERT COMPANY LLC; WO2005/26145; (2005); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

14813-01-5, 1-Benzylpiperidin-3-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The alcohol (1.0 equiv.) was dissolved in pyridine at roomtemperature. The solution was stirred and N-ethyl-N-methylcarbamoylchloride (1.2 equiv.) was added. The reaction mixturewas stirred under argon at reflux (120 C) for 24 h. The mixturewascooled to room and the solvent was evaporated. The crude productwas purified by flash column chromatography., 14813-01-5

The synthetic route of 14813-01-5 has been constantly updated, and we look forward to future research findings.

Reference：
Article; ?akelj, Simon; Brazzolotto, Xavier; Gobec, Stanislav; Juki?, Marko; Knez, Damijan; Ko?ak, Urban; Kos, Janko; Nachon, Florian; Pi?lar, Anja; Stra?ek, Nika; Zahirovi?, Abida; European Journal of Medicinal Chemistry; vol. 197; (2020);,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

14813-01-5, 1-Benzylpiperidin-3-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Then, 11.8 g of the 1-benzyl-3-hydroxypiperidine and 5.6 g of diketene were reacted similarly as in Reference Example 1, and the reaction product was purified by silica gel column chromatography (eluent:chloroform:methanol=9:1 v/v), to obtain 10.65 g of acetoacetic acid-N-benzyl-3-piperidinyl ester (yield: 62.5%). This was used in the reaction of Example 4 without distillation. NMR spectrum (CDCl3, delta): 1.30-1.90(4H, broad), 2.10-2.95(4H, broad), 2.27(3H, s), 3.43(2H, s), 3.54(2H, s), 4.73-5.2(1H, broad), 7.30(5H, s)

14813-01-5, 14813-01-5 1-Benzylpiperidin-3-ol 85773, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; Kyowa Hakko Kogyo Co., Ltd.; US4448964; (1984); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

14813-01-5, 1-Benzylpiperidin-3-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The alcohol (1.0 equiv.) was dissolved in CH2Cl2 at room temperature.The solution was stirred, and isocyanate (1.2 equiv.) wasadded, followed by 4-DMAP (0.1 equiv.). After 24 h, the solvent wasevaporated and the crude product was purified by flash columnchromatography., 14813-01-5

14813-01-5 1-Benzylpiperidin-3-ol 85773, apiperidines compound, is more and more widely used in various fields.

Reference：
Article; ?akelj, Simon; Brazzolotto, Xavier; Gobec, Stanislav; Juki?, Marko; Knez, Damijan; Ko?ak, Urban; Kos, Janko; Nachon, Florian; Pi?lar, Anja; Stra?ek, Nika; Zahirovi?, Abida; European Journal of Medicinal Chemistry; vol. 197; (2020);,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

14813-01-5, 1-Benzylpiperidin-3-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

866.3 mg of the 1-benzyl-3-hydroxypiperidine crude product obtained was dissolved in 6 mL of chloroform, to which, under ice cooling, 0.95 mL of triethylamine and 0.42 mL of methanesulfonyl acid chloride were sequentially added, and stirred at the same temperature for 30 minutes. To the reaction mixture, saturated sodium bicarbonate was added, extracted with chloroform, the extract was washed with saturated saline, and dried on anhydrous sodium sulfate. The solvent was evaporated to obtain 1.15 g of methanesulfonic acid (1-benzyl-piperidin-3-yl)methylester crude product as an orange oil. Without further purification, this was used as the feed material for the next reaction.

14813-01-5, As the paragraph descriping shows that 14813-01-5 is playing an increasingly important role.

Reference：
Patent; Kitamura, Takahiro; Yamada, Hajime; Takemura, Shunji; Ashikawa, Masanori; Ishikawa, Tetsuya; Miyake, Yoshiharu; Kouketsu, Akiyasu; Sato, Seiichi; Ishiwata, Hiroyuki; Tabunoki, Yuichiro; Shibasaki, Manabu; Ozawa, Takatoshi; Shigemi, Ryota; Doi, Takeshi; Tamura, Masahiro; US2011/237590; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14813-01-5,1-Benzylpiperidin-3-ol,as a common compound, the synthetic route is as follows.

1000ml three necked flask n-Benzyl-3-hydroxypiperidine (95.6 g, 0.5 mol) was added,2-butanone 478 ml of a solution of L-CSA (69.6 g, 0.3 mol) in 290 ml of 2-butanone was stirred at room temperature for 1 hour, and the precipitated solid appeared, kept at 0 C for 2 hours, filtered, washed with 2-butanone 30 ml, (S) -1-benzyl-3-hydroxypiperidine camphorsulfonate. (Ee: 75%)(Theory: 105.9G)., 14813-01-5

As the paragraph descriping shows that 14813-01-5 is playing an increasingly important role.

Reference：
Patent; ABA Chemicals Corporation; Lin, ZhiGang; Xu, Jun; Liu, YanQin; Que, limin; Jiang, yueheng; CAI, Tong; (13 pag.)CN103864673; (2016); B;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14813-01-5,1-Benzylpiperidin-3-ol,as a common compound, the synthetic route is as follows.

Step 1: To a stirred solution of [5] (l .Og, 5.2mmol) in DCM (20.0ml) was added TEA (1.9g, 15.2mmol) at room temperature. After an additional stirring for 5 minutes at same temperature, Mesyl chloride (0.55ml, 7.8mmol) was added. The reaction temperature was allowed to stirred at this temperature for 3h. TLC showed complete consumption of starting material. Water (100 ml) was added and organic layer was extracted with ethyl acetate (2 x 100 ml). The combined organic layers were washed with water, brine and dried over sodium sulphate. The organic layer was concentrated to afford light brown sticky material [9] which was used further without any purification (l.lg, 78%).Analytical Data: [9]ESIMS: 270 [M++l]., 14813-01-5

14813-01-5 1-Benzylpiperidin-3-ol 85773, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; SPHAERA PHARMA PVT. LTD.; DRUG DISCOVERY RESEARCH CENTRE; DUGAR, Sundeep; MAHAJAN, Dinesh; RAI, Santosh Kumar; RAO, Kanury; SINGH, Varshneya; WO2015/181837; (2015); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

14813-01-5, 1-Benzylpiperidin-3-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

14813-01-5, To a mixture of 0.50 g (2.62 mmol) of rac-2 and 1 ml of dry pyridine 0.57 ml (3.50 mmol) of butanoic anhydride was added at 0 C under nitrogen. The resulting mixture was stirred over night at room temperature. The reaction mixture was diluted with dichloromethane and then extracted with a saturated sodium carbonate solution (2 x 4 ml) and with 4 ml of a saturated sodium chloride solution. The organic phase was dried with sodium sulfate and then concentrated at reduced pressure to give 0.65 g (2.49 mmol) of rac-5 as a pale yellow oil (95% yield). 1H NMR (300 MHz,CDCl3, d ppm): 0.98 (t, 3H, J = 5.9 Hz); 1.43-1.45 (m, 1H); 1.63-1.90 (m, 3H); 2.31-2.40 (m, 4H); 2.46 (m, 2H), 2.67-2.83 (m,2H); 3.58-3.64 (m, 2H); 4.85-4.89 (m, 1H); 7.22-7.31 (m, 5H); TLC Rf = 0.60.

14813-01-5 1-Benzylpiperidin-3-ol 85773, apiperidines compound, is more and more widely used in various fields.

Reference：
Article; Tofani, Giorgio; Petri, Antonella; Piccolo, Oreste; Tetrahedron Asymmetry; vol. 26; 12-13; (2015); p. 638 – 643;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem