Category: 14813-01-5

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14813-01-5,1-Benzylpiperidin-3-ol,as a common compound, the synthetic route is as follows.

General procedure: The alcohol (1.0 equiv.) was dissolved in CH2Cl2 at room temperature.The solution was stirred, and isocyanate (1.2 equiv.) wasadded, followed by 4-DMAP (0.1 equiv.). After 24 h, the solvent wasevaporated and the crude product was purified by flash columnchromatography.

14813-01-5, As the paragraph descriping shows that 14813-01-5 is playing an increasingly important role.

Reference：
Article; ?akelj, Simon; Brazzolotto, Xavier; Gobec, Stanislav; Juki?, Marko; Knez, Damijan; Ko?ak, Urban; Kos, Janko; Nachon, Florian; Pi?lar, Anja; Stra?ek, Nika; Zahirovi?, Abida; European Journal of Medicinal Chemistry; vol. 197; (2020);,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14813-01-5,1-Benzylpiperidin-3-ol,as a common compound, the synthetic route is as follows.,14813-01-5

Under ultrasound, 10 g of dihydropyridine main ring , i.e.,[2,6-dimethyl -4-(3-nitrophenyl)-l ,4-dihydropyridine-3,5-dicarboxylic acid monomethyl ester] was placed into 200 mL reaction flask, and 14 mL Nu,Nu-dimethylformamide (DMF) and 56 mL dichloromethane was added. To the resultant homogeneous suspension was added 2.4 mL of thionyl chloride under ice-bath, then the mixture was stirred for 1 hour to obtain a clear solution.Then, 6.3 g of pyridine (alcohol) side chain, i.e., [l-benzyl-3 -hydroxypiperidine] was added and stirred for 2.5 hours under ice-bath.The reaction solution was washed with 40 mL water (x 4) and 40 mL saturated saline solution (x 1). The dichloromethane solution was dried for two hours by adding 4 g of anhydrous sodium sulfate. Then, sodium sulfate solid was removed by filtering, and dichloromethane was recycled under reduced pressure to obtain a yellow to red crude crystal (herein after referred to as crude crystal of benidipine hydrochloride). The crude crystal mentioned above was dissolved in 100 mL acetone, and ultrasounded at 150 W and 40 MHz for 7 minutes, filtered under reduced pressure and dried to obtain 5.9 g of crystal as yellow powder (yield 36.2%)

The synthetic route of 14813-01-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; HEFEI BEINI MEDICAL TECHNOLOGY COMPANY, LTD; ZHANG, Zhaoyong; WO2012/142815; (2012); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

14813-01-5, 1-Benzylpiperidin-3-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1000ml three bottles, a solution of D-CSA (58 g, 0.25 mol) in 116 ml of isopropanol was added dropwise to 478 ml of isopropanol, and the mixture was stirred at room temperature for 1 hour to precipitate a solid. 0 C for 2 hours, filtered, washed with cold isopropanol (30 ml) and dried to give 75 g of (R) -1-benzyl-3-hydroxypiperidine camphorsulfonate. (Ee: 95%) (theory: 105.9 g). (R) -1-benzyl-3-hydroxypiperidine camphorsulfonate having a 95% ee value was recrystallized from 3-fold amounts of isopropanol to give (R) -1-benzyl- Camphorsulfonate (99% ee)., 14813-01-5

The synthetic route of 14813-01-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; ABA Chemicals Corporation; Lin, ZhiGang; Xu, Jun; Liu, YanQin; Que, limin; Jiang, yueheng; CAI, Tong; (13 pag.)CN103864673; (2016); B;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

14813-01-5, 1-Benzylpiperidin-3-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 29; Preparation of 3-(1-Naphthylsulfonyl)-5-(piperidin-3-yloxy)-1H-indazole; 1-Benzyl-3-(4-nitrophenoxy)piperidine; A mixture of 1-benzyl-3-hydroxypiperidine (2.0 g, 10 mmoles), p-fluoronitrobenzene (1.06 ml, 12 mmoles) and sodium hydride (0.285 g, 12 mmoles) in DMF was stirred at room temperature for 3 hours, diluted with H2O and extracted with EtOAc. The extracts were combined, washed sequentially with water and brine, dried over Na2SO4 and concentrated under vacuum. The resultant residue was purified by flash chromatography using as eluent 50% EtOAc/hexane to afford the title compound (3.0 g, 9.43 mmoles).

14813-01-5, The synthetic route of 14813-01-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Wyeth; US2007/54896; (2007); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14813-01-5,1-Benzylpiperidin-3-ol,as a common compound, the synthetic route is as follows.

1-Benzyl-3-piperidinol (20 g), toluene (200 mL), methyl acetoacetate (24.3 g), Manganese sulfate (3.54 g) was added to a 500 mL reaction flask, heated to reflux for 6 hours, and detected by HPLC. The remaining 25.6% of 1-benzyl-3-piperidinol, plus an atmospheric distillation unit, distills off the ethanol produced by the reaction. The reaction was completed in 2 hours, cooled to 0~10 C, adjusted to a pH of about 3, and the product was extracted with water (50 mL × 2). The aqueous phases were combined and the pH of the aqueous phase was adjusted to approximately 7 and extracted with ethyl acetate (50 mL×2). The combined organic layers were washed with brine (30 mL×2) Concentrated to dryness gave a yellow oil (26.5 g)., 14813-01-5

The synthetic route of 14813-01-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; Tianjin Changyuan Pharmaceutical Technology Co., Ltd.; Chi Fangfei; Ying Zixiang; Liu Wenjuan; Mo Lan; (9 pag.)CN104529872; (2018); B;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

14813-01-5, 1-Benzylpiperidin-3-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1-Benzyl-3-piperidinol (600 g), toluene (6 L), ethyl acetoacetate (490.2 g), boric acid (19.5 g) were added to a 10 L reaction flask. Heated to reflux overnight, HPLC detection, The remaining 2-6.2% of 3-benzyl-3-piperidinol was added to the atmospheric distillation apparatus to distill off the ethanol produced by the reaction. Complete the reaction in 2 hours, cool to 0~10 C, adjust the pH to about 3, and extract the product with water (1 L × 2). The aqueous phase was combined, and the pH of the aqueous phase was adjusted to about 7 and extracted with ethyl acetate (1L×2). Wash with saturated brine (500 mL×2), dry over anhydrous sodium Concentrated to dryness afforded 786.1 g of a yellow oil., 14813-01-5

As the paragraph descriping shows that 14813-01-5 is playing an increasingly important role.

Reference：
Patent; Tianjin Changyuan Pharmaceutical Technology Co., Ltd.; Chi Fangfei; Ying Zixiang; Liu Wenjuan; Mo Lan; (9 pag.)CN104529872; (2018); B;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14813-01-5,1-Benzylpiperidin-3-ol,as a common compound, the synthetic route is as follows.

Step 3: To a solution of [3](1.00 g, 5.23 mmol) in benzene (90 mL),sodium (1 10 mg) was added. After refluxing for 2.5 h, a solution of methylbenzilate (1.27 g, 5.23 mmol) was added and the reaction refluxed overnight. The benzene was evaporated in vacuo and the residue purified by flash chromatography (eluted first with 20% EtOAc/Hexane, then 5%MeOH/CH2Cl2) to give [1O04] as transparent liquid (981 mg,46%).Analytical Data: [1004] ESIMS: 402[M++1]

14813-01-5, As the paragraph descriping shows that 14813-01-5 is playing an increasingly important role.

Reference：
Patent; SPHAERA PHARMA PVT. LTD.; DRUG DISCOVERY RESEARCH CENTRE; DUGAR, Sundeep; MAHAJAN, Dinesh; RAI, Santosh Kumar; RAO, Kanury; SINGH, Varshneya; WO2015/181837; (2015); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.14813-01-5,1-Benzylpiperidin-3-ol,as a common compound, the synthetic route is as follows.

To a solution of 0.50 g (2.62 mmol) of rac-2 in 1 ml of dry pyridine cooled to 0 C, 0.35 ml (3.70 mmol) of acetic anhydride was added under nitrogen. The resulting mixture was stirred overnight at room temperature. The reaction mixture was diluted with toluene (3 x 3 ml) and concentrated under reduced pressure to give 0.57 g (2.45 mmol) of rac-4 as a pale yellow oil (94% yield). 1H NMR (300 MHz, CDCl3, d ppm): 1.46-1.94 (m, 4H); 2.04 (s,3H); 2.10-2.21 (m, 2H); 2.45-2.79 (m, 2H); 3.57 (s, 2H); 4.84 (s,1H); 7.22-7.45 (m, 5H); TLC Rf = 0.59.

14813-01-5, 14813-01-5 1-Benzylpiperidin-3-ol 85773, apiperidines compound, is more and more widely used in various fields.

Reference：
Article; Tofani, Giorgio; Petri, Antonella; Piccolo, Oreste; Tetrahedron Asymmetry; vol. 26; 12-13; (2015); p. 638 – 643;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

14813-01-5, 1-Benzylpiperidin-3-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1: To a stirred solution of [5] (2.0g, 10.47mmol), vinyl acetate (10.0ml, lOO.Ommol) was added at room temperature. After an additional stirring for 5 minutes at same temperature, PS-IM (0.20g, 10%) was added. The reaction temperature was allowed to increase up to 40C and stirring was continued for 16 h. Reaction mixture was passed through the bed of celite and evaporated to dryness which was further purified using silica gel column chromatography using 10% ethyl acetate/hexane as eluent to afford [6](0.9g, 45%)and [7] (0.8g, 40%) as transparent sticky material. Analytical Data: [6] ESIMS: 192 [M++1][7]ESIMS: 234 [M++l]., 14813-01-5

The synthetic route of 14813-01-5 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; SPHAERA PHARMA PVT. LTD.; DRUG DISCOVERY RESEARCH CENTRE; DUGAR, Sundeep; MAHAJAN, Dinesh; RAI, Santosh Kumar; RAO, Kanury; SINGH, Varshneya; WO2015/181837; (2015); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

14813-01-5, 1-Benzylpiperidin-3-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,14813-01-5

1000ml three necked flask, N-benzyl-3-hydroxypiperidine (95.6 g, 0.5 mol), 2-Butanone (478 ml) was added dropwise a solution of L-CSA (58 g, 0.25 mol) in 290 ml of 2-butanone at room temperature Stirring for 1 hour, precipitation of solid appeared, 0 heat 2 hours, filtration, 2-butanone 30ml washing,Dried to obtain 88 g of (S) -1-benzyl-3-hydroxypiperidine camphorsulfonate. (Ee: 93%) (theory: 105.9 g).

14813-01-5 1-Benzylpiperidin-3-ol 85773, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; ABA Chemicals Corporation; Lin, ZhiGang; Xu, Jun; Liu, YanQin; Que, limin; Jiang, yueheng; CAI, Tong; (13 pag.)CN103864673; (2016); B;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem