With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.147804-30-6,tert-Butyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate,as a common compound, the synthetic route is as follows.
A 70% solution of hydrofluoric acid in pyridine (12 mL) was added drop-wise to a solution of intermediate 16 (10 [G)] in anhydrous DCM (200 mL) previously cooled to-40C under a Nitrogen atmosphere. After 1.5 hours, further hydrofluoric acid in pyridine (6 mL) was added. After stirring for further 15 minutes, a saturated sodium hydrogen carbonate solution was added. The layers were separated and the aqueous phase was extracted three times with further DCM. The combined organic extracts were washed with brine, dried and concentrated [IN VACUO] to a residue which was purified by flash chromatography (CH/AcOEt 6: 4) to give the pure title compound (990 mg) and a fraction of title compound (6.01 [G)] impure of pyridine. Thus, this material was diluted with AcOEt and washed three times with a pH3 buffer solution and brine. The organic layer was dried and concentrated in vacuo to give a further amount of title compound (5.12 g). T. [I.] c.: CH/AcOEt 1: 1, [RF=0.] 35. NMR [(D6-DMSO)] : [8] (ppm) 4.99 (t, [1H)] ; 3.79 (m, 2H); 3.43 (dd, 2H); 3.01 (bt, 2H); 1.8-1. 4 (m, 4H); 1.43 (s, 9H)., 147804-30-6
147804-30-6 tert-Butyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate 22135564, apiperidines compound, is more and more widely used in various fields.
Reference£º
Patent; GLAXO GROUP LIMITED; WO2004/5255; (2004); A1;,
Piperidine – Wikipedia
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