Category: 147769-93-5

Chen, Hao et al. published their research in Shandong Huagong in 2012 | CAS: 147769-93-5

(S)-3-Methyl-1-(2-(piperidin-1-yl)phenyl)butan-1-amine (cas: 147769-93-5) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising 伪-glucosidase inhibitors. The former are analogs of DNJ with an improved 伪-glucosidase inhibitory profile than that of DNJ. Boisson et al.Formula: C16H26N2

Synthesis of oral antidiabetic medicine repaglinide was written by Chen, Hao;Zhao, Yong;Zheng, Rong-rong;Fan, Ling-ling. And the article was included in Shandong Huagong in 2012.Formula: C16H26N2 This article mentions the following:

Repaglinide was synthesized from 4-carboxymethyl-2-ethoxybenzoic acid by esterification and hydrolysis to give 4-carboxymethyl-3-Et 2-ethoxybenzoate, which was condensed with S (+)-1-(2-piperidine-phenyl)-3-methylbutylamine in the presence of boric acid and dichloromethane and then hydrolysis with the value of ee 鈮?99.8%. In the experiment, the researchers used many compounds, for example, (S)-3-Methyl-1-(2-(piperidin-1-yl)phenyl)butan-1-amine (cas: 147769-93-5Formula: C16H26N2).

(S)-3-Methyl-1-(2-(piperidin-1-yl)phenyl)butan-1-amine (cas: 147769-93-5) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising 伪-glucosidase inhibitors. The former are analogs of DNJ with an improved 伪-glucosidase inhibitory profile than that of DNJ. Boisson et al.Formula: C16H26N2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Analyzing the synthesis route of 147769-93-5

147769-93-5, As the paragraph descriping shows that 147769-93-5 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.147769-93-5,(S)-3-Methyl-1-(2-(piperidin-1-yl)phenyl)butan-1-amine,as a common compound, the synthetic route is as follows.

EXAMPLE 1 Preparation of Ethyl (S)-2-ethoxy-4-[N-[1-(2-piperidinophenyl)-3-methyl-1-butyl]aminocarbonylmethyl]benzoate In a round bottom flask fitted with a dean stark condenser, (S)-3-methyl-1-(2-piperidinophenyl)-1-butylamine (10 g, 0.0406 mol) was dissolved in toluene (100 ml), followed by the addition of 3-ethoxy-4-ethoxycarbonyl phenyl acetic acid (10.26 g, 0.0407 mol) and boric acid (0.26 g, 0.0042 mol). The reaction mixture was refluxed for 16-18 hours. The resulting mass was then cooled to 25-30 C. followed by filtration. The filtrate was washed with water and 1.0% sodium bicarbonate solution followed by complete distillation of toluene and the resulting residue was stirred with hexane (50 ml) for 1 hour. The precipitated solid was filtered and washed with hexane (10 ml). The wet product was dried at 50-55 C. under vacuum for 4-6 hours to produce Ethyl (S)-2-ethoxy-4-[N-(1-(2-piperidino-phenyl)-3-methyl-1-butyl)-aminocarbonyl methyl]-benzoate (Yield=73.3%; HPLC Purity: 99.50%).

147769-93-5, As the paragraph descriping shows that 147769-93-5 is playing an increasingly important role.

Reference£º
Patent; ACTAVIS GROUP PTC hf; US2008/200684; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem