Category: 147539-41-1

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, category: piperidines, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 147539-41-1, Name is tert-Butyl 4-(methylamino)piperidine-1-carboxylate, molecular formula is C11H22N2O2. In a Article, authors is Andreev, Stanislav£¬once mentioned of 147539-41-1

Design, synthesis and biological evaluation of 7-chloro-9h-pyrimido[4,5-b]indole-based glycogen synthase kinase-3beta inhibitors

Glycogen synthase kinase-3beta (GSK-3beta) represents a relevant drug target for the treatment of neurodegenerative pathologies including Alzheimer?s disease. We herein report on the optimization of a novel class of GSK-3beta inhibitors based on the tofacitinib-derived screen hit 3-((3R,4R)-3-((7-chloro-9H-pyrimido[4,5-b]indol-4-yl)(methyl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile (1). We synthesized a series of 19 novel 7-chloro-9H-pyrimido[4,5-b]indole-based derivatives and studied their structure?activity relationships with focus on the cyanoacetyl piperidine moiety. We unveiled the crucial role of the nitrile group and its importance for the activity of this compound series. A successful rigidization approach afforded 3-(3aRS,7aSR)-(1-(7-chloro-9H-pyrimido[4,5-b]indol-4-yl)octahydro-6H-pyrrolo[2,3-c]pyridin-6-yl)-propanenitrile (24), which displayed an IC50 value of 130 nM on GSK-3beta and was further characterized by its metabolic stability. Finally, we disclosed the putative binding modes of the most potent inhibitors within the ATP binding site of GSK-3beta by 1 mus molecular dynamics simulations.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 147539-41-1, help many people in the next few years.category: piperidines

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H17203N – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. Quality Control of: tert-Butyl 4-(methylamino)piperidine-1-carboxylate. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 147539-41-1

Substituted Benzamide Compounds

Substituted benzamide compounds corresponding to formula (I) in which R5, R6, R7, R8, a, b, c, d, t, D and X have defined meanings, a process for their preparation, pharmaceutical compositions comprising such compounds, and a method of using such compounds to treat pain and other conditions mediated at least in part via the bradykinin 1 receptor.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Quality Control of: tert-Butyl 4-(methylamino)piperidine-1-carboxylate, you can also check out more blogs about147539-41-1

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H17189N – PubChem

 

147539-41-1, Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬Which mentioned a new discovery about 147539-41-1

A kind of quinazoline derivatives, its composition and use thereof (by machine translation)

The invention relates to the general formula I shown in the quinazoline derivatives, its composition and their use as PGK1 inhibitor in the preparation of anti-tumor drug use and in treating the malignant tumor in the use thereof. (by machine translation)

147539-41-1, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 147539-41-1

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Piperidine – Wikipedia,
Piperidine | C5H17171N – PubChem

 

147539-41-1, tert-Butyl 4-(methylamino)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of Cbz-protected tert-leucine (500 mg, 1.9 mmol) in dichloromethane (10 ml) was added PyAOP (1. 08 g, 2.1 mmol), HOAt (26 mg, 0. 19 mmol), triethylamine and 4-Methylamino-piperidine-1-carboxylic acid tert-butyl ester (606 mg, 2.8 mmol). The reaction mixture was stirred for 18 h at Rt. The solvent was removed in vacuo and the yellow residue was redissolved in dichloromethane (80 ml) and was washed with 1 M hydrochloric acid (2 x 80 ml), 1 M sodium carbonate (2 x 80 ml), brine (1 x 80 mi) and dried over anhydrous magnesium sulphate to yield a clear oil (2 g). Flash chromatography (2percent MeOH, dichloromethane) yielded the title compound as a white foam (870 mg, 100percent) which contained a slight impurity. HPLC. 6.9 min (85percent); LRMS: +ve ion 462 (M+1, 5percent), 484 (M+Na, 20percent). The compound was progressed to the next step without any further purification.

147539-41-1, 147539-41-1 tert-Butyl 4-(methylamino)piperidine-1-carboxylate 15380702, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; BRITISH BIOTECH PHARMACEUTICALS LTD; WO2003/89412; (2003); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

147539-41-1, tert-Butyl 4-(methylamino)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 191a4-Methylamino-piperidine-l-carboxylic acid tert-butyl ester (500 mg, 1.87 mmol) was suspended in 10 ml of 1,2-dichloroethane. Tetrahydro-pyran-4-one (0.17 ml, 1.87 mmol) was added and the reaction mixture was stirred at room temperature for 30 min. Sodium triacetoxyborohydride (593 mg, 2.80 mol) was added and the reaction mixture was stirred for 18 h. The reaction mixture was diluted with dichloromethane and washed with an aqueous saturated sodium bicarbonate solution.The organic phase was dried over sodium sulfate and concentrated under vacuum. The crude product was purified by flash chromatography (Isolute silica gel cartridge 1Og; eluent: dichloromethane/methanol=94/6percent). 240 mg (0.80 mmol) of the desired compound were obtained., 147539-41-1

As the paragraph descriping shows that 147539-41-1 is playing an increasingly important role.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; EBEL, Heiner; FRATTINI, Sara; GIOVANNINI, Riccardo; HOENKE, Christoph; TRIESELMANN, Thomas; TIELMANN, Patrick; SCHEUERER, Stefan; HOBBIE, Silke (Marie Katrin); WO2010/70032; (2010); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem