Category: 146093-46-1

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.146093-46-1,4-(Aminoethyl)-1-N-Boc-piperidine,as a common compound, the synthetic route is as follows.

EXAMPLE 12 A mixture of 3-ethoxycarbonyl-5-(4-cyanophenyl)-1,2,4-oxadiazole (2.0 g) and 2-(1-tert-butoxycarbonylpiperidin-4-yl)ethylamine in N,N-dimethylformamide (1 ml) was heated at 120 C. for 5 hours. The mixture was dissolved with ethyl acetate, washed with water, brine, dried over magnesium sulfate and evaporated in vacuo. The residue was recrystallized from ethanol to afford 3-[{2-(1-tert-butoxycarbonylpiperidin-4-yl)ethyl}carbamoyl]-5-(4-cyanophenyl)-1,2,4-oxadiazole (2.6 g). mp: 138-139 C. IR (Nujol): 3260, 2230, 1685 cm-1 NMR (DMSO-d6, delta): 1.00-1.07 (2H, m), 1.39 (9H, s), 1.46-1.48 (3H, m), 1.66-1.71 (2H, m), 2.65-2.68 (2H, m), 3.32-3.34 (2H, m), 3.89-3.95 (2H, m), 8.14 (2H, d, J=8.4 Hz), 8.31 (2H, d, J=8.4 Hz), 9.10-9.16 (1H, m) Elemental Analysis Calcd. for C22 H27 N5 O4: C 62.10, H 6.39, N 16.45 Found: C 61.84, H 6.42, N 16.23

146093-46-1, As the paragraph descriping shows that 146093-46-1 is playing an increasingly important role.

Reference£º
Patent; Fujisawa Pharmaceutical Co., Ltd.; US5622976; (1997); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

146093-46-1, 4-(Aminoethyl)-1-N-Boc-piperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

146093-46-1, Example 14 (compound No. 234)2,2,2-Trifluoro-1 -(trifluoromethyl)ethyl 4-[2-(5-carbamoylpyrazin-2-ylamino)ethyl]piperidine- 1 -carboxylate14.1 . ie f-Butyl 4-[2-(5-carbamoylpyrazin-2-ylamino)ethyl]piperidine-1 -carboxylate; A mixture of 1.12 g (7.15 mmol) of 5-chloropyrazine-2-carboxamide, 1.95 g (8.58 mmol) of ie f-butyl 4-(2-aminoethyl)piperidine-1 -carboxylate and 1 .18 g (8.58 mmol) of potassium carbonate in 1 .4 ml of dimethyl sulphoxide is heated during 5 hours at 100C under an argon atmosphere and with stirring. After cooling to ambient temperature, 25 ml of ethyl acetate and 25 ml of water are added. The organic phase is separated by settling and washed 3 times with 25 ml of water and then 25 ml of a saturated aqueous sodium chloride solution. It is dried over sodium sulphate and evaporated to dryness. The residue is purified by chromatography on silica gel, elution being carried out with a 97:3, then 95:5 and 93:7 mixture of dichloromethane and methanol, in order to obtain 1 .99 g (5.69 mmol) of product in the form of a light-yellow paste.1H NMR (CDCI3, delta ppm, 200 MHz): 8.65 (s, 1 H), 8.10 (s, 1 H), 7.55 (m, 1 H), 5.75 (m, 1 H), 4.85 (m, 1 H), 4.15 (m, 2H), 3.45 (m, 2H), 2.75 (t, 2H), 1 .80-1 .60 (m, 5H), 1 .50 (s, 9H), 1 .35-1 .10 (m, 2H).

As the paragraph descriping shows that 146093-46-1 is playing an increasingly important role.

Reference£º
Patent; SANOFI; BARTSCH, Regine; CHEURET, Dorothee; EVEN, Luc; HOORNAERT, Christian; JEUNESSE, Jean; MARGUET, Frank; WO2011/151808; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.146093-46-1,4-(Aminoethyl)-1-N-Boc-piperidine,as a common compound, the synthetic route is as follows.

To a solution of 2-(4-oxo-3,4-dihydropyrido[3,4-d]pyrimidin-2-yl)benzofuran-7- carboxylic acid (1.0 eq) and 4-(2-Amino-ethyl)-piperidine-l -carboxylic acid tert-butyl ester (1.1 eq) in Nu,Nu-dimethylformamide were added N,N-diisopropylethylamine (2.0 eq) and HATU (1.2 eq). The mixture was allowed to stir for 30 min. It was diluted with brine and extracted with ethyl’ acetate twice. The combined organic extract was washed with brine twice and dried over magnesium sulfate (or extracted with UCT SPE CUBCX -cartr-idge)r4t- was concentrated- and- purified by combi-flashr~or~preparative^ HPLC., 146093-46-1

As the paragraph descriping shows that 146093-46-1 is playing an increasingly important role.

Reference£º
Patent; DONG-A SOCIO HOLDINGS CO., LTD.; KIM, Myeong-seop; PARK, Taesun; YOON, Taeyoung; YANG, Seung Min; KIM, Hae-Sun; KIM, Jun Gyu; (285 pag.)WO2016/68580; (2016); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

146093-46-1, 4-(Aminoethyl)-1-N-Boc-piperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1 : fert-Butyl 4-(2-(dinony lamino)ethyl)piperi dine- 1-carboxy late Chemical Formula: C30H60N2O2 (2256) Molecular Weight: 480.82 (2257) [00714] a mixture of fert-butyl 4-(2-aminoethyl)piperi dine- 1 -carboxy late (1.50 g, 6.6 mmol) and 1 -bromononane (1.36 g, 6.57 mmol) in MeCN (100 mL) was added K2CO3 (1.83 g, (2258) 13.1 mmol) and KI (109 mg, 0.66 mmol) and the mixture was allowed to stir at 82 C for 12 hours. The suspension was cooled to RT, filtered over a pad of celite rinsing with hexanes, and concentrated in vacuo. Purification by ISCO silica flash chromatography (0-100% DCM/[DCM 20% MeOH 1%) NH4OH]) provided tot-butyl 4-(2-(dinonylamino)ethyl)piperidine-l – carboxylate (602 mg, 19%). (2259) UPLC/ELSD: RT = 2.41 min. MS (ES): m/z (MH+) 482 for C3oH6oN202 (2260) Ti-NMR (300 MHz, CDC13) delta: ppm 4.20-2.26 (br. m, 10H); 1.77-1.10 (br. m, 44H); 0.91 (t, (2261) 6H).

146093-46-1, The synthetic route of 146093-46-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MODERNATX, INC.; BENENATO, Kerry E.; BUTCHER, William; (437 pag.)WO2017/112865; (2017); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

146093-46-1, 4-(Aminoethyl)-1-N-Boc-piperidine is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

G.i. 7-((2-(l-(tert-butoxycarbonyl)piperidin-4-yl)ethyl)amino)-l-cyclopropyl-6-fluoro-4-oxo- 1, 4-dihydro-l,8-naphthyridine-3-carboxylic acid: Starting from 7-chloro- 1 -cyclopropyl-6-fluoro- 1 ,4-dihydro-4-oxo- 1 ,8-naphthyridine-3- carboxylic acid (311 mg; CAS 100361-18-0; commercial) and 4-(2-aminoethyl)-l- piperidinecarboxylic acid tert-butyl ester (194 mg; CAS 146093-46-1; commercial) and proceeding in analogy to preparation A, step A.ii, the title compound was obtained as a colorless solid (240 mg; 46% yield). MSI (ESI, m/z): 475.27 [M+H+]; tR = 0.95 min., 146093-46-1

146093-46-1 4-(Aminoethyl)-1-N-Boc-piperidine 1514258, apiperidines compound, is more and more widely used in various.

Reference£º
Patent; ACTELION PHARMACEUTICALS LTD; ENDERLIN-PAPUT, Stephanie; HUBSCHWERLEN, Christian; RUEEDI, Georg; ZUMBRUNN, Cornelia; WO2014/178008; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem