Category: 145166-06-9

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: tert-Butyl ((1S,2S)-2-hydroxycyclohexyl)carbamate(SMILESS: O=C(OC(C)(C)C)N[C@@H]1[C@@H](O)CCCC1,cas:145166-06-9) is researched.Computed Properties of C3H4Br2O2. The article 《Highly enantioselective direct organocatalytic α-chlorination of ketones》 in relation to this compound, is published in Angewandte Chemie, International Edition. Let’s take a look at the latest research on this compound (cas:145166-06-9).

A C2-sym. diamine I served as the organocatalyst in an asym. α-chlorination reaction of simple ketones. Optically active α-chloro ketones were formed with excellent enantioselectivities using N-chlorosuccinimide (NCS) as the chlorine source. These products have broad synthetic utility, in particular for pharmaceutical applications.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Safety of tert-Butyl ((1S,2S)-2-hydroxycyclohexyl)carbamate. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: tert-Butyl ((1S,2S)-2-hydroxycyclohexyl)carbamate, is researched, Molecular C11H21NO3, CAS is 145166-06-9, about Discovery and structure-activity relationships of 4-aminoquinazoline derivatives, a novel class of opioid receptor like-1 (ORL1) antagonists.

Synthesis and structure-activity relationship studies of a series of 4-aminoquinazoline derivatives led to the identification of (1 R,2 S)-17, N-[(1R,2S)-2-({2-[(4-chlorophenyl)carbonyl]amino-6-methylquinazolin-4-yl}amino)cyclohexyl]guanidine dihydrochloride, as a highly potent ORL1 antagonist with up to 3000-fold selectivity over the μ, δ, and κ opioid receptors. Mol. modeling clarified the structural factors contributing to the high affinity and selectivity of (1 R,2 S)-17.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Safety of tert-Butyl ((1S,2S)-2-hydroxycyclohexyl)carbamate. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: tert-Butyl ((1S,2S)-2-hydroxycyclohexyl)carbamate, is researched, Molecular C11H21NO3, CAS is 145166-06-9, about Enzymatic method of preparation of optically active trans-2-amino cyclohexanol derivatives. Author is Ursini, A.; Maragni, P.; Bismara, C.; Tamburini, B..

Supported Lipase Amano PS-D catalyzes the resolution of (±)-trans-2-[(tert-butoxycarbonyl)amino]cyclohexanol by a selective acylation reaction. Using the supported enzyme gave a much faster reaction compared to existing methodol. on similar substrates. A variety of acylating agents were investigated, with vinyl acetate providing the most practical and convenient procedure.

Different reactions of this compound(tert-Butyl ((1S,2S)-2-hydroxycyclohexyl)carbamate)Safety of tert-Butyl ((1S,2S)-2-hydroxycyclohexyl)carbamate require different conditions, so the reaction conditions are very important.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Qiao, Jennifer X.; Chang, Chong-Hwan; Cheney, Daniel L.; Morin, Paul E.; Wang, Gren Z.; King, Sarah R.; Wang, Tammy C.; Rendina, Alan R.; Luettgen, Joseph M.; Knabb, Robert M.; Wexler, Ruth R.; Lam, Patrick Y. S. researched the compound: tert-Butyl ((1S,2S)-2-hydroxycyclohexyl)carbamate( cas:145166-06-9 ).SDS of cas: 145166-06-9.They published the article 《SAR and X-ray structures of enantiopure 1,2-cis-(1R,2S)-cyclopentyldiamine and cyclohexyldiamine derivatives as inhibitors of coagulation Factor Xa》 about this compound( cas:145166-06-9 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: Factor Xa selective inhibitor SAR bisacylaminocycloalkane preparation anticoagulant; crystal structure bisacylaminoethane bisacylaminocycloalkane Factor Xa complex; mol structure bisacylaminoethane bisacylaminocycloalkane Factor Xa complex; acylaminocyclopentane Factor Xa selective inhibitor SAR preparation anticoagulant; acylaminocyclohexane Factor Xa selective inhibitor SAR preparation anticoagulant. We’ll tell you more about this compound (cas:145166-06-9).

In the search of Factor Xa (FXa) inhibitors structurally different from the pyrazole-based series, the authors identified a viable series of enantiopure cis-(1R,2S)-bis(acylamino)cycloalkanes as potent and selective inhibitors of FXa. Among them, I and II were the most potent neutral compounds, and had good anticoagulant activity comparable to the pyrazole-based analogs. Crystal structures of I-FXa and II-FXa illustrate binding similarities and differences between the five- and the six-membered core systems, and provide rationales for the observed SAR of P1 and linker moieties G and Z in III (n = 1, 2).

The article 《SAR and X-ray structures of enantiopure 1,2-cis-(1R,2S)-cyclopentyldiamine and cyclohexyldiamine derivatives as inhibitors of coagulation Factor Xa》 also mentions many details about this compound(145166-06-9)SDS of cas: 145166-06-9, you can pay attention to it or contacet with the author([email protected]) to get more information.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Safety of tert-Butyl ((1S,2S)-2-hydroxycyclohexyl)carbamate. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: tert-Butyl ((1S,2S)-2-hydroxycyclohexyl)carbamate, is researched, Molecular C11H21NO3, CAS is 145166-06-9, about Study of stereomeric peptoid chiral stationary phases containing different chiral side chains. Author is Wu, Haibo; Song, Guangjun; Wang, Dongqiang; Yu, Hui; Ke, Yanxiong; Liang, Xinmiao.

The authors studied six stereomeric peptoid chiral stationary phases (CSPs) successively combining N’-phenyl-proline amide, α-phenylethyl amine, 2-aminocyclohexyl phenylcarbamate and another α-phenylethyl amine under normal phase mode. CSPs 1-4, I, with R-S-(1R,2R)-S, R-S-(1S,2S)-S, R-R-(1R,2R)-R and R-R-(1S,2S)-R configuration exhibited much different enantiorecognition abilities. Overall, CSPs 1 and 2 performed better for the 55 analytes tested. CSP 5 (I, R-S-rac-S) with mixed selectors combined partial selectivities of CSPs 1 and 2. CSP 6 (I, S-R-(1R,2R)-R) as enantiomeric counterpart of CSP 2 exhibited similar enantioseparation ability and reversal elution orders for analytes resolved. For several biaryl type analytes, CSP 6 even outperformed com. Chiralpak AD-H and Chiralcel OD-H. Excellent resolution of 3,3′-diphenyl-2,2′-bi-1-naphthalol (VANOL) on CSP 6 illustrated its potential application in preparative enantioseparation Eluting orders of enantiomers on stereomeric CSPs also provided the authors further insight into enantiorecognition of some analytes.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 145166-06-9, is researched, Molecular C11H21NO3, about Cycloalkanediamine derivatives as novel blood coagulation factor Xa inhibitors, the main research direction is cycloalkanediamine sulfonyl carbonyl preparation blood coagulation factor Xa inhibitor; indolyl thiazolopyridyl cycloalkanediamine preparation blood coagulation factor Xa inhibitor.Application In Synthesis of tert-Butyl ((1S,2S)-2-hydroxycyclohexyl)carbamate.

This paper describes the synthesis of orally available potent fXa inhibitors, e.g. cis – or trans-I (X = SO2, CO) by modification of the piperazine part of the lead compound The carbonyl derivatives showed potent fXa activity but not the sulfonyl derivatives Among the compounds synthesized, cyclohexane derivatives and cycloheptane derivatives had potent anticoagulant activity as well as anti-fXa activity. Synthetic study of the optical isomers demonstrated that the (-)-(1R,2S)-isomer (I, X = CO) had more potent activity.

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Piperidine – Wikipedia,
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Electric Literature of C11H21NO3. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: tert-Butyl ((1S,2S)-2-hydroxycyclohexyl)carbamate, is researched, Molecular C11H21NO3, CAS is 145166-06-9, about Chemoenzymatic preparation of optically active trans- and cis-cyclohex-4-ene-1,2-diamine and trans-6-aminocyclohex-3-enol derivatives. Author is Quijada, F. Javier; Rebolledo, Francisca; Gotor, Vicente.

Lipase from Burkholderia cepacia effectively catalyzed the kinetic resolution of both racemic trans-N,N-diallylcyclohex-4-ene-1,2-diamine and its precursor trans-6-(diallylamino)cyclohex-3-enol. The resulting optically active vicinal diamine and β-amino alc. were converted into a precursor of oseltamivir and a cis-cyclohex-4-ene-1,2-diamine derivative, resp.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Computed Properties of C11H21NO3. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: tert-Butyl ((1S,2S)-2-hydroxycyclohexyl)carbamate, is researched, Molecular C11H21NO3, CAS is 145166-06-9, about Synthesis of enantiopure N-tert-butoxycarbonyl-2-aminocycloalkanones.

A route to enantiomerically pure N-tert-butoxycarbonyl-2-aminocycloalkanones I (n = 1-4) from the corresponding cycloalkene oxides is described. The procedure involves (1) aminolysis of the cycloalkene oxides with (S)-α-methylbenzylamine/Me3Al and chromatog. separation of diastereomers, (2) hydrogenolysis to afford the trans-2-aminocycloalkanols II, (3) tert-butoxycarbonyl protection, and (4) PCC oxidation

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Reference:
Piperidine – Wikipedia,
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Recommanded Product: tert-Butyl ((1S,2S)-2-hydroxycyclohexyl)carbamate. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: tert-Butyl ((1S,2S)-2-hydroxycyclohexyl)carbamate, is researched, Molecular C11H21NO3, CAS is 145166-06-9, about Synthesis and Evaluation of (1S,2R/1R,2S)-Aminocyclohexylglycyl PNAs as Conformationally Preorganized PNA Analogues for DNA/RNA Recognition. Author is Govindaraju, T.; Kumar, Vaijayanti A.; Ganesh, Krishna N..

Conformationally constrained cis-aminocyclohexylglycyl PNAs (peptide nucleic acids) have been designed on the basis of stereospecific imposition of 1,2-cis-cyclohexyl moieties on the aminoethyl segment of aminoethylglycyl PNA (aegPNA). The introduction of the cis-cyclohexyl ring may allow the restriction of the torsion angle β in the ethylenediamine segment to 60-70° that is prevalent in PNA2:DNA and PNA:RNA complexes. The synthesis of the optically pure monomers, thyminyl derivatives (1S,2R)-I and (1R,2S)-II, is achieved by stereoselective enzymic hydrolysis of an intermediate ester, trans-2-azidocyclohexyl butanoate. The chiral PNA oligomers were synthesized with I and II in the center and N-terminus of aegPNA. Differential gel shift retardation with one or more units of modified monomer units was observed as a result of hybridization of PNA sequences with complementary DNA sequences. Hybridization studies with complementary DNA and RNA sequences using UV-Tm measurements indicate that PNA with (1S,2R)-cyclohexyl stereochem. enhances selective binding with RNA over DNA as compared to control aegPNA and PNA with the other (1R,2S) isomer.

There is still a lot of research devoted to this compound(SMILES：O=C(OC(C)(C)C)N[C@@H]1[C@@H](O)CCCC1)Recommanded Product: tert-Butyl ((1S,2S)-2-hydroxycyclohexyl)carbamate, and with the development of science, more effects of this compound(145166-06-9) can be discovered.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem