Category: 1445-73-4

In 2019,European Journal of Medicinal Chemistry included an article by Uprety, Rajendra; Varadi, Andras; Allaoa, Abdullah; Redel-Traub, Gabriel N.; Palmer, Travis C.; Feinberg, Evan N.; Ferris, Alex C.; Pande, Vijay S.; Pasternak, Gavril W.; Majumdar, Susruta. Synthetic Route of C6H11NO. The article was titled 《Synthesis of spiro-2,6-dioxopiperazine and spiro-2,6-dioxopyrazine scaffolds using amino acids in a three-component reaction to generate potential Sigma-1 (σ1) receptor selective ligands》. The information in the text is summarized as follows:

The design and synthesis of novel heterocycles with spiro-2,6-dioxopiperazine and spiro-2,6-pyrazine scaffolds through a three-component reaction using various amino acids, ketones and isocyanides was presented. Screening of selected compounds over fifty CNS receptors including G-protein coupled receptors (GPCRs), ion channels, transporters and enzymes through the NIMH psychoactive drug screening program indicated that a novel spiro-2,6-dioxopyrazine scaffold, e.g., I, displayed high binding affinity at sigma-1 (σ1) receptor in the nanomolar range. In addition, mol. docking of spiro-2,6-dioxopyrazine scaffold, e.g., I at the human σ1 receptor showed that it resides in the same binding site that was occupied by the ligand N-(N-benzylpiperidin-4-yl)-4-iodobenzamide (4-IBP) used to obtain a crystal structure of the human sigma-1 (σ1) receptor. In the experiment, the researchers used 1-Methyl-4-piperidone(cas: 1445-73-4Synthetic Route of C6H11NO)

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.Synthetic Route of C6H11NO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

《Site-selective α-C-H Functionalization of Trialkylamines via Reversible HAT-Catalysis》 was written by Shen, Yangyang; Funez-Ardoiz, Ignacio; Schoenebeck, Franziska; Rovis, Tomislav. Formula: C6H11NOThis research focused ontrialkylamine regioselective functionalization reversible HAT catalysis. The article conveys some information:

Despite the recent breakthrough of catalytic alkylation of dialkylamines, the selective α-C(sp3)-H bond functionalization of widely available trialkylamine scaffolds holds promise to streamline complex trialkylamine synthesis, accelerate drug discovery and execute late-stage pharmaceutical modification with complementary reactivity. However, the canonical methods always result in functionalization at the less-crowded site. Herein, authors describe a solution to switch the reaction site through fundamentally overcoming the steric control that dominates such processes. By rapidly establishing an equilibrium between α-amino C(sp3)-H bonds and a highly electrophilic thiol radical via reversible hydrogen atom transfer, authors leverage a slower radical-trapping step with electron-deficient olefins to selectively forge a C(sp3)-C(sp3) bond with the more-crowded α-amino radical, with the overall selectivity guided by Curtin-Hammett principle. This subtle reaction profile has unlocked a new strategic concept in direct C-H functionalization arena for forging C-C bonds from a diverse set of trialkylamines with high levels of site-selectivity and preparative utility. The broad consequences of this dynamic system, together with the ability to forge N-substituted quaternary carbon centers and implement late-stage functionalization techniques, holds potential to streamline complex trialkylamine synthesis and accelerate small-mol. drug discovery. In the experiment, the researchers used 1-Methyl-4-piperidone(cas: 1445-73-4Formula: C6H11NO)

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.Formula: C6H11NO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

《A Novel Synthesis of Pimavanserin: A Selective Serotonin 5-HT2A Receptor Inverse Agonist》 was written by Hu, Kun; Zhang, Meiju; Wu, Dongdong; Xie, Yuxuan; Ren, Jie. Safety of 1-Methyl-4-piperidone And the article was included in Organic Preparations and Procedures International in 2020. The article conveys some information:

The title compound I was prepared using a novel, low-cost, high-yielding, and eco-friendly procedure starting from (4-hydroxyphenyl)acetic acid. The total yield of I for the 10-step process is 33%. The experimental part of the paper was very detailed, including the reaction process of 1-Methyl-4-piperidone(cas: 1445-73-4Safety of 1-Methyl-4-piperidone)

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine-containing compounds are also frequently employed in synthesis as ligands or auxiliaries. Accordingly, many efforts have been devoted to the development of novel methods for the synthesis of these compounds over the years.Safety of 1-Methyl-4-piperidone

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In 2019,Journal of Organometallic Chemistry included an article by Lahiji, Fatemeh Khadem; Ariafard, Alireza. Recommanded Product: 1-Methyl-4-piperidone. The article was titled 《Revisiting the mechanism of acetylenic amine N-Oxide rearrangement catalyzed by Gold(I) complexes from a DFT perspective》. The information in the text is summarized as follows:

In this study, we used d. functional theory (DFT) to reinvestigate the mechanism proposed by Houk and Zhang et al. (J. Am. Chem. Soc. 2012, 134, 1078) for piperidinone formation through rearrangement of an acetylenic amine N-oxide catalyzed by phosphine gold(I) complexes. For this rearrangement, the C-C coupling was proposed to be the rate-determining step with activation energy as high as 35.8 kcal/mol. Such a barrier seems inconsistent with the fact that the actual reaction proceeds under very mild conditions (0 °C, 1 h, in CH2Cl2). In the original report, it was proposed that the C-C coupling takes place via a mechanism which we called “”front-side addition””. Interestingly, we found that the C-C coupling step becomes energetically more favorable if it occurs via another mechanism called “”back-side addition””. We explored the effect of different phosphine ligands on all conceivable steps of the catalytic reaction and found that while the other steps are not highly sensitive to the phosphine identity, the C-C coupling one shows a considerable degree of dependency; the more electron-donating the phosphine ligand, the lower the rate-limiting step barrier. The experimental process involved the reaction of 1-Methyl-4-piperidone(cas: 1445-73-4Recommanded Product: 1-Methyl-4-piperidone)

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine-containing compounds are also frequently employed in synthesis as ligands or auxiliaries. Accordingly, many efforts have been devoted to the development of novel methods for the synthesis of these compounds over the years.Recommanded Product: 1-Methyl-4-piperidone

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

《Automated, Accelerated Nanoscale Synthesis of Iminopyrrolidines》 was written by Osipyan, Angelina; Shaabani, Shabnam; Warmerdam, Robert; Shishkina, Svitlana V.; Boltz, Harry; Doemling, Alexander. Recommanded Product: 1445-73-4 And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

Miniaturization and acceleration of synthetic chem. is an emerging area in pharmaceutical, agrochem., and materials research and development. Herein, we describe the synthesis of iminopyrrolidine-2-carboxylic acid derivatives using chiral glutamine, oxo components, and isocyanide building blocks in an unprecedented Ugi-3-component reaction. We used I-DOT, a pos.-pressure-based low-volume and non-contact dispensing technol. to prepare more than 1000 different derivatives in a fully automated fashion. In general, the reaction is stereoselective, proceeds in good yields, and tolerates a wide variety of functional groups. We exemplify a pipeline of fast and efficient nanomole-scale scouting to millimole-scale synthesis for the discovery of a useful novel reaction with great scope. In the part of experimental materials, we found many familiar compounds, such as 1-Methyl-4-piperidone(cas: 1445-73-4Recommanded Product: 1445-73-4)

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine-containing compounds are also frequently employed in synthesis as ligands or auxiliaries. Accordingly, many efforts have been devoted to the development of novel methods for the synthesis of these compounds over the years.Recommanded Product: 1445-73-4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Recommanded Product: 1-Methyl-4-piperidoneIn 2021 ,《Synthesis, Biological Evaluation, and Molecular Docking Studies of Some Spiro-5-Cyanopyrimidine Derivatives》 was published in Russian Journal of Bioorganic Chemistry. The article was written by Goda Pankaja Kumar; Sekhar, Thuraka; Thriveni, Pinnu; Venkateswarlu, Annavarapu; Peddanna, Kotha; Reddy, Peduri Suresh; Krishna, Mypati Hari; Sreelatha, Tumma. The article contains the following contents:

A simple, convenient, environmentally benign method has been developed for the synthesis of spiro-5-cyanopyrimidines by multi-component condensation of cyclic ketones, malononitrile and urea/thiourea using potassium carbonate in aqueous medium. The simple work-up procedure and good yield in short time are important features of this protocol. The synthesized compounds were tested for antibacterial activity against Gram pos. and Gram neg. bacteria and some of the tested compounds were found to have good antibacterial activities. Furthermore, docking study has been performed against enzyme of bacteria that showed good binding interactions. In the experiment, the researchers used 1-Methyl-4-piperidone(cas: 1445-73-4Recommanded Product: 1-Methyl-4-piperidone)

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.Recommanded Product: 1-Methyl-4-piperidone

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Kostrzewa, Tomasz; Wolosewicz, Karol; Jamrozik, Marek; Drzezdzon, Joanna; Sieminska, Julia; Jacewicz, Dagmara; Gorska-Ponikowska, Magdalena; Kolaczkowski, Marcin; Lazny, Ryszard; Kuban-Jankowska, Alicja published their research in International Journal of Molecular Sciences in 2021. The article was titled 《Curcumin and Its New Derivatives: Correlation between Cytotoxicity against Breast Cancer Cell Lines, Degradation of PTP1B Phosphatase and ROS Generation》.Recommanded Product: 1-Methyl-4-piperidone The article contains the following contents:

Breast cancer is the most common cancer of women-it affects more than 2 million women worldwide. PTP1B phosphatase can be one of the possible targets for new drugs in breast cancer therapy. In this paper, we present new curcumin derivatives featuring a 4-piperidone ring as PTP1B inhibitors and ROS inducers. We performed cytotoxicity anal. for twelve curcumin derivatives against breast cancer MCF-7 and MDA-MB-231 cell lines and the human keratinocyte HaCaT cell line. Furthermore, because curcumin is a known antioxidant, we assessed antioxidant effects in its derivatives For the most potent cytotoxic compounds, we determined intracellular ROS and PTP1B phosphatase levels. Moreover, for curcumin and its derivatives, we performed real-time microscopy to observe the photosensitizing effect. Finally, computational anal. was performed for the curcumin derivatives with an inhibitory effect against PTP1B phosphatase to assess the potential binding mode of new inhibitors within the allosteric site of the enzyme. We observed that two tested compounds are better anticancer agents than curcumin. Moreover, we suggest that blocking the -OH group in phenolic compounds causes an increase in the cytotoxicity effect, even at a low concentration Furthermore, due to this modification, a higher level of ROS is induced, which correlates with a lower level of PTP1B. The results came from multiple reactions, including the reaction of 1-Methyl-4-piperidone(cas: 1445-73-4Recommanded Product: 1-Methyl-4-piperidone)

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.Recommanded Product: 1-Methyl-4-piperidone

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Sharma, Jeet; Misra, S. K.; Kulshrestha, Vaibhav published an article in 2021. The article was titled 《Internally crosslinked poly(2,6-dimethyl-1,4-phenylene ether) based anion exchange membrane for recovery of different acids by diffusion dialysis》, and you may find the article in Chemical Engineering Journal (Amsterdam, Netherlands).Safety of 1-Methyl-4-piperidone The information in the text is summarized as follows:

Acid recovery from acidic waste is a critical issue to be focused on nowadays. Chem. approaches for recovery are not com. viable and energy intensive to save the environment. Here, we report internally crosslinked poly (2,6-dimethyl-1,4-phenylene ether) (PPE) based anion exchange membranes (AEMs) for acid recovery by diffusion dialysis, prepared via quick grafting of N-methyl-4-piperidone using ultrasonication. The prepared AEMs are assessed for their physicochem. parameters and depicted water uptake (WU) and ion-exchange capacity (IEC) in the range 22.00%-31.00% and 0.64 meq/g-2.18 meq/g resp. for Cl-1, NO-3 and SO2-4 ions. AEMs were investigated for recovery of hydrochloric acid (HCl), nitric acid (HNO3) and sulfuric acid (H2SO4) from simulated effluent based on their proton diffusion coefficient (U+H), separation factor (S) and recovery efficiency. These membranes illustrated the proton diffusion coefficient as high as 0.065 m h-1 and enhanced separation factor values up to 132 at 27°C. Recovery performance for different acids is corroborated based on unique self-organized membrane structure, studied using AFM phase imaging and cumulative influence of bulk diffusion coefficient, ion-exchange capacity, and hydration radii of Cl-1, NO-3 and SO2-4 ions. The acid recovery efficiency illustrated the trend HCl > HNO3 > H2SO4. The hydrate (-OH) functionality with a non-overlapping set of lone pairs on oxygen enhances the proton mobility via Grotthuss mechanism inside the membrane matrix and provides a cradle-like pathway for high proton mobility. The results are pronounced for fabricated membranes compared to com. available standards for acid recovery via diffusion dialysis. In addition to this study using 1-Methyl-4-piperidone, there are many other studies that have used 1-Methyl-4-piperidone(cas: 1445-73-4Safety of 1-Methyl-4-piperidone) was used in this study.

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.Safety of 1-Methyl-4-piperidone

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

The author of 《Potential multifunctional agents with anti-hepatoma and anti-inflammation properties by inhibiting NF-κB activation》 were Su, Chang-Ming; Hou, Gui-Ge; Wang, Chun-Hua; Zhang, Hong-Qin; Yang, Cheng; Liu, Mei; Hou, Yun. And the article was published in Journal of Enzyme Inhibition and Medicinal Chemistry in 2019. Synthetic Route of C6H11NO The author mentioned the following in the article:

Inhibition of NF-κB signalling has been demonstrated as a therapeutic option in treating inflammatory diseases and cancers. Herein, we synthesized novel dissym. 3,5-bis(arylidene)-4-piperidones (BAPs, 83-102 ) and characterized fully. MTT and ELISA assay were performed to screen the anti-hepatoma and anti-inflammation properties. 96(I) showed the most potential bioactivity. I could promote HepG2 apoptosis through up-regulating the expression of C-Caspase-3 and Bax, down-regulating the expression of Bcl-2, while markedly inhibit LPS or TNF-α-induced activation of NF-κB through both inhibiting the phosphorylation of IκBα and p65, and preventing the p65 nuclear translocation to exhibit both anti-hepatoma and anti-inflammatory activities. Mol. docking verified that simulated I can effectively bond to the active site of Bcl-2 and NF-κB/p65 proteins. I inhibited xenografts growth by reducing the expression of TNF-α and Bcl-2 in the tumor tissue. This study suggested that I could be developed as a potential multifunctional agent for treatment of inflammatory diseases and cancers. The results came from multiple reactions, including the reaction of 1-Methyl-4-piperidone(cas: 1445-73-4Synthetic Route of C6H11NO)

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.Synthetic Route of C6H11NO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In 2022,Liu, Xiaoxiao; Wei, Wei; Yang, Yunfei; Li, Yujiao; Li, Yao; Xu, Shicheng; Dong, Yanfeng; He, Ronghuan published an article in Chemical Engineering Journal (Amsterdam, Netherlands). The title of the article was 《A porous membrane electrolyte enabled by poly(biphenyl piperidinium triphenylmethane) for dendrite-free zinc anode with enhanced cycling life》.Product Details of 1445-73-4 The author mentioned the following in the article:

Aqueous zinc-ion batteries show great advantages as the sustainable energy storage devices, but suffer from inferior cycling life and low energy d. due to the notorious zinc dendrites and possible side reactions in aqueous electrolytes. Herein, we propose a zinc-ions (Zn2+) soaked porous membrane electrolyte (GF/PBPT) by incorporating poly(biphenyl piperidinium triphenylmethane) (PBPT) into glass fiber (GF) via non-solvent-induced phase separation The PBPT was synthesized via a super-acid catalyzed polymerization reaction. The fabricated membrane electrolyte containing PBPT of 42 wt% (GF/PBPT-42%) exhibits suitable pores and reasonable mech. robustness of 4.24 MPa. Moreover, the abundant tertiary amines on PBPT backbones have specific affinity to Zn2+, which benefits the uniform Zn2+ flux through the membrane electrolyte. As a result, the electrolyte of GF/PBPT-42% greatly facilitates dendrite-free Zn anode and enables the Zn/Zn cell to deliver a superior cycling life over 1540 h at 0.5 mA cm-2 at room temperature (RT). In addition to be used in the Zn/Zn cells, the GF/PBPT-42% membrane has been demonstrated its application as the electrolyte in the Zn/MnO2 cell with enhanced cycling stability at both RT and -10 °C. In the experiment, the researchers used many compounds, for example, 1-Methyl-4-piperidone(cas: 1445-73-4Product Details of 1445-73-4)

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.Product Details of 1445-73-4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem