Category: 1445-73-4

In 2022,Wang, Chang; Qu, Lunjun; Chen, Xiaohong; Zhou, Qian; Yang, Yan; Zheng, Yan; Zheng, Xian; Gao, Liang; Hao, Jinqiu; Zhu, Lingyun; Pi, Bingxue; Yang, Chaolong published an article in Advanced Materials (Weinheim, Germany). The title of the article was 《Poly(arylene piperidine) Quaternary Ammonium Salts Promoting Stable Long-Lived Room-Temperature Phosphorescence in Aqueous Environment》.SDS of cas: 1445-73-4 The author mentioned the following in the article:

Room-temperature phosphorescence (RTP) materials have garnered considerable research attention owing to their excellent luminescence properties and potential application prospects in anti-counterfeiting, information storage, and optoelectronics. However, several RTP systems are extremely sensitive to humidity, and consequently, the realization of long-lived RTP in water remains a formidable challenge. Herein, a feasible and effective strategy is presented to achieve long-lived polymeric RTP systems, even in an aqueous environment, through doping of synthesized polymeric phosphor PBHDB into a poly(Me methacrylate) (PMMA) matrix. Compared to the precursor polymer PBN and organic mol. HDBP, a more rigid polymer microenvironment and electrostatic interaction are formed between the PMMA matrix and polymer PBHDB, which effectively reduce the nonradiative decay rate of triplet excitons and dramatically increase the phosphorescence intensity. Specifically, the phosphorescence lifetime of the PBHDB@PMMA film (1258.62 ms) is much longer than those of PBN@PMMA (674.20 ms) and HDBP@PMMA (1.06 ms). Most importantly, a bright-green afterglow can be observed after soaking the PBHDB@PMMA film in water for more than a month. The excellent water resistance and reversible response properties endow these systems with promising potential for dynamic information encryption even in water.1-Methyl-4-piperidone(cas: 1445-73-4SDS of cas: 1445-73-4) was used in this study.

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.SDS of cas: 1445-73-4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Misal Castro, Luis C.; Sultan, Ibrahim; Nishi, Kohei; Tsurugi, Hayato; Mashima, Kazushi published their research in Journal of Organic Chemistry in 2021. The article was titled 《Direct Synthesis of Indoles from Azoarenes and Ketones with Bis(neopentylglycolato)diboron Using 4,4′-Bipyridyl as an Organocatalyst》.Safety of 1-Methyl-4-piperidone The article contains the following contents:

Multifunctionalized indole derivatives were prepared by reducing azoarenes in the presence of ketones and bis(neopentylglycolato)diboron (B2nep2) with a catalytic amount of 4,4′-bipyridyl under neutral reaction conditions, where 4,4′-bipyridyl acted as an organocatalyst to activate the B-B bond of B2nep2 and form N,N’-diboryl-1,2-diarylhydrazines as a key intermediate. Further reaction of N,N’-diboryl-1,2-diarylhydrazines with ketones afforded N-vinyl-1,2-diarylhydrazines, which rearranged to the corresponding indoles via the Fischer indole mechanism. This organocatalytic system was applied to diverse alkyl cyclic ketones, dialkyl, and alkyl/aryl ketones, including heteroatoms. Me alkyl ketones gave the corresponding 2-methyl-3-substituted indoles in a regioselective manner. This protocol allowed us to expand the preparation of indoles having high compatibility with not only electron-donating and electron-withdrawing groups but also N- and O-protecting functional groups. In the part of experimental materials, we found many familiar compounds, such as 1-Methyl-4-piperidone(cas: 1445-73-4Safety of 1-Methyl-4-piperidone)

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.Safety of 1-Methyl-4-piperidone

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

《Design, synthesis and biological activities of piperidine-spirooxadiazole derivatives as α7 nicotinic receptor antagonists》 was published in European Journal of Medicinal Chemistry in 2020. These research results belong to Zhang, Han; He, Xiaomeng; Wang, Xintong; Yu, Bo; Zhao, Siqi; Jiao, Peili; Jin, Hongwei; Liu, Zhenming; Wang, KeWei; Zhang, Liangren; Zhang, Lihe. Category: piperidines The article mentions the following:

7 Nicotinic acetylcholine receptors (nAChRs) expressed in the nervous and immune systems was suggested to play important roles in the control of inflammation. However, the lack of antagonist tools specifically inhibiting α7 nAChR impedes the validation of the channel as therapeutic target. To discover a selective α7 antagonist, a pharmacophore-based virtual screening and identified a piperidine-spirooxadiazole derivative T761-0184 that acts as a α7 antagonist. A series of novel piperidine-spirooxadiazole derivatives were subsequently synthesized and evaluated using two-electrode voltage clamp (TEVC) assay in Xenopus oocytes. Lead compounds from two series inhibited α7 with their IC50 values ranging from 3.3μM to 13.7μM. Compound 3-(4-Bromophenyl)-8-methyl-1-oxa-2,4,8-triazaspiro[4.5]dec-2-ene exhibited α7 selectivity over other α4β2 and α3β4 nAChR subtypes. The anal. of structure-activity relationship (SAR) provides valuable insights for further development of selective α7 nAChR antagonists. In the experiment, the researchers used 1-Methyl-4-piperidone(cas: 1445-73-4Category: piperidines)

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Synthetic Route of C6H11NOIn 2022 ,《Supported Anionic Gold Nanoparticle Catalysts Modified Using Highly Negatively Charged Multivacant Polyoxometalates》 was published in Angewandte Chemie, International Edition. The article was written by Xia, Kang; Yatabe, Takafumi; Yonesato, Kentaro; Yabe, Tomohiro; Kikkawa, Soichi; Yamazoe, Seiji; Nakata, Ayako; Yamaguchi, Kazuya; Suzuki, Kosuke. The article contains the following contents:

Although supported anionic gold nanoparticle catalysts have been theor. investigated for their efficacy in activating O2 in aerobic oxidation reactions, limited studies have been reported due to the difficulty of designing these catalysts. Herein, we developed a feasible method for preparing supported anionic gold nanoparticle catalysts using multivacant lacunary polyoxometalates with high neg. charges. We confirmed the strong and robust electronic interaction between gold nanoparticles and multivacant lacunary polyoxometalates, and the electronic states of the supported gold nanoparticle catalysts can be sequentially modulated. Particularly, the catalyst prepared using [SiW9O34]10- acted as an efficient reusable heterogeneous catalyst, showing superior catalytic performance for the oxidative dehydrogenation of piperidone derivatives to the corresponding enaminones and remarkably higher stability than supported gold nanoparticle catalysts without this modification. In the part of experimental materials, we found many familiar compounds, such as 1-Methyl-4-piperidone(cas: 1445-73-4Synthetic Route of C6H11NO)

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine-containing compounds are also frequently employed in synthesis as ligands or auxiliaries. Accordingly, many efforts have been devoted to the development of novel methods for the synthesis of these compounds over the years.Synthetic Route of C6H11NO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In 2022,Liu, Binghui; Duan, Yuting; Li, Tingting; Li, Jialin; Zhang, Haiqiu; Zhao, Chengji published an article in Separation and Purification Technology. The title of the article was 《Nanostructured anion exchange membranes based on poly(arylene piperidinium) with bis-cation strings for diffusion dialysis in acid recovery》.Category: piperidines The author mentioned the following in the article:

A series of anion exchange membranes (AEMs) based on poly(arylene piperidinium) with bis-cation strings were prepared by a simple synthetic method for diffusion dialysis (DD). Through Menshutkin reaction, 1-(6-bromohexyl)-1-methylpiperidinium bromide was grafted onto the hydrophobic poly(arylene piperidine) backbone to produce side-chain-type AEMs with bis-piperidinium strings (QPBPipXAc). The self-assembled nanostructure of these AEMs was verified by SAXS and AFM images. The properties and DD performance of QPBPipXAc AEMs with different contents of bis-piperidinium ionic groups were systematically studied, including mech. properties, ionic conductivity, thermal stability. The prepared AEMs demonstrated favorable overall properties due to the formation of self-assembled nanostructured hydrophilic-hydrophobic phase separation morphol. The hydrophilic domains provide more efficient ion transport channels for high acid flux, whereas the hydrophobic domains restrict the AEMs swelling and Fe2+ ion transport. The prepared QPBPipXAc AEMs displayed high H+ dialysis coefficients (UH+, 10 x 10-3 – 65 x 10-3 m/h) and separation coefficients (S, 15.67-25.38). Compared with the com. membrane DF-120 (UH+ = 9 x 10-3 m/h, S = 18.5), the prepared AEMs have better diffusion dialysis performance, indicating that they could be the potential candidates for application for acid recovery. In the experimental materials used by the author, we found 1-Methyl-4-piperidone(cas: 1445-73-4Category: piperidines)

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In 2022,Wu, Xingyu; Chen, Nanjun; Klok, Harm-Anton; Lee, Young Moo; Hu, Xile published an article in Angewandte Chemie, International Edition. The title of the article was 《Branched Poly(Aryl Piperidinium) Membranes for Anion-Exchange Membrane Fuel Cells》.HPLC of Formula: 1445-73-4 The author mentioned the following in the article:

Anion-exchange membrane fuel cells (AEMFCs) are a promising, next-generation fuel cell technol. AEMFCs require highly conductive and robust anion-exchange membranes (AEMs), which are challenging to develop due to the tradeoff between conductivity and water uptake. Here we report a method to prepare high-mol.-weight branched poly(aryl piperidinium) AEMs. We show that branching reduces water uptake, leading to improved dimensional stability. The optimized membrane, b-PTP-2.5, exhibits simultaneously high OH- conductivity (>145 mS cm-1 at 80 °C), high mech. strength and dimensional stability, good processability, and excellent alk. stability (>1500 h) in 1 M KOH at 80 °C. AEMFCs based on b-PTP-2.5 reached peak power densities of 2.3 W cm-2 in H2-O2 and 1.3 W cm-2 in H2-air at 80 °C. The AEMFCs can run stably under a constant current of 0.2 A cm-2 over 500 h, during which the b-PTP-2.5 membrane remains stable. In the experiment, the researchers used 1-Methyl-4-piperidone(cas: 1445-73-4HPLC of Formula: 1445-73-4)

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.HPLC of Formula: 1445-73-4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Tang, Weiqin; Mu, Tong; Che, Xuefu; Dong, Jianhao; Yang, Jingshuai published their research in ACS Sustainable Chemistry & Engineering in 2021. The article was titled 《Highly Selective Anion Exchange Membrane Based on Quaternized Poly(triphenyl piperidine) for the Vanadium Redox Flow Battery》.Recommanded Product: 1445-73-4 The article contains the following contents:

Vanadium redox flow batteries (VRFBs) have attracted great attention recently owing to the increasing supply of intermittent renewable energies. However, VRFBs usually suffer from serious vanadium ion crossover and high cost when perfluorinated membranes are employed as the separator. In this study, a highly selective anion exchange membrane (AEM) is synthesized from the aryl ether-free poly(terphenyl piperidine) (PTP). Using 3-chloro-2-hydroxypropyltrimethyl ammonium chloride (CHPTMA-Cl) as the quaternization reagent, not only are the piperidinium cations formed in the PTP main chain, but also the side-chain quaternary ammonium cation and hydroxyl group are introduced into the PTP backbone. Compared with pure PTP-TFA and Me quaternized PTP (PTP-Me) membranes, the obtained hydroxypropyltrimethyl ammonium grafted poly(terphenyl piperidinium) (PTP-CHPTMA) membrane exhibits high H+ permeability (1.82 x 10-5 cm2 min-1) and low area resistance (0.35 Ω cm2) mainly due to the presence of the hydrophilic hydroxyl group. Owing to the electrostatic repulsion effect of main-chain piperidinium and side-chain quaternary ammonium cations to vanadium ions, the PTP-CHPTMA membrane achieves a low vanadium ion permeability (1.21 x 10-8 cm2 min-1). Consequently, the PTP-CHPTMA membrane reaches 2 orders of magnitude higher ion selectivity than Nafion 115. The assembled single VRFB with PTP-CHPTMA possesses high Coulombic efficiencies of close to 100% at 60-160 mA cm-2 and higher energy efficiencies than the cell with Nafion 115. The self-discharge duration of the cell with PTP-CHPTMA (381 h) is nearly 4.5 times longer than that of Nafion 115 (86 h). Meanwhile, the VRFB based on PTP-CHPTMA displays excellent cycle stability and discharge capacity retention over 580 charge-discharge cycles at 100 mA cm-2. The results came from multiple reactions, including the reaction of 1-Methyl-4-piperidone(cas: 1445-73-4Recommanded Product: 1445-73-4)

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine is ubiquitous structural motif widely occurred in diverse synthetically and naturally occurring bioactive molecules. Piperidines are an immensely important class of compounds medicinally: the piperidine ring is the most common heterocyclic subunit among FDA approved drugs.Recommanded Product: 1445-73-4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Product Details of 1445-73-4In 2021 ,《High chemical stability anion exchange membrane based on poly(aryl piperidinium): Effect of monomer configuration on membrane properties》 appeared in International Journal of Hydrogen Energy. The author of the article were Long, Chuan; Wang, Zhihua; Zhu, Hong. The article conveys some information:

In recent years, ether-free polyaryl polymers prepared by superacid-catalyzed Friedel-Crafts polymerization have attracted great research interest in the development of anion exchange membranes(AEMs) due to their high alkali resistance and simple synthesis methods. However, the selection of monomers for high-performance polymer backbone and the relationship between polymer structure construction and properties need further investigated. Herein, a series of free-ether poly(aryl piperidinium) (PAP) with different polymer backbone steric construction were synthesized as stable anion exchange membranes. Meta-terphenyl, p-terphenyl and diphenyl-terphenyl copolymer were chosen as monomers to regulate the spatial arrangement of the polymer backbone, which tethered with stable piperidinium cation to improve the chem. stability. In addition, a multi-cation crosslinking strategy has been applied to improve ion conductivity and mech. stability of AEMs, and further compared with the performance of uncrosslinked AEMs. The properties of the resulting AEMs were investigated and correlated with their polymer structure. In particular, m-terphenyl based AEMs exhibited better dimensional stability and the highest hydroxide conductivity of 144.2 mS/cm at 80°C than other membranes, which can be attributed to their advantages of polymer backbone arrangement. Furthermore, the hydroxide conductivity of the prepared AEMs remains 80%-90% after treated by 2 M NaOH for 1600 h, exhibiting excellent alk. stability. The single cell test of m-PTP-20Q4 exhibits a maximum power d. of 239 mW/cm2 at 80°C. Hence, the results may guide the selection of polymer monomers to improve performance and alk. durability for anion exchange membranes.1-Methyl-4-piperidone(cas: 1445-73-4Product Details of 1445-73-4) was used in this study.

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine-containing compounds are also frequently employed in synthesis as ligands or auxiliaries. Accordingly, many efforts have been devoted to the development of novel methods for the synthesis of these compounds over the years.Product Details of 1445-73-4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Chen, Nanjun; Jin, Yiqi; Liu, Haijun; Hu, Chuan; Wu, Bo; Xu, Shaoyi; Li, Hui; Fan, Jiantao; Lee, Young Moo published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Insight into the Alkaline Stability of N-Heterocyclic Ammonium Groups for Anion-Exchange Polyelectrolytes》.Related Products of 1445-73-4 The article contains the following contents:

The alk. stability of N-heterocyclic ammonium (NHA) groups is a critical topic in anion-exchange membranes (AEMs) and AEM fuel cells (AEMFCs). Here, we report a systematic study on the alk. stability of 24 representative NHA groups at different hydration numbers (λ) at 80°C. The results elucidate that γ-substituted NHAs containing electron-donating groups display superior alk. stability, while electron-withdrawing substituents are detrimental to durable NHAs. D.-functional-theory calculations and exptl. results suggest that nucleophilic substitution is the dominant degradation pathway in NHAs, while Hofmann elimination is the primary degradation pathway for NHA-based AEMs. Different degradation pathways determine the alk. stability of NHAs or NHA-based AEMs. AEMFC durability (from 1 A cm-2 to 3 A cm-2) suggests that NHA-based AEMs are mainly subjected to Hofmann elimination under 1 A cm-2 c.d. for 1000 h, providing insights into the relationship between c.d., λ value, and durability of NHA-based AEMs. In the part of experimental materials, we found many familiar compounds, such as 1-Methyl-4-piperidone(cas: 1445-73-4Related Products of 1445-73-4)

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine-containing compounds are also frequently employed in synthesis as ligands or auxiliaries. Accordingly, many efforts have been devoted to the development of novel methods for the synthesis of these compounds over the years.Related Products of 1445-73-4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

In 2019,European Journal of Medicinal Chemistry included an article by Yao, Bin-Rong; Sun, Yue; Chen, Shuang-Long; Suo, Hao-Dong; Zhang, Yu-Long; Wei, Hao; Wang, Chun-Hua; Zhao, Feng; Cong, Wei; Xin, Wen-Yu; Hou, Gui-Ge. Related Products of 1445-73-4. The article was titled 《Dissymmetric pyridyl-substituted 3,5-bis(arylidene)-4-piperidones as anti-hepatoma agents by inhibiting NF-κB pathway activation》. The information in the text is summarized as follows:

A series of dissym. pyridyl-substituted 3,5-bis(arylidene)-4-piperidones (BAPs, I [R1 = 3-pyridinyl, 4-pyridinyl; R2 = 2-F, 4-cyano, 3,4,5-OMe, etc.] II[R3 = 3-pyridinyl, 4-pyridinyl; R4 = F, CF3; R5 = H, Cl, CF3, etc]) were designed and synthesized to get new anti-hepatoma agents with anti-inflammatory activity and hypotoxicity. Many of them exhibited potential anti-hepatoma properties against human hepatocellular carcinoma cell lines (HepG2, QGY-7703, SMMC-7721) and hypotoxicity for human normal heptical cell line (HHL-5, LO2) and prominently inhibited lipopolysaccharides (LPS) induced IL-6, TNF-α secretion to exert its anti-inflammatory effect. Combining the data of cytotoxicity, cytocompatibility and anti-inflammatory activity, II [R3 = 3-pyridinyl; R4 = R5 = CF3] may be the potential anti-hepatoma agent. II [R3 = 3-pyridinyl; R4 = R5 = CF3] effectively promoted cell apoptosis through up-regulating cleaved caspase-3 and Bax expression and down-regulating Bcl-2 expression. Furthermore, II [R3 = 3-pyridinyl; R4 = R5 = CF3]prominently inhibited NF-κB pathway activation by blocking the phosphorylation of IκBα, p65 and the nuclear translocation of NF-κB induced by TNF-α and LPS. In addition, II [R3 = 3-pyridinyl; R4 = R5 = CF3] could reasonably bind to the active site of Bcl-2 and NF-κB/p65 protein proved by Mol. docking analyses. Moreover, II [R3 = 3-pyridinyl; R4 = R5 = CF3] significantly suppressed the growth and inflammatory response of HepG2 xenografts in nude mice and was relatively nontoxic to mice. These results suggested that II [R3 = 3-pyridinyl; R4 = R5 = CF3] may be effective and hypotoxicity anti-hepatoma agent for the clin. treatment of liver cancers. In the part of experimental materials, we found many familiar compounds, such as 1-Methyl-4-piperidone(cas: 1445-73-4Related Products of 1445-73-4)

1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.Related Products of 1445-73-4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem