Category: 142752-12-3

Electric Literature of 142752-12-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.142752-12-3, Name is 1-(4-Aminophenyl)piperidin-4-ol, molecular formula is C11H16N2O. In a Patent，once mentioned of 142752-12-3

The present invention relates to novel pyrimide derivatives of formula (I): that are useful as kinase inhibitors. More particularly, the present invention relates to novel pyrimidine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative disorders

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Electric Literature of 142752-12-3, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 142752-12-3

Reference：
Piperidine – Wikipedia,
Piperidine | C5H12849N – PubChem

 

Application of 142752-12-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.142752-12-3, Name is 1-(4-Aminophenyl)piperidin-4-ol, molecular formula is C11H16N2O. In a Patent，once mentioned of 142752-12-3

Compounds, particularly compounds having spleen tyrosine kinase (Syk) inhibition activity, having the following structure: or a pharmaceutically acceptable salt thereof, wherein R1 is structure (a), (b), (c) or (d): and Ra, Rb, Rc, R2, R3, R4, R5, R6 and R7 are as defined herein. Methods associated with preparation and use of the same, as well as pharmaceutical compositions containing the same, are also disclosed, as well as uses of the same to treat a condition or disorder mediated by a Syk and/or JAK kinase

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 142752-12-3 is helpful to your research. Application of 142752-12-3

Reference：
Piperidine – Wikipedia,
Piperidine | C5H12859N – PubChem

 

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Formula: C11H16N2O, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 142752-12-3, Name is 1-(4-Aminophenyl)piperidin-4-ol, molecular formula is C11H16N2O. In a Patent, authors is ，once mentioned of 142752-12-3

The present invention is directed to compounds of formula (I)-(II) and pharmaceutically acceptable salts, esters, and prodrugs thereof which are inhibitors of syk and/or JAK kinase. The present invention is also directed to intermediates used in making such compounds, the preparation of such a compound, pharmaceutical compositions containing such a compound, methods of inhibition syk and/or JAK kinase activity, methods of inhibition the platelet aggregation, and methods to prevent or treat a number of conditions mediated at least in part by syk and/or JAK kinase activity, such as undesired thrombosis and Non Hodgkin’s Lymphoma.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 142752-12-3, help many people in the next few years.Formula: C11H16N2O

Reference：
Piperidine – Wikipedia,
Piperidine | C5H12851N – PubChem

 

Electric Literature of 142752-12-3, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 142752-12-3, Name is 1-(4-Aminophenyl)piperidin-4-ol, molecular formula is C11H16N2O. In a Article£¬once mentioned of 142752-12-3

Novel compounds reducing IRS-1 serine phosphorylation for treatment of diabetes

Activation of various interacting stress kinases, particularly the c-Jun N-terminal kinases (JNK), and a concomitant phosphorylation of insulin receptor substrate 1 (IRS-1) at serine 307 play a central role both in insulin resistance and in beta-cell dysfunction. IRS-1 phosphorylation is stimulated by elevated free fatty acid levels through different pathways in obesity. A series of novel pyrido[2,3-d]pyrimidin-7-one derivatives were synthesized as potential antidiabetic agents, preventing IRS-1 phosphorylation at serine 307 in a cellular model of lipotoxicity and type 2 diabetes.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Electric Literature of 142752-12-3, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 142752-12-3, in my other articles.

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H12860N – PubChem

 

142752-12-3, 1-(4-Aminophenyl)piperidin-4-ol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 141-{4-fluoro-2-[4-(4-hydroxypiperidin-1-yl)phenylamino]benzyl}-3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethylimidazolidine-2,4-dione; hydrochloride; 0.16 g of compound 3.2 was admixed with 0.10 g of 1-(4-aminophenyl)-piperidin-4-ol, 8 mg of palladium(II) acetate, 39 mg of 9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene and 0.33 g of cesium carbonate, before 10 ml of dry dioxane were added under an argon atmosphere. The mixture was stirred at 80 C. for 6 h. The cooled reaction mixture was filtered with suction, the filtrate was concentrated under reduced pressure and the residue was purified by chromatography (method [RP1]). The eluates were concentrated, admixed with hydrochloric acid in dioxane and freeze-dried. This afforded 1-{4-fluoro-2-[4-(4-hydroxypiperidin-1-yl)phenylamino]benzyl}-3-(4-fluoro-3-trifluoromethylphenyl)-5,5-dimethyl imidazolidine-2,4-dione as the hydrochloride (14). Molecular weight (free base) 588.21 (C30H29F5N4O3); retention time Rt=3.91 min. [D]; MS (ESI): 589.52 (MH+)., 142752-12-3

The synthetic route of 142752-12-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SANOFI-AVENTIS; US2011/46105; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.142752-12-3,1-(4-Aminophenyl)piperidin-4-ol,as a common compound, the synthetic route is as follows.

A mixture of starting material (12 mg, 0.05 mmol), 1-(4-aminophenyl)piperidin-4-ol (10 mg, 0.05 mmol), X-Phos (4.3 mg), Pd2(dba)3 (5.5 mg) and K2CO3 (30 mg, 0.22 mmol) in t-BuOH (1.0 mL) was heated at 85 C. in a seal tube for 4 h. The reaction was then filtered through celite, eluted with dichloromethane, and concentrated in vacuo. The residue was then purified by reverse-phase prep-HPLC to afford the title compound as the TFA salt (8.2 mg, 40%).

142752-12-3, As the paragraph descriping shows that 142752-12-3 is playing an increasingly important role.

Reference£º
Patent; DANA-FARBER CANCER INSTITUTE, INC.; Gray, Nathanael S.; Waller, David; Choi, Hwan Guen; Wang, Jinhua; Deng, Xianming; (104 pag.)US2016/24115; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem