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The invention relates to novel compounds which are both phosphodiesterase 4 (PDE4) enzymeinhibitorsand muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof.

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Piperidine – Wikipedia,
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The invention relates to novel antibacterial compounds of formula (I). Said compounds are of interest, inter alia, as topoisomerase IV (topo IV) and DNA gyrase inhibitors.

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Disclosed are the ERK inhibitors of formula (1): and the pharmaceutically acceptable salts thereof, wherein: A is a five membered monocyclic heteroaryl ring and B is a monocyclic heterocycloalkyl ring, or a monocyclic heterocyclo alkenyl ring, or a bridged monocyclic heterocyclo alkyl ring, or a fused (monocyclic heterocyclo alkyl ring)cyclopropyl ring. Also disclosed are methods of treating cancer using the compounds of formula (1)

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Chemical optimization of pyrazolopyridine 1, focused on cellular potency, isoform selectivity and microsomal stability, led to the discovery of the potent, selective and orally available PI3Kdelta inhibitor 5d. On the basis of its desirable potency, selectivity and pharmacokinetic profiles, 5d was tested in the trinitrophenylated aminoethylcarboxymethyl-Ficoll (TNP-Ficoll)-induced antibody production model, and showed higher antibody inhibition than a 4-fold oral dose of the starting compound 1. These excellent results suggest that 5d is a potential candidate for further studies in the treatment of autoimmune diseases and leukocyte malignancies.

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IMIDAZOPYRAZINES AS LSD1 INHIBITORS

The present invention is directed to imidazo[1,2-a]pyrazine derivatives which are LSD1 inhibitors useful in the treatment of diseases such as cancer.

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2-CARBAMIDE-4-PHENYLTHIAZOLE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF

The disclosure relates to 2-carbamide-4-phenylthiazole derivatives having the following general formula (I):wherein R1, R2, R3, Y and p are as defined in the disclosure. The disclosure also relates to pharmaceutical compositions containing a compound of formula (I), to processes for preparing the compounds of formula (I), and to methods of using the compounds of formula (I).

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A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Application In Synthesis of (R)-tert-Butyl 3-(hydroxymethyl)piperidine-1-carboxylate, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 140695-85-8, Name is (R)-tert-Butyl 3-(hydroxymethyl)piperidine-1-carboxylate, molecular formula is C11H21NO3. In a Patent, authors is £¬once mentioned of 140695-85-8

NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS

Disclosed herein are compounds of formula (I) wherein R1, R2, R3, R25a, R26a, X, and n are as defined in the specification. Pharmaceutical compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and pharmaceutical compositions are also described

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2-CARBAMIDE-4-PHENYLTHIAZOLE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF

The disclosure relates to 2-carbamide-4-phenylthiazole derivatives having the following general formula (I):wherein R1, R2, R3, Y and p are as defined in the disclosure. The disclosure also relates to pharmaceutical compositions containing a compound of formula (I), to processes for preparing the compounds of formula (I), and to methods of using the compounds of formula (I).

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NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS

Disclosed herein are compounds of formula (I) wherein R1, R2, R3, R25a, R26a, X, and n are as defined in the specification. Pharmaceutical compositions comprising such compounds, and methods of treating conditions and disorders using such compounds and pharmaceutical compositions are also described

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Enzymatic Preparation of Chiral 3-(Hydroxymethyl)piperidine Derivatives

t-Butyl (R)-3-(hydroxymethyl)-1-piperidinecarboxylate was prepared with lipase P in up to 98 percent ee by means of enantioselective esterification of the racemic alcohol as well as by enantioselective hydrolysis of the corresponding butyryl ester and subsequent chemical hydrolysis of the retained (R)-ester.A work-up procedure feasible on the kg-scale is described.

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