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Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 140645-23-4, molcular formula is C11H22N2O2, introducing its new discovery. Recommanded Product: 140645-23-4

The color additive, Allura Red AC, was given in the diet to provide levels of 0.42, 0.84, and 1.68% (control, 0%), from 5 weeks of age of the F0 generation to 9 weeks of age of the F1 generation in mice, and selected reproductive and neurobehavioral parameters were measured. There were few adverse effects of Allura Red AC on either litter size or weight, and ratio of male to female was significantly reduced in the lowest dosed group. Average body weight of offspring during the lactation period was significantly increased in the lower dosed groups of each sex. As regards the neurobehavioral parameters, no adverse effect was observed in the behavioral development during lactation period. There were few adverse effects of Allura Red AC on either movement activity or maze learning in F1 generation mice, compared with controls in each sex. The dose levels of Allura Red AC in the present study (approximately 86-1430 times greater than human ADI) produced few adverse effects in reproductive and neurobehavioral parameters in mice.

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Binding interaction of human serum albumin (HSA) with allura red AC, a food colourant, was investigated at the molecular level through fluorescence, ultraviolet-visible, circular dichroism (CD) and Raman spectroscopies, as well as protein-ligand docking studies to better understand the chemical absorption, distribution and transportation of colourants. Results show that allura red AC has the ability to quench the intrinsic fluorescence of HSA through static quenching. The negative values of the thermodynamic parameters DeltaG, DeltaH, and DeltaS indicated that hydrogen bond and van der Waals forces are dominant in the binding between the food colourant and HSA. The CD and Raman spectra showed that the binding of allura red AC to HSA induces the rearrangement of the carbonyl hydrogen-bonding network of polypeptides, which changes the HSA secondary structure. This colourant is bound to HSA in site I, and the binding mode was further analysed with the use of the CDOCKER algorithm in Discovery Studio.

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In the present work, nanocrystalline disodium 6-hydroxy-5-[(2-methoxy-5-methyl-4-sulfophenyl) azo]-2-naphthalenesulfonate (AR) thin films based devices were prepared by using electro-spin technique under best conditions. The nanostructure characteristics of the AR surfaces were found to be nanosphere-like structure by using scanning electron microscopy (SEM). The dark and 100 mW/cm2 illuminated current density?voltage (J?V) characteristics of the prepared heterojunctions by using different metal like Pt, Al and Cu were discussed at a temperature of 300 K. A diode-like behavior was obtained for all the studied devices and the rectification characteristics were obtained and compared. In addition, the arrangement protection and ideality factors demonstrated high interface reliance. Exposure of light on the AR dye / different metal structures produces a photocurrent which suggests the production of free carriers in all cases with different values which elucidate that these structures are promising for optoelectronic device applications.

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A novel method for detecting allura red based on triple-wavelength overlapping resonance Rayleigh scattering

A method is presented for the sensitive and selective determination of trace allura red (AR) with ethyl violet (EV) in drink samples, based on triple-wavelength overlapping resonance Rayleigh scattering (TWO-RRS). At pH 10.0 in a Britton-Robinson (BR) buffer medium, AR combined with EV to form an ion-association complex, which resulted in the RRS intensity getting enhanced significantly with new RRS peaks appearing at 341, 508 and 666 nm. The scattering intensities of the three peaks were proportional to the concentration of AR in the range of 0.057-5.0 mumol L-1 (0.028-2.48 mug mL-1). The detection limits for the three single peaks were 0.048 mumol L-1 (0.024 mug mL-1), 0.050 mumol L -1 (0.025 mug mL-1), and 0.057 mumol L-1 (0.028 mug mL-1), while that of the TWO-RRS method was 0.017 mumol L-1 (0.008 mug mL-1), indicating that the TWO-RRS method could detect trace AR with high sensitivity. In addition, the optimum reaction conditions and the effects of foreign substances were studied. The composition of the ion-association complex, and the reasons for the enhancement of RRS were also investigated. The proposed method was successfully applied in a real sample analysis with satisfactory results. the Partner Organisations 2014.

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(R)-tert-butyl 3-(((3-amino-6-bromopyrazine-2-yl)amino)methyl)piperidine- 1 -carboxylate._10239] (R)-tert-butyl 3-(aminomethyl)piperidine-1 -carboxylate (4.97 g, 22.40 mmol) was dissolved in DMSO (80 ml), and then 3,5-dibromopyrazine-2-amine (8.5 g, 33.60 mmol) and Et3N (6.3 ml) were added, followed by stirring at 130 C. overnight. Afier the completion of the reaction, the reaction mixture was extracted with H20, EA, and brine, followed by drying (Na2SO4), filtration, and concentration under reduced pressure, and the residue was purified by column chromatography (EA:Hex=1:1), to give (R)-tert-butyl 3-(((3-amino-6-bromopyrazine-2-yl)amino)methyl)piperi- dine-i-carboxylate (2.19 g, two steps: 26%).10240] ?H-NMR (300 MHz, CDC13) oe 7.39 (s, 1H), 4.64-4.23 (m, 2H), 3.79-2.92 (m, 5H), 2.25-1.19 (m, 4H), 1.46 (s, 9H)

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Reference£º
Patent; KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; HANDOK INC.; Jung, Hee Jung; Ha, Jae Du; Cho, Sung Yun; Kim, Hyoung Rae; Lee, Kwang Ho; Lee, Chong Ock; Choi, Sang Un; Park, Chi Hoon; US2015/259350; (2015); A1;,
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