Category: 139290-70-3

Chemistry is an experimental science, Formula: C13H24N2O4, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 139290-70-3, Name is tert-Butyl 4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate

AMINE DERIVATIVES AS POTASSIUM CHANNEL BLOCKERS

The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv 1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Formula: C13H24N2O4, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 139290-70-3, in my other articles.

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H22005N – PubChem

 

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 139290-70-3, name is tert-Butyl 4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate, introducing its new discovery. Recommanded Product: tert-Butyl 4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate

N,N-diethyl-4-(phenylpiperidin-4-ylidenemethyl)benzamide: A novel, exceptionally selective, potent delta opioid receptor agonist with oral bioavailability and its analogues

The design, synthesis, and pharmacological evaluation of a novel class of delta opioid receptor agonists, N,N-diethyl-4-(phenylpiperidin-4-ylidenemethyl)benzamide (6a) and its analogues, are described. These compounds, formally derived from SNC-80 (2) by replacing the piperazine ring with a piperidine ring containing an exocyclic carbon carbon double bond, were found to bind with high affinity and exhibit excellent selectivity for the delta opioid receptor as full agonists. 6a, the simplest structure in the class, exhibited an IC50 = 0.87 nM for the delta opioid receptors and extremely high selectivity over the mu receptors (mu/delta = 4370) and the kappa receptors (kappa/delta = 8590). Rat liver microsome studies on a selected number of compounds show these olefinic piperidine compounds (6) to be considerably more stable than SNC-80. This novel series of compounds appear to interact with delta opioid receptors in a similar way to SNC-80 since they demonstrate similar SAR. Two general approaches have been established for the synthesis of these compounds, based on dehydration of benzhydryl alcohols (7) and Suzuki coupling reactions of vinyl bromide (8), and are herewith reported.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 139290-70-3 is helpful to your research. Recommanded Product: tert-Butyl 4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H22063N – PubChem