Category: 13925-07-0

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 13925-07-0, Name is 2-Ethyl-3,5-dimethylpyrazine, molecular formula is C8H12N2. In an article, author is Arico, Fabio,once mentioned of 13925-07-0, Computed Properties of C8H12N2.

beta-Aminocarbonates in Regioselective and Ring Expansion Reactions

The reactivity of beta-aminocarbonates as anisotropic electrophiles has been investigated with several phenols. Products distribution shows that the regioselectivity of the anchimerically driven alkylation reaction depends on the nucleophiles. The results suggest that in the presence of nucleophiles that are also good leaving groups, the reaction takes place under thermodynamic control favoring the attack on the most sterically hindered carbon of the cyclic aziridinium intermediate. Furthermore, when an enantiomerically pure pyrrolidine-based carbonate was used, the reaction with phenols proceeds via a bicyclic aziridinium intermediate leading to the stereoselective synthesis of optically active 3-substituted piperidines via ring expansion reaction. These results were confirmed both by NMR spectroscopy and X-ray diffraction analysis.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 13925-07-0, Name is 2-Ethyl-3,5-dimethylpyrazine. In a document, author is Yang, Shaoning, introducing its new discovery. Quality Control of 2-Ethyl-3,5-dimethylpyrazine.

Design, synthesis and evaluation of substituted piperidine based KCNQ. openers as novel antiepileptic agents

Epilepsy is a land of disease with complicated pathogenesis. KCNQ (Kv7) is a voltage dependent potassium channel that is mostly associated with epilepsy and thus becomes an important target in the treatment of epilepsy. In this paper, a series of substituted piperidine derivatives targeting KCNQ were designed and synthesized by using scaffold hopping and active substructure hybridization. Compounds were evaluated by fluorescence-based thallium influx assay, Rb+ flow assay and electrophysiological patch-clamp assay. Results showed that some compounds possessed more potent potassium channel opening activity than Retigabine. More significantly, compound 11 was found to have good pharmacokinetic profiles in vivo. (C) 2018 Elsevier Ltd. All rights reserved.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 13925-07-0, Name is 2-Ethyl-3,5-dimethylpyrazine, molecular formula is , belongs to piperidines compound. In a document, author is Dawood, Rafid S., Recommanded Product: 13925-07-0.

Synthesis, identification and molecular docking studies ofN-functionalized piperidine derivatives linked to 1,2,3-triazole ring

New derivatives of piperidine bearing a 1,2,3-triazole ring designed and synthesized smoothly over six steps fromN-protected piperidone-4-one. These steps included reduction of the carbonyl group/tosylation of the resulting alcohol providing tosyl derivative in a good yield, followed by nucleophilic substitution and Cu-catalysed azide-alkyne cycloaddition. By removing the protecting group and functionalizing amine groupviareductive amination gave the desired design in moderate to very good yields. Molecular modeling studies of these compounds predicted possible binding modes into the active site of dopamine receptor D2.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 13925-07-0, in my other articles. Recommanded Product: 13925-07-0.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Lakkakula, Ravi, once mentioned the application of 13925-07-0, Name is 2-Ethyl-3,5-dimethylpyrazine, molecular formula is C8H12N2, molecular weight is 136.1943, MDL number is MFCD00047392, category is piperidines. Now introduce a scientific discovery about this category, SDS of cas: 13925-07-0.

An Efficient and Straightforward Total Synthesis of (+/-)-Preclamol

A prudent and scalable synthesis of (+/-)-Preclamol is described utilizing Michael addition and in-situ reduction/cyclization of an aryl-alpha-carbethoxy acetonitrile derivative as a key step.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 13925-07-0, Name is 2-Ethyl-3,5-dimethylpyrazine, SMILES is CCC1=C(C)N=C(C)C=N1, in an article , author is Wang, Haixing, once mentioned of 13925-07-0, Product Details of 13925-07-0.

Chemical Profiling of Lobelia chinensis with High-Performance Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry (HPLC/Q-TOF MS) Reveals Absence of Lobeline in the Herb

Lobelia chinensis is a kind of herbal medicine widely distributed and used in Asia. The chemical components of this herb, however, have not been well studied until now. Lobeline, as an essential and famous bioactive compound in Lobelia genus, has been assumed to be present in L. chinensis. In order to ascertain its presence and, more importantly, proper use of this herb, chemical profiling this herb with highly sensitive and high-resolution analytical mass spectrometry was applied. In this study, high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (HPLC/Q-TOF MS) method was employed to systematically profile the chemical constituents of L. chinensis for the first time. Comparative chemical profiling study of L. chinensis and Lobelia inflata was also conducted to provide evidence whether lobeline is present or not. Piperidine alkaloids except for lobeline, alkaloid-lignan hybrids, flavonoids, polyacetylenes, nonanedioic acid, and some new phytochemicals were successfully identified in L. chinensis simultaneously. Comparing to the chemical profiles of L. inflata, lobeline was found to be absent in L. chinensis. All of the secondary metabolites in L. chinensis were determined with the HPLC/Q-TOF MS method. The absence of lobeline in L. chinensis was confirmed after this extensive study.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Product Details of 13925-07-0, 13925-07-0, Name is 2-Ethyl-3,5-dimethylpyrazine, SMILES is CCC1=C(C)N=C(C)C=N1, in an article , author is Moi, Davide, once mentioned of 13925-07-0.

Appliance of the piperidinyl-hydrazidoureido linker to benzenesulfonamide compounds: Synthesis, in vitro and in silico evaluation of potent carbonic anhydrase II, IX and XII inhibitors

Herein we report on a new series of hydrazidoureidobenzensulfonamides investigated as inhibitors of the cytosolic human (h) hCA I and II isoforms, as well as the transmembrane, tumor-associated enzymes hCA IX and XII. The reported derivatives contain a 4-substituted piperidine fragment in which the hydrazidoureido linker has been involved as spacer between the benzenesulfonamide fragment which binds the zinc ion from the active site, and the tail of the inhibitor. Depending on the substitution pattern at the piperidine ring, low nanomolar inhibitors were detected against hCA II, hCA IX and hCA XII, making the new class of sulfonamides of interest for various pharmacologic applications.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Synthetic Route of 13925-07-0, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 13925-07-0, Name is 2-Ethyl-3,5-dimethylpyrazine, SMILES is CCC1=C(C)N=C(C)C=N1, belongs to piperidines compound. In a article, author is Tong, Wen, introduce new discover of the category.

Modified Ti-MWW Zeolite as a Highly Efficient Catalyst for the Cyclopentene Epoxidation Reaction

The liquid-phase epoxidation of cyclopentene (CPE) was performed in the Ti-zeolite/H(2)O(2)catalytic system for the clean synthesis of cyclopentene oxide. Among all the Ti-zeolites (Ti-Beta, Ti-MOR, Ti-MCM-68, TS-1, TS-2, and Ti-MWW) investigated in the present study, Ti-MWW provided relatively lower CPE conversion of 13% due to the diffusion constrains but a higher CPO selectivity of 99.5%. The catalytic performance of Ti-MWW was significantly enhanced by piperidine (PI) treatment, with the CPE conversion and CPO selectivity increased to 97.8 and 99.9%, respectively. The structural rearrangement upon PI treatment converted the 3-dimensional (3D) MWW structure to a 2D lamellar one, which enlarged the interlayer space and greatly alleviated the diffusion constrains of cyclic cyclopentene. Furthermore, the newly constructed open site six-coordinated Ti active sites with PI as the ligand exhibited higher catalytic activity. The two factors contributed to more significant enhancement of the activity upon PI-assisted structural arrangement compared to the cases in linear alkenes.

Synthetic Route of 13925-07-0, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 13925-07-0.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Synthetic Route of 13925-07-0, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 13925-07-0, Name is 2-Ethyl-3,5-dimethylpyrazine, SMILES is CCC1=C(C)N=C(C)C=N1, belongs to piperidines compound. In a article, author is Munir, Rubina, introduce new discover of the category.

Microwave-Assisted Synthesis of (Piperidin-1-yl)quinolin-3-yl)methylene)hydrazinecarbothioamides as Potent Inhibitors of Cholinesterases: A Biochemical and In Silico Approach

Alzheimer’s disease (AD), a progressive neurodegenerative disorder, characterized by central cognitive dysfunction, memory loss, and intellectual decline poses a major public health problem affecting millions of people around the globe. Despite several clinically approved drugs and development of anti-Alzheimer’s heterocyclic structural leads, the treatment of AD requires safer hybrid therapeutics with characteristic structural and biochemical properties. In this endeavor, we herein report a microwave-assisted synthesis of a library of quinoline thiosemicarbazones endowed with a piperidine moiety, achieved via the condensation of 6/8-methyl-2-(piperidin-1-yl)quinoline-3-carbaldehydes and (un)substituted thiosemicarbazides. The target N-heterocyclic products were isolated in excellent yields. The structures of all the synthesized compounds were fully established using readily available spectroscopic techniques (FTIR, H-1- and C-13-NMR). Anti-Alzheimer potential of the synthesized heterocyclic compounds was evaluated using acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. The in vitro biochemical assay results revealed several compounds as potent inhibitors of both enzymes. Among them, five compounds exhibited IC50 values less than 20 mu M. N-(3-chlorophenyl)-2-((8-methyl-2-(piperidin-1-yl)quinolin-3-yl)methylene)hydrazine carbothioamide emerged as the most potent dual inhibitor of AChE and BChE with IC50 values of 9.68 and 11.59 mu M, respectively. Various informative structure-activity relationship (SAR) analyses were also concluded indicating the critical role of substitution pattern on the inhibitory efficacy of the tested derivatives. In vitro results were further validated through molecular docking analysis where interactive behavior of the potent inhibitors within the active pocket of enzymes was established. Quinoline thiosemicarbazones were also tested for their cytotoxicity using MTT assay against HepG2 cells. Among the 26 novel compounds, there were five cytotoxical and 18 showed proliferative properties.

Synthetic Route of 13925-07-0, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 13925-07-0 is helpful to your research.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , COA of Formula: C8H12N2, 13925-07-0, Name is 2-Ethyl-3,5-dimethylpyrazine, molecular formula is C8H12N2, belongs to piperidines compound. In a document, author is Isbera, Mostafa, introduce the new discover.

Syntheses and Reactions of Pyrroline, Piperidine Nitroxide Phosphonates

Organophosphorus compounds occupy a significant position among the plethora of organic compounds, but a limited number of paramagnetic phosphorus compounds have been reported, including paramagnetic phosphonates. This paper describes the syntheses and further transformations of pyrroline and piperidine nitroxide phosphonates by well-established methods, such as the Pudovik, Arbuzov and Horner-Wadsworth-Emmons (HWE) reactions. The reaction of paramagnetic alpha -bromoketone produced a vinylphosphonate in the Perkow reaction. Paramagnetic alpha -hydroxyphosphonates could be subjected to oxidation, elimination and substitution reactions to produce various paramagnetic phosphonates. The synthesized paramagnetic phosphonates proved to be useful synthetic building blocks for carbon-carbon bond-forming reactions in the Horner-Wadsworth-Emmons olefination reactions. The unsaturated compounds achieved could be transformed into various substituted pyrroline nitroxides, proxyl nitroxides and paramagnetic polyaromatics. The Trolox((R)) equivalent antioxidant capacity (TEAC) of new phosphonates was also screened, and tertiary alpha -hydroxyphosphonatate nitroxides exhibited remarkable antioxidant activity.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 13925-07-0. COA of Formula: C8H12N2.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem