Category: 138227-63-1

Related Products of 138227-63-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.138227-63-1, Name is tert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylate, molecular formula is C16H24N2O3. In a Patent，once mentioned of 138227-63-1

A compound useful for central antioxidant having inhibitory activity of degeneration and necrocytosis of cerebral cells of the formula (I): STR1 wherein A and B are independently (1) a group of the formula: STR2 wherein R1 and R2 are independently hydrogen atom, an optionally substituted hydrocarbon residue or an optionally substituted heterocyclic group, or R1 together with R2 and the nitrogen atom to which they are bound may form a cyclic amino group, provided that both R1 and R2 are not hydrogen atom at the same time, or (2) a group of the formula: STR3 wherein D is O or S, R3 is hydrogen atom, an optionally substituted hydrocarbon residue or an optionally substituted acyl group, m is 1, 2, or 3 and n is 0, 1, 2, 3 or 4; p is 1 or 2, provided that both A may be the same or different when p is 2; and R4, R5 and R6 are independently hydrogen atom, a lower alkyl or a lower alkoxy, or R5 and R6 may bond together to form –CH=CH–CH=CH–, or a salt thereof.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Related Products of 138227-63-1, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 138227-63-1

Reference：
Piperidine – Wikipedia,
Piperidine | C5H22948N – PubChem

 

Reference of 138227-63-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.138227-63-1, Name is tert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylate, molecular formula is C16H24N2O3. In a Patent，once mentioned of 138227-63-1

This invention is directed to benzenamine derivatives of formula (I): wherein A, W, m, n, R 1, R 2, R 3, R 4, R 5 and R 6 are defined herein. These compounds are useful as anti-coagulants.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 138227-63-1 is helpful to your research. Reference of 138227-63-1

Reference：
Piperidine – Wikipedia,
Piperidine | C5H22919N – PubChem

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， Computed Properties of C16H24N2O3, Which mentioned a new discovery about 138227-63-1

Mutant activin receptor-like kinase-2 (ALK2) was reported to be closely associated with the pathogenesis of fibrodysplasia ossificans progressiva (FOP) and diffuse intrinsic pontine glioma (DIPG), and therefore presents an attractive target for therapeutic intervention. Through in silico virtual screenings and structure?activity relationship studies assisted by X-ray crystallographic analyses, a novel series of bis-heteroaryl pyrazole was identified as potent inhibitors of ALK2 (R206H). Derived from in silico hit compound RK-59638 (6a), compound 18p was identified as a potent inhibitor of ALK2 (R206H) with good aqueous solubility, liver microsomal stability, and oral bioavailability.

Because enzymes can increase reaction rates by enormous factors and tend to be very specific, Computed Properties of C16H24N2O3, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 138227-63-1

Reference：
Piperidine – Wikipedia,
Piperidine | C5H22931N – PubChem

 

Application of 138227-63-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.138227-63-1, Name is tert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylate, molecular formula is C16H24N2O3. In a Article，once mentioned of 138227-63-1

A series of benzimidazole derivatives with the side chain on the nitrogen atom oriented to the prime site of factor Xa (FXa) were designed and synthesized. Compounds with substituted aminocarbonylmethyl groups as the side chain showed potent FXa inhibitory activity. Compounds 1 and 2 exhibited most potent inhibitory activity and were effective as anticoagulants in a DIC model.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 138227-63-1 is helpful to your research. Application of 138227-63-1

Reference：
Piperidine – Wikipedia,
Piperidine | C5H22946N – PubChem

 

Electric Literature of 138227-63-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.138227-63-1, Name is tert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylate, molecular formula is C16H24N2O3. In a Patent，once mentioned of 138227-63-1

Disclosed are compounds, compositions and methods for treating of disorders that are affected by the antagonism of one or more androgen receptor types. Such compounds are represented by Formula (I), wherein R1, R2a, R,2b, Z, X and Y are defined herein and G is selected (g1) or (g2).

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Electric Literature of 138227-63-1, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 138227-63-1

Reference：
Piperidine – Wikipedia,
Piperidine | C5H22934N – PubChem

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬ name: tert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylate, Which mentioned a new discovery about 138227-63-1

SUBSTITUTED ANILINE DERIVATIVES USEFUL AS HISTAMINE H3 ANTAGONISTS

Disclosed are compounds of the formula or a pharmaceutically acceptable salt thereof, wherein M1 is M2 is N; X is a bond, optionally substituted alkylene, alkenylene,–O–,–CH2N(R12)–,–N(R12)CH2–,–N(R12)–,–NHC(O)–,–OCH2–,–CH2O–, or–S(O)0-2–; and Y is–(CH2)1-2–,–C(=O)–,–C(=NOR13)–or–SO0-2–; or M1 is N; M2 is N or CH; X is a bond, alkylene, alkenylene,–C(O)–,–NHC(O)–,–OC(O)–or–S(O)1-2–; Y is–(CH2)1-2–,–C(=O)–or–SO0-2–; and when M2 is CH, Y is also Y is–O–or–C(=NOR13)–; Z is a bond or optionally substituted alkylene or alkenylene; U and W are CH, or one is CH and one is N; R1 is optionally substituted alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heterocycloalkyl; R2 is optionally substituted alkyl, alkenyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkyl or heterocycloalkyl; and the remaining variables are as defined in the specification; and compositions and methods of treating obesity, metabolic syndrome and a cognition deficit disorder, alone or in combination with other agents.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 138227-63-1, help many people in the next few years.name: tert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylate

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H22937N – PubChem

 

Related Products of 138227-63-1, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.138227-63-1, Name is tert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylate, molecular formula is C16H24N2O3. In a Patent£¬once mentioned of 138227-63-1

1,3,4-OXADIAZOLE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention relates to novel compounds having histone deacetylase 6 (HDAC6) in-hibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof, the use thereof for the preparation of therapeutic medicaments, pharmaceutical compositions containing the same, a method for treating diseases using the composition, and methods for preparing the novel compounds. The novel compounds, stereoisomers thereof or pharmaceutically acceptable salts thereof according to the present invention have histone deacetylase (HDAC) inhibitory activity and are effective for the prevention or treatment of HDAC6-mediated diseases, including infectious diseases; neoplasms; endocrine, nutritional and metabolic diseases; mental and be-havioral disorders; neurological diseases; diseases of the eye and adnexa; cardiovascular diseases; respiratory diseases; digestive diseases; diseases of the skin and subcutaneous tissue; diseases of the musculoskeletal system and connective tissue; or congenital malformations, de? formations and chromosomal abnormalities.

The reactant in an enzyme-catalyzed reaction is called a substrate. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction.I hope my blog about 138227-63-1 is helpful to your research. Related Products of 138227-63-1

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H22920N – PubChem

 

Synthetic Route of 138227-63-1, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 138227-63-1, Name is tert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylate, molecular formula is C16H24N2O3. In a Article£¬once mentioned of 138227-63-1

Design, synthesis and structure-activity relationships of benzoxazinone-based factor Xa inhibitors

A series of benzoxazinone derivatives was designed and synthesized as factor Xa inhibitors. We demonstrated that the naphthyl moiety in the aniline-based compounds 1 and 2 can be replaced with benzene-fused heterobicycles and biaryls to give factor Xa inhibitors with improved trypsin selectivity. The P4 modifications lead to monoamidines which are moderately active. The benzoxazinones 41-45 are potent against factor Xa, retain the improved trypsin selectivity of the corresponding aniline-based compounds, and show strong antithrombotic effect dose responsively.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Synthetic Route of 138227-63-1, you can also check out more blogs about138227-63-1

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H22945N – PubChem

 

Reference of 138227-63-1, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 138227-63-1, Name is tert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylate, molecular formula is C16H24N2O3. In a Article£¬once mentioned of 138227-63-1

The discovery of YM-60828: a potent, selective and orally-bioavailable factor Xa inhibitor.

Since Factor Xa (FXa) is well known to play a central role in thrombosis and hemostasis, inhibition of FXa is an attractive target for antithrombotic strategies. As a part of our investigation of a non-peptide, orally available FXa inhibitor, we found that a series of N-[(7-amidino-2-naphthyl)methyl]aniline derivatives possessed potent and selective inhibitory activities. Structure–activity relationship (SAR) of the substituent (R(1)) on the central aniline moiety suggested that increasing lipophilicity caused a detrimental effect on anticoagulant activity (prothrombin time assay) in plasma. Several compounds bearing a hydrophilic substituent in R(1) showed not only potent FXa inhibitory activities but also high anticoagulant activities. The best compound in this series was sulfamoylacetic acid derivative (YM-60828) which was a potent, selective and orally bioavailable FXa inhibitor and was chosen for clinical development.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.Reference of 138227-63-1, you can also check out more blogs about138227-63-1

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H22926N – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.138227-63-1,tert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

Reference Example 6 N-[4-(1-t-Butoxycarbonylpiperidin-4-yloxy)phenyl]ethanesulfonamide To a solution of 4-(1-t-butoxycarbonylpiperidin-4-yloxy)aniline (10.6 g) and pyridine (8 ml) in dichloromethane (75 ml) was added dropwise ethanesulfonyl chloride (4.1 ml) in an ice bath and the mixture was stirred at room temperature for 5 hours. After addition of methanol (1 ml), the reaction mixture was concentrated in vacuo. The residue was purified by chromatography on a silica gel column using hexane/ethyl acetate=3/2 as an eluant to give the desired compound (11.7 g, yield 84%) as a pale pink solid. 1H NMR (400 MHz, CDCl3) delta ppm: 1.38 (3H, t, J=8.0), 1.47 (9H, s), 1.74 (2H, m), 1.90 (2H, m), 3.07 (2H, q, J=8.0), 3.34 (2H, m), 3.69 (2H, m), 4.42 (1H, m), 6.88 (2H, d, J=9.0), 7.17 (2H, d, J=9.0)., 138227-63-1

138227-63-1 tert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylate 22181157, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Sankyo Company, Limited; US6555556; (2003); B1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem