Category: 138022-02-3

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Recommanded Product: 138022-02-3, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 138022-02-3, Name is tert-Butyl 4-((methylamino)methyl)piperidine-1-carboxylate, molecular formula is C12H24N2O2. In a Article, authors is Flanders, Yvonne，once mentioned of 138022-02-3

Herein, we describe the versatile synthesis of (Z)-5-((2-aminopyrimidin-4-yl)methylene)thiazolidine-2,4-dione inhibitors (1) of the PIM family of kinases. This chemistry strategy was a key element in the multi-variable optimization program with the goal of identifying high quality leads for the development of a treatment for cancer.

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about is helpful to your research. Recommanded Product: 138022-02-3

Reference：
Piperidine – Wikipedia,
Piperidine | C5H18385N – PubChem

 

Related Products of 138022-02-3, In heterogeneous catalysis, the catalyst is in a different phase from the reactants. At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 138022-02-3, name is tert-Butyl 4-((methylamino)methyl)piperidine-1-carboxylate. In an article，Which mentioned a new discovery about 138022-02-3

There is provided compounds of formula (I), wherein Ra, Rb, R2a, R2b, R2c, R2d, R2e and R3 have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. a PIM family kinase, such as PIM-1, PIM-2 and/or PIM-3, and/or Flt-3) is desired and/or required, and particularly in the treatment of cancer or a proliferative disease

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.138022-02-3. In my other articles, you can also check out more blogs about 138022-02-3

Reference：
Piperidine – Wikipedia,
Piperidine | C5H18370N – PubChem

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent£¬ Computed Properties of C12H24N2O2, Which mentioned a new discovery about 138022-02-3

Fused imidazopyridine derivatives as antihyperlipidemic agents

A novel compound of the formula: wherein ring Q is an optionally substituted pyridine ring;One of R0, R1 and R2 is ?Y0?Z0, and the other tow groups are a hydrogen, a halogen, an optionally substituted hydroxy group, a hydrocarbon group that may be an optionally substituted hydrocarbon group or an acyl group;Y0 is a bond or an optionally substituted bivalent hydrocarbon group;Z0 is a basic group which may be bonded via oxygen, nitrogen, ?CO?, ?CS?, ?SO2N(R3)? (where R3 is hydrogen or an optionally substituted hydrocarbon group), or S(O)n (wherein n is to 0, 1 or 2);………is a single bond or a double bond, or a salt thereof, which has an excellent LDL receptor up-regulating, blood-lipids lowering, blood-sugar lowering and diabetic complication-ameliorating activity.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 138022-02-3, help many people in the next few years.Computed Properties of C12H24N2O2

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H18387N – PubChem

 

138022-02-3, tert-Butyl 4-((methylamino)methyl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-{[(4-Cyano-benzoyl)-methyl-amino]-methyl}-piperidine-1-carboxylic acid tert-butyl ester To a stirred solution of 4-cyanobenzoic acid (322 mg, 2.19 mmol) in CH2Cl2 (10 mL) was added TBTU (702 mg, 2.19 mmol) and N,N-diisopropylethylamine (1.14 mL, 6.54 mmol) and the reaction mixture stirred at RT for 10 min. 4-Methylaminomethyl-piperidine-1-carboxylic acid tert-butyl ester (500 mg, 2.19 mmol) in DMF (4 mL) was added and the reaction mixture was stirred at RT for 2 h. The crude material was concentrated in vacuo and purified by silica gel column chromatography, eluting with isohexane and increasing the polarity to 100percent EtOAc to afford 4-{[(4-cyano-benzoyl)-methyl-amino]-methyl}-piperidine-1-carboxylic acid tert-butyl ester as a orange solid (700 mg, 89percent). AnalpH2_MeOH-4 min(1): Rt 2.73 min; m/z 358 [M+1]+.

138022-02-3, The synthetic route of 138022-02-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Ashworth, Alan; Lord, Christopher James; Elliot, Richard James Rowland; Niculescu-Duvaz, Dan; Porter, Roderick; Boffey, Raymond John; Bayford, Melanie Jayne; Firth-Clark, Stuart; Jarvis, Ashley Nicholas; Perrior, Trevor Robert; Key, Rebekah Elisabeth; US2015/99732; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

138022-02-3, tert-Butyl 4-((methylamino)methyl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(E)-3-(4-Chloro-2-((5-methyl-2 H-tetrazol-2-yl) methyl)phenyl)acrylic acid (Intermediate A)(200 mg, 0.718 mmol) and tert-butyl 4-((methylamino)methyl)piperidine-1-carboxylate (154mg, 0.718 mmol) were dissolved in DMF (3 ml). DIPEA (501 ul, 2.87 mmol) was added followed by 50percent T3P? solution in DMF (838 ul, 1.435 mmol) and the mixture was stirred at room temperature overnight. The resulting mixture was concentrated in vacuo. The residue was dissolved in EtOAc and washed with 10percent citric acid, saturated bicarbonate solution,brine, dried over MgSO4, filtered and concentrated in vacuo. Purification by chromatography on silica eluting with a gradient of EtOAc in iso-hexane afforded the title compound; LCMS: Rt 1.26 mins MS mlz 389.5 [M+H-Boc]+ Method 2minLowpHvol., 138022-02-3

138022-02-3 tert-Butyl 4-((methylamino)methyl)piperidine-1-carboxylate 21934652, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; NOVARTIS AG; BAETTIG, Urs; BEATTIE, David; LEGRAND, Darren Mark; LISTER, Andrew Stuart; MCKENNA, Jeffrey; PEARCE, David William; SANDHAM, David Andrew; STANLEY, Emily; STEWARD, Oliver Ross; THOMSON, Christopher; WO2015/8229; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem