Category: 1312412-87-5

1312412-87-5, tert-Butyl 3-bromo-2,4-dioxopiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[0148] Method H-Step d: Tert-butyl 2-amino-4-oxo-6,7-dihydrothiazolo[5,4-c]pyridine- 5(4H)-carboxylate [0149] A mixture of tert-butyl 3-bromo-2,4-dioxopiperidine-l-carboxylate (292 mg, 1 mmol), thiourea (76 mg, 1 mmol) and NaHCC>3 (84 mg, 1 mmol) in ethanol (4 mL) was heated at 80C for 2 hours. The reaction mixture was then cooled to room temperature and the solids were filtered off. The filtrate was evaporated in vacuo to give a residue that was crystallized from EtOH. The white crystals thus obtained were filtered off and dried to yield 200 mg (74.3% for two steps). *H NMR (400 MHz, DMSO-i5) delta 8.08 (s, 2H), 3.89 (t, J Hz, 2H), 2.75 (t, / = 6.4 Hz, 2H), 1.44 (s, 9H)., 1312412-87-5

1312412-87-5 tert-Butyl 3-bromo-2,4-dioxopiperidine-1-carboxylate 69919790, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; ZHANG, Xiaohu; WO2014/113191; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

1312412-87-5, tert-Butyl 3-bromo-2,4-dioxopiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step iv: tert-butyl 2-amino-4-oxo-6,7-dihvdrothiazolo[5,4-clpyridine-5(4H)-carboxylate To a 50 mL round bottom flask, were added tert-butyl 3-bromo-2,4-dioxopiperidine-l- carboxylate (1 g, 0.0034 mol), thiourea (0.287 g, 0.0038 mol), sodium bicarbonate (0.317 g, 0.0038 mol) and ethanol (15 mL). The reaction mixture was stirred at 80 C for 2.5 h. The volatiles were evaporated under reduced pressure to get residue. The residue was partitioned between ethyl acetate and water. The organic layer was separated, washed with brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to obtain the title compound [0.7 g, 76 %]. NMR (300 MHz, CDsOD): delta 4.05 (t, 2H), 2.83 (t, 2H), 1.52 (s, 9H)., 1312412-87-5

The synthetic route of 1312412-87-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AURIGENE DISCOVERY TECHNOLOGIES LIMITED; KOTRABASAIAH UJJINAMATADA, Ravi; HOSAHALLI, Subramanya; BEJUGAM, Mallesham; WO2015/101928; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem