Category: 13096-31-6

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13096-31-6,5-Hydroxypiperidine-2-carboxylic acid,as a common compound, the synthetic route is as follows.,13096-31-6

To a mixture of 413 5-hydroxypiperidine-2-carboxylic acid (62 g, 427.13 mmol, 1 eq.) and Boc2O (102.54 g, 469.84 mmol, 107.94 mL, 1.1 eq.) in 46 dioxane (500 mL) was added 358 NaOH (34.17 g, 854.25 mmol, 2 eq.) and the mixture was stirred at 25 C. for 18 hrs. The mixture was then concentrated to remove dioxane and the pH was adjusted to 2-3 by addition of 1N HCl solution. The aqueous phase was extracted with 2-Me-THF (500 mL*3). The combined organic layers was dried over Na2SO4, filtered and concentrated to give 415 1-tert-butoxycarbonyl-5-hydroxy-piperidine-2-carboxylic acid (40 g, crude) as yellow oil. ESI [M+Na]=267.9

As the paragraph descriping shows that 13096-31-6 is playing an increasingly important role.

Reference：
Patent; Cyteir Therapeutics, Inc.; Castro, Alfredo C.; McComas, Casey Cameron; Vacca, Joseph; Maclay, Tyler; (132 pag.)US2019/77799; (2019); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

13096-31-6, 5-Hydroxypiperidine-2-carboxylic acid is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The upper step of the product (365.22g, 2 . 516 muM, 1 . 0eq.) dissolved in MeOH (3000 ml) in. under the ice-bath adds by dropsSOCl2(448.99g, 3.774mol, 1.5eq.)dropping process temperature can be raised to reflux, then completing, reflux 2h. LC – Ms detection reaction is complete; reducing pressure and solvent, a brown yellow liquid 489.81g, yield (theoretical): 100%. The crude product directly into the next step., 13096-31-6

13096-31-6 5-Hydroxypiperidine-2-carboxylic acid 151730, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; Nanjing Furun Cade Biological Medicine Co., Ltd; Shi, Xiang; Liu, Guihua; Lian, Huawen; (18 pag.)CN106045999; (2016); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

13096-31-6, 5-Hydroxypiperidine-2-carboxylic acid is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 23 1-(3-Mercaptopropanoyl)-5-Hydroxy-L-Pipecolic Acid By substituting 5-hydroxy-L-pipecolic acid for L-proline in procedure of Example 13 and then treating the product by the Procedure A of Example 18, 1-(3-benzoylthiopropanoyl)-5-hydroxy-L-pipecolic, and 1-(3-mercaptopropanoyl)-5-hydroxy-L-pipecolic acid are obtained.

13096-31-6, As the paragraph descriping shows that 13096-31-6 is playing an increasingly important role.

Reference：
Patent; E. R. Squibb & Sons, Inc.; US4046889; (1977); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13096-31-6,5-Hydroxypiperidine-2-carboxylic acid,as a common compound, the synthetic route is as follows.

EXAMPLE 23 1-(3-Mercaptopropanoyl)-5-Hydroxy-L-Pipecolic Acid By substituting 5-hydroxy-L-pipecolic acid for L-proline in the procedure of Example 13 and then treating the product by the Procedure A of Example 18, 1-(3-benzoylthiopropanoyl)-5-hydroxy-L-pipecolic, and 1-(3-mercaptopropanoyl)-5-hydroxy-L-pipecolic acid are obtained.

13096-31-6, The synthetic route of 13096-31-6 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; E. R. Squibb & Sons, Inc.; US4105776; (1978); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem