Category: 1258323-45-3

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Potassium trifluoro(1-methyl-1H-pyrazol-5-yl)borate, is researched, Molecular C4H5BF3KN2, CAS is 1258323-45-3, about Nickel-Catalyzed Cross-Coupling of Potassium Aryl- and Heteroaryltrifluoroborates with Unactivated Alkyl Halides, the main research direction is arene preparation; potassium aryltrifluoroborate alkyl halide cross coupling nickel catalyst.Quality Control of Potassium trifluoro(1-methyl-1H-pyrazol-5-yl)borate.

A method for the cross-coupling of alkyl electrophiles with various potassium aryl- and heteroaryltrifluoroborates has been developed. Nearly stoichiometric amounts of organoboron species could be employed to cross-couple a large variety of challenging heteroaryl nucleophiles. Several functional groups were tolerated on both the electrophilic and the nucleophilic partners. Chemoselective reactivity of C(sp3)-Br bonds in the presence of C(sp2)-Br bonds was achieved.

In addition to the literature in the link below, there is a lot of literature about this compound(Potassium trifluoro(1-methyl-1H-pyrazol-5-yl)borate)Quality Control of Potassium trifluoro(1-methyl-1H-pyrazol-5-yl)borate, illustrating the importance and wide applicability of this compound(1258323-45-3).

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Potassium trifluoro(1-methyl-1H-pyrazol-5-yl)borate, is researched, Molecular C4H5BF3KN2, CAS is 1258323-45-3, about Furo[3,2-b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway, the main research direction is synthesis furopyridine; furopyridine cdc like kinase inhibitor Hedgehog pathway modulator; biological activity; chemical probes; heterocycles; inhibitors; kinases.Category: piperidines.

Reported is the identification of the furo[3,2-b]pyridine core as a novel scaffold for potent and highly selective inhibitors of cdc-like kinases (CLKs) and efficient modulators of the Hedgehog signaling pathway. Initially, a diverse target compound set was prepared by synthetic sequences based on chemoselective metal-mediated couplings, including assembly of the furo[3,2-b]pyridine scaffold by copper-mediated oxidative cyclization. Optimization of the subseries containing 3,5-disubstituted furo[3,2-b]pyridines, e.g. I, afforded potent, cell-active, and highly selective inhibitors of CLKs. Profiling of the kinase-inactive subset of 3,5,7-trisubstituted furo[3,2-b]pyridines, e.g. II, revealed sub-micromolar modulators of the Hedgehog pathway.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem