Category: 125224-43-3

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.125224-43-3,((3S,4R)-4-(4-Fluorophenyl)piperidin-3-yl)methanol,as a common compound, the synthetic route is as follows.

Preparation of compound 13b was accomplished by dissolving ((3S,4R)-4-(4-fluorophenyl)piperidin-3- yl)methanol (0.765 mmol, 0.160 g) and sodium cyanoborohydride (2.30 mmol, 0.144 g) in THF (2.0 mL) and acetone (2.0 mL) at 0C. Acetic acid (3.06 mmol, 0.175 mL) was then added dropwise and the reaction was stirred overnight warming to room temperature. The reaction was neutralized with 2N NaOH and then extracted with ethyl acetate. The organic layer was washed 2x with NaCl, dried over MgSO4 and concentrated to give the desired product (0.15 g, 78% yield).

125224-43-3, As the paragraph descriping shows that 125224-43-3 is playing an increasingly important role.

Reference：
Article; Bouley, Renee; Waldschmidt, Helen V.; Cato, M. Claire; Cannavo, Alessandro; Song, Jianliang; Cheung, Joseph Y.; Yao, Xin-Qiu; Koch, Walter J.; Larsen, Scott D.; Tesmer, John J.G.; Molecular Pharmacology; vol. 92; 6; (2017); p. 707 – 717;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

125224-43-3, ((3S,4R)-4-(4-Fluorophenyl)piperidin-3-yl)methanol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of ((3S, 4R)-4-(4-fluorophenyl)piperidin-3-yl)methanol (1.00 g, 4.8 mmol) in methylene chloride (20 mL), was added triethylamine (1.30 mL, 9.3 mmol) and di-tert-butyl dicarbonate (1.50 g, 6.9 mmol). The resulting reaction mixture was stirred at ambient temperature for 20 h and concentrated in vacuo. The residue was dissolved in ethyl acetate (200 mL) and washed with saturated sodium bicarbonate solution (50 mL) and brine (50 mL); dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated in vacuo, and the residue was purified by column chromatography (30% ethyl acetate in hexanes) to afford (3S,4/?)-te/f-butyl 4- (4-fluorophenyl)-3-(hydroxymethyl)piperidine-1-carboxylate in 92% yield (1.36 g) as a colorless solid: 1H NMR (300 MHz, CDCI3) 7.22 (d, J = 8.4 Hz, 2H), 7.08 (d, J = 8.4 Hz, 2H), 4.50-4.15 (m, 2H), 3.43 (s, 3H), 2.95-2.58 (m, 4H), 1.80-1.49 (m, 2H), 1.49 (s, 9H)., 125224-43-3

The synthetic route of 125224-43-3 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; XENON PHARMACEUTICALS INC.; SUN, Shaoyi; ZENOVA, Alla, Yurevna; CHAFEEV, Mikhail; JIA, Qi; ZHANG, Zaihui; OBALLA, Renata, Marcella; WO2013/64983; (2013); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

125224-43-3, ((3S,4R)-4-(4-Fluorophenyl)piperidin-3-yl)methanol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation of compound 13a was accomplished by dissolving ((3S,4R)-4-(4-fluorophenyl)piperidin-3-yl)methanol 12 (1.49 mmol, 0.311 g) in DMF (6.0 mL). Potassium carbonate (3.73 mmol, 0.515g) and ethyl iodide (1.63 mmol, 0.13 mL) were then added and the reaction was stirred overnight at room temperature. The reaction was then concentrated in vacuo and the crude residue was purified using flash chromatography 4 – 10 % MeOH (3M ammonia)/DCM to give ((3S,4R)-1-ethyl-4- (4-fluorophenyl)piperidin-3-yl)methanol (0.167g, 47% yield)., 125224-43-3

125224-43-3 ((3S,4R)-4-(4-Fluorophenyl)piperidin-3-yl)methanol 9855829, apiperidines compound, is more and more widely used in various fields.

Reference：
Article; Bouley, Renee; Waldschmidt, Helen V.; Cato, M. Claire; Cannavo, Alessandro; Song, Jianliang; Cheung, Joseph Y.; Yao, Xin-Qiu; Koch, Walter J.; Larsen, Scott D.; Tesmer, John J.G.; Molecular Pharmacology; vol. 92; 6; (2017); p. 707 – 717;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.125224-43-3,((3S,4R)-4-(4-Fluorophenyl)piperidin-3-yl)methanol,as a common compound, the synthetic route is as follows.

To a mixture of [(3S,4R)-4-(4-fluorophenyl)piperidine-3-yl]methanol (3.0 g, 14 mmol), sodium carbonate (6.1 g, 57 mmol), dichloromethane (40 mL) and water (40 mL) was added di-tert-butyl Bicarbonate (3.8 g, 17 mmol) under ice cooling, followed by stirring at the same temperature for 30 minutes. The reaction mixture was added to a mixed solution of dichloromethane and water, and the organic layer was separated. The organic layer was washed with brine and dried over anhydrous magnesium sulfate, and the solvent was distilled away under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate_heptane=1:1) to give the title compound (4.0 g, 90% yield). 1H-NMR Spectrum (CDCl3) delta (ppm): 1.49 (9H, s), 1.61-1.71 (1H, m), 1.75-1.85 (2H, m), 2.51-2.56 (1H, m), 2.71 (1H, dd, J=11.3, 13.2 Hz), 2.78 (1H, br s), 3.24-3.29 (1H, m), 3.42-3.46 (1H, m), 4.20 (1H, br s), 4.36 (1H, d, J=11.7 Hz), 6.97-7.03 (2H, m), 7.13-7.18 (2H, m).

125224-43-3, 125224-43-3 ((3S,4R)-4-(4-Fluorophenyl)piperidin-3-yl)methanol 9855829, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; EISAI R&D MANAGEMENT CO., LTD.; Tanaka, Keigo; Nishioka, Tomoki; US2013/197033; (2013); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

125224-43-3, ((3S,4R)-4-(4-Fluorophenyl)piperidin-3-yl)methanol is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[(3S,4R)-4-(4-Fluoro-phenyl)-piperidin-3-yl]-methanol (3.00 g, 14.3 mmol, 1 equiv) was suspended in CH2Cl2 (10 mL) and Boc anhydride (3.23 g, 14.8 mmol, 1.03 equiv) was added. This was stirred for 2 h then concentrated to give the crude, which was used in the next reaction without further purification. [

125224-43-3, As the paragraph descriping shows that 125224-43-3 is playing an increasingly important role.

Reference：
Patent; CHEMOCENTRYX, INC.; FAN, Junfa; KALISIAK, Jaroslaw; LUI, Rebecca, M.; MALI, Venkat, Reddy; MCMAHON, Jeffrey, P.; POWERS, Jay, P.; TANAKA, Hiroko; ZENG, Yibin; ZHANG, Penglie; (194 pag.)WO2016/187393; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem