Category: 1245648-32-1

1245648-32-1, tert-Butyl 4-oxo-2-(trifluoromethyl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Sodium borohydride (71 mg, 1.87 mmol) was added at -10 °C to a solution of 1-boc-2-trifluoromethyl-piperidin-4-one (250 mg, 0.94 mmol) in MeOH (8 mL) and the reaction stirred at -10 °C for lh. Sat. aq. NH4CI (3 mL) was added, and the resulting mixture allowed to warm to RT. The MeOH was removed under reduced pressure, and the resulting aqueous layer extracted with DCM (4 x 5 mL). Thecombined organics were washed with brine, dried over Mg504, filtered and concentrated under reduced pressure to afford 247.6 mg (98percent yield) of the title compound as colourless oil.1H NMR (250 MHz, Chloroform-d): 6 [ppm] 4.84 – 4.62 (m, 1H), 4.15 – 3.95 (m, 2H),3.39- 3.18 (m, 1H), 2.10-2.00 (m, 1H), 1.91 – 1.57 (m, 3H), 1.47 (5, 9H)., 1245648-32-1

As the paragraph descriping shows that 1245648-32-1 is playing an increasingly important role.

Reference：
Patent; EVOTEC AG; DAVENPORT, Adam James; BRAEUER, Nico; FISCHER, Oliver Martin; ROTGERI, Andrea; ROTTMANN, Antje; NEAGOE, Ioana; NAGEL, Jens; GODINHO-COELHO, Anne-Marie; (703 pag.)WO2016/91776; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1245648-32-1,tert-Butyl 4-oxo-2-(trifluoromethyl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of 2-(benzo[djthiazol-2-yl)acetonitrile (300 mg, 1.72 mmol) in ethanol (10 mL) was added tert-butyl 4-oxo-2-(trifluoromethyl)piperidine-1-carboxylate (460 mg, 1.72 mmol), elemental sulfur (55 mg, 1.72 mmol) and morpholine (150 mg, 1.72 mmol) at room temperature and the resulting reaction mixture was heated to reflux at 85 °C for 4 h and monitored by TLC. The reaction mixture was dried under vacuum pressure and the crude compound was purified by trituration with methanol to afford the mixture of the title compounds as an off white solid (700 mg, yield 89percent). LCMS: [M+Hj = 456.0; R = 3.50 mm, [M+Hj = 455.9; R = 3.59 mm., 1245648-32-1

The synthetic route of 1245648-32-1 has been constantly updated, and we look forward to future research findings.

Reference：
Patent; SYROS PHARMACEUTICALS, INC.; ROBERTS, Christopher; ZHANG, Yi; BEAUMIER, Francis; LEPISSIER, Luce; MARINEAU, Jason, J.; RAHL, Peter, B.; SPROTT, Kevin; CIBLAT, Stephane; SOW, Boubacar; LAROUCHE-GAUTHIER, Robin; BERSTLER, Lauren; (469 pag.)WO2016/197078; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1245648-32-1,tert-Butyl 4-oxo-2-(trifluoromethyl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

NaBH4 (76 mg; 2 mmol; 2 eq.) was added at -10°C to a solution of 1-Boc-2- trifluoromethyl- piperidin-4-one (Small Molecules inc.) (267 mg; 1 mmol; 1 eq.) in MeOH (8 mL) and the reaction mixture was stirred at -10°C for 1 hour. Sat. aq. NH4CI (3 mL) was added and the resulting mixture was allowed to return to room temperature. The MeOH was evaporated in vacuo and the resulting aqueous layer extracted with DCM (4x). The combined organics were washed with brine, dried over magnesium sulfate and concentrated in vacuo to afford the title compound (269 mg, 100percent) as a colourless oil. 1H NMR (CDCI3) delta 4.74 (br s, 1 H), 4.19-3.93 (m, 2H), 3.42-3.17 (m, 1H), 2.14-1.90 (m, 2H), 1.90-1.52 (m, 3H), 1.52-1.37 (m, 9H)., 1245648-32-1

1245648-32-1 tert-Butyl 4-oxo-2-(trifluoromethyl)piperidine-1-carboxylate 71607278, apiperidines compound, is more and more widely used in various fields.

Reference：
Patent; MERCK PATENT GMBH; SWINNEN, Dominique; MONTAGNE, Cyril; POMEL, Vincent; QUATTROPANI, Anna; MOLETTE, Jerome; GERBER, Patrick; WO2013/91773; (2013); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem