Category: 1209780-71-1

New learning discoveries about 1209780-71-1

1209780-71-1 tert-Butyl 3,3-difluoro-4-hydroxypiperidine-1-carboxylate 56932106, apiperidines compound, is more and more widely used in various fields.

1209780-71-1, tert-Butyl 3,3-difluoro-4-hydroxypiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Tert-butyl 3,3-difluoro-4-hydroxypiperidine-1-carboxylate (8-1) (100 mg, 0.42 mmol) and tetrahydrofuran (5 mL) were added to a 25 mL flask, and cooled to 0 C under protection of nitrogen, sodium hydride (20 mg, 0.5 mmol) was added thereto, and the reaction was performed for 30 minutes. Iodomethane (120 mg, 0.84 mmol) was then added thereto, and the reaction was performed for 16 hours. The reaction solution was slowly poured into water, and a crude product of the title compound 100 mg was obtained after work-up, and was used directly for the next reaction without purification. ESI-MS (m/z): 252.2 [M+H]+,, 1209780-71-1

1209780-71-1 tert-Butyl 3,3-difluoro-4-hydroxypiperidine-1-carboxylate 56932106, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd.; SONG, Shuai; CAI, Jiaqiang; TIAN, Qiang; ZENG, Hong; SONG, Hongmei; DENG, Hanwen; TANG, Zujian; DUAN, Xiaofan; LONG, Rongrong; LIU, Yao; WANG, Lichun; WANG, Jingyi; (80 pag.)EP3508483; (2019); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

Some tips on 1209780-71-1

1209780-71-1, The synthetic route of 1209780-71-1 has been constantly updated, and we look forward to future research findings.

1209780-71-1, tert-Butyl 3,3-difluoro-4-hydroxypiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

tert-Butyl 3,3-difluoro-4- hydroxypiperidine-1-carboxylate (0.0706 g, 0.298 mmol) was treated with 1 M KOtBu in THF (0.283 mL, 0.283 mmol) and stirred for 15 minutes. The solution was treated with 2- ([l,2,4]triazolo[4,3-a]pyridin-3-yl)-6,8-difluoroquinoline (0.042 g, 0.149 mmol) and DMF (0.80 mL) then the mixture was stirred at ambient temperature for 16 hours. The mixture was directly chromatographed on SiO2 eluting with a gradient of 2% NH4OH in isopropanol/ethyl acetate. The desired product was collected and concentrated to a colorless oil, (72 mg). MS APCI (+) m/z 500.0 (M+l) detected.

1209780-71-1, The synthetic route of 1209780-71-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ARRAY BIOPHARMA INC.; ALLEN, Shelley; CELESTE, Laura L.; DAVIS, T. Gregg; DELISLE, Robert Kirk; GRESCHUK, Julie Marie; GROSS, Stefan, D.; HICKEN, Erik, James; JACKSON, Leila, J.; LYSSIKATOS, Joseph, P.; KALLAN, Nicholas C.; MARMSATER, Fredrik, P.; MUNSON, Mark, C.; PHENEGER, Jed; RAST, Bryson; ROBINSON, John, E.; SCHLACHTER, Stephen T.; TOPALOV, George T.; WRIGHT, A. Dale; ZHAO, Qian; WO2010/22076; (2010); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

Some tips on 1209780-71-1

The synthetic route of 1209780-71-1 has been constantly updated, and we look forward to future research findings.

1209780-71-1, tert-Butyl 3,3-difluoro-4-hydroxypiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[To asuspension of NaH (60%, 3.44g, 86.1 mmol) in THF (250 mL) was added tert-butyl 3, 3-difluoro-4-hydroxypiperidine-1-carboxylate (16.8 g, 70.7 mmol) at 0 under N 2. The mixture was stirred at 0 for 30 min. Then to the mixture was added 5-fluoro-7-methoxy-3- ( (2- (trimethylsilyl) ethoxy) methyl) quinazolin-4 (3H) -one (20.0 g, 61.5 mmol) at 0 . The reaction mixture was stirred for 4 h. LCMS showed the reaction was complete. The reaction mixture was quenched with ice water and extracted with EtOAc (200 mL x2) . The combined organic layer was dried over anhydrous Na 2SO 4, filtered and concentrated to give a residue. The residue was purified by silica gel chromatography (PE/EtOAc = 2/1) to give the product (30.0 g, 90%yield) as a white solid. MS (ESI) m/z: 542.3 (M+H) +.

The synthetic route of 1209780-71-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SUZHOU ZANRONG PHARMA LIMITED; ZHOU, Ding; CHENG, Ziqiang; (0 pag.)WO2020/57511; (2020); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem