Category: 120014-07-5

In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 120014-07-5, name is 2-((1-Benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one, introducing its new discovery. Quality Control of: 2-((1-Benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one

The invention discloses a method for the preparation of donepezil hydrochloride, the 3-chloro-1 – (3,4-dimethoxyphenyl) propan-1-one (II) and N-benzyl-4-piperidyl base formaldehyde (III) the Lewis acid ionic liquid catalyst reaction under the conditions of, one-pot synthesis to make 1-benzyl-4 – (5,6 dimethoxy-1-indan-2-methylene)-piperidine (IV), and then passes through the reduction, to a (I) donepezil hydrochloride salt. The invention has the advantages of simple process, low production cost, environment-friendly, is suitable for industrial production. (by machine translation)

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 120014-07-5 is helpful to your research. Quality Control of: 2-((1-Benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one

Reference：
Piperidine – Wikipedia,
Piperidine | C5H23886N – PubChem

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， name: 2-((1-Benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one, Which mentioned a new discovery about 120014-07-5

The present invention relates to new indanone inhibitors of acetylcholinesterase, pharmaceutical compositions thereof, and methods of use thereof.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 120014-07-5, help many people in the next few years.name: 2-((1-Benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one

Reference：
Piperidine – Wikipedia,
Piperidine | C5H23879N – PubChem

 

Electric Literature of 120014-07-5, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.120014-07-5, Name is 2-((1-Benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one, molecular formula is C24H27NO3. In a Article，once mentioned of 120014-07-5

A simple, efficient and highly economic process for the production of donepezil hydrochloride (1), an anti-Alzheimer drug is reported. The process relies upon improved and large-scale synthesis of a key intermediate: 1-benzylpiperidine-4-carboxaldehyde (2), and the introduction of operationally simple chemistry at the penultimate stage wherein 2 is reacted with 5,6-dimethoxy indanone (3) in the presence of sodium hydroxide and a phase transfer catalyst (PTC) in a biphasic solvent to furnish the intermediate 4, which is reduced and directly treated with hydrochloric acid to furnish highly pure donepezil hydrochloride with desired polymorphic form. The improved process provides donepezil hydrochloride at considerably lower cost and allows the omission of hazardous chemicals.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Electric Literature of 120014-07-5, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 120014-07-5

Reference：
Piperidine – Wikipedia,
Piperidine | C5H23894N – PubChem

 

Electric Literature of 120014-07-5, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.120014-07-5, Name is 2-((1-Benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one, molecular formula is C24H27NO3. In a article£¬once mentioned of 120014-07-5

Processes for Preparing Donepezil

A process for preparing highly pure donepezil, particularly donepezil hydrochloride, is provided comprising hydrogenating compound 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-ylidene]methyl-piperidine or its hydrochloride salt with a noble metal catalyst or a derivative thereof, in the presence of at least one additive, wherein the additive contains at least one heteroatom, e.g., a sulfur, phosphorous, or nitrogen heteroatom.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 120014-07-5, and how the biochemistry of the body works.Electric Literature of 120014-07-5

Reference£º
Piperidine – Wikipedia,
Piperidine | C5H23895N – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.120014-07-5,2-((1-Benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one,as a common compound, the synthetic route is as follows.

Preparation of l-Benzyl-4-[(5, 6-dimethoxy-l-indanon)-2-v? methylpiperidine hydrochloride (Donepezil Hydrochloride) l-Benzyl-4-[5, 6-dimethoxy-l-indanon)-2-ylidenyl] methyl piperidine was taken in tetrahydrofuran (200ml) followed by addition of palladium-carbon (Ig). The mixture was hydrogenated at 20-30 0C under 1,5 atmospheric pressure for 8 hours, monitored by HPLC analysis and analysis shows ~ 38.5% of debenzylated impurity in the reaction mass.

120014-07-5, 120014-07-5 2-((1-Benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one 10762160, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; IND-SWIFT LABORATORIES LIMITED; WO2007/108011; (2007); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.120014-07-5,2-((1-Benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one,as a common compound, the synthetic route is as follows.

To 200 mL of toluene were added 20 g of 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-ylidene]methyl-piperidine and 2 g of 10% palladium-carbon. Hydrogenation was carried out with stirring for 5 hours at 0 to 1 C. and 0.8 to 1.0 MPa. HPLC Purity of the Reaction Solution: the desired compound/72.9%, the starting material/25.3%, the debenzylated product/1.8%.

120014-07-5, As the paragraph descriping shows that 120014-07-5 is playing an increasingly important role.

Reference£º
Patent; Eisai R&D Management Co., Ltd.; US2007/88055; (2007); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem